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Medicine

D-Index
76
Citations
18147
World Ranking
18900
National Ranking
9418

Overview

Lawrence J. Lesko is affiliated with the University of Florida in the United States and focuses primarily on medical research. Their scholarly work spans several interrelated fields including cardiology and cardiovascular medicine, pharmacology, economics and econometrics, pediatrics, perinatology and child health, as well as immunology. The research output in these areas totals over 33 publications, indicating a broad yet specialized engagement with key aspects of medicine.

The main topics that characterize Lesko's research activities include pharmacogenetics and drug metabolism, pharmaceutical studies and practices, statistical methods in clinical trials, biosimilars and bioanalytical methods, health systems, economic evaluations, and quality of life, computational drug discovery methods, and atrial fibrillation management and outcomes.

Lesko has contributed to a number of research papers published in well-recognized scientific venues. Notable publications include:

  • Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy, 2020, The Annual Review of Pharmacology and Toxicology
  • Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine, 2020, Drug Discovery Today
  • Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function, 2020, JAMA Network Open
  • Perspective on model-informed drug development, 2021, CPT Pharmacometrics & Systems Pharmacology
  • A Review on Drug-Induced Nephrotoxicity: Pathophysiological Mechanisms, Drug Classes, Clinical Management, and Recent Advances in Mathematical Modeling and Simulation Approaches, 2020, Clinical Pharmacology in Drug Development

Frequent publication venues for Lesko include CPT Pharmacometrics & Systems Pharmacology, The Journal of Clinical Pharmacology, Clinical Pharmacology & Therapeutics, Clinical and Translational Science, and The Annual Review of Pharmacology and Toxicology.

Lesko maintains collaborative relationships with several recurring coauthors, including Mirjam N. Trame, Sarah Kim, Hardik Mody, Theodoros Soldatos, and Stephan Schmidt. These ongoing collaborations are reflected in multiple joint publications and research initiatives.

Best Publications

  • Biopharmaceutics Classification System: The Scientific Basis for Biowaiver Extensions

    Lawrence X. Yu;Gordon L. Amidon;James E. Polli;Hong Zhao

  • Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies.

    LJ Lesko;AJ Atkinson

  • Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review.

    P. Zhao;L. Zhang;J. A. Grillo;Q. Liu

  • Drug interaction studies: study design, data analysis, and implications for dosing and labeling.

    Huang Sm;Temple R;Throckmorton Dc;Lesko Lj

  • The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

    Zaiqi Wang;Zaiqi Wang;J. Christopher Gorski;J. Christopher Gorski;Mitchell A. Hamman;Mitchell A. Hamman;Shiew‐Mei Huang;Shiew‐Mei Huang

  • New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process

    Shiew Mei Huang;John M. Strong;Lei Zhang;Kellie S. Reynolds

  • Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models.

    Zhang Xy;Trame Mn;Lesko Lj;Schmidt S

  • Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues.

    Brian F. Gage;Lawrence J. Lesko

  • Pharmacogenomic Biomarker Information in Drug Labels Approved by the United States Food and Drug Administration: Prevalence of Related Drug Use

    Felix W. Frueh;Shashi Amur;Padmaja Mummaneni;Robert S. Epstein

  • Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias.

    C I Haffajee;J C Love;A T Canada;L J Lesko

  • Medical applications of microarray technologies: a regulatory science perspective

    Emanuel F. Petricoin;Joseph L. Hackett;Lawrence J. Lesko;Raj K. Puri

  • Effect of St John's wort on the pharmacokinetics of fexofenadine.

    Zaiqi Wang;Mitchell A. Hamman;Shiew‐Mei Huang;Lawrence J. Lesko

  • Bioavailability and Bioequivalence: An FDA Regulatory Overview

    Mei-Ling Chen;Vinod Shah;Rabindra Patnaik;Wallace Adams

  • Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective.

    Lawrence J. Lesko;Janet Woodcock

  • Pharmacokinetic/pharmacodynamic modeling in drug research and development.

    Hartmut Derendorf;Lawrence J. Lesko;Philip Chaikin;Wayne A. Colburn

  • Personalized medicine: elusive dream or imminent reality?

    L J Lesko

  • Bioequivalence of Topical Dermatological Dosage Forms-Methods of Evaluation of Bioequivalence

    Vinod P. Shah;Gordon L. Flynn;Avraham Yacobi;Howard I. Maibach

  • Why has model-informed precision dosing not yet become common clinical reality?: Lessons from the past and a roadmap for the future

    A S Darwich;K Ogungbenro;A A Vinks;J R Powell

  • Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans.

    Lawrence J Lesko;Malcolm Rowland;Carl C Peck;Terrence F Blaschke

  • Medical applications of microarray technologies: a regulatory science perspective: a regulatory science perspective

    E. F. Petricoin;L. J. Lesko;J. L. Hackett

Frequent Co-Authors

Gordon L. Amidon
Gordon L. Amidon University of Michigan–Ann Arbor
Amin Rostami-Hodjegan
Amin Rostami-Hodjegan University of Manchester
Malcolm Rowland
Malcolm Rowland University of Manchester
Gordon L. Flynn
Gordon L. Flynn University of Michigan–Ann Arbor
Hans Lennernäs
Hans Lennernäs Uppsala University
Howard I. Maibach
Howard I. Maibach University of California, San Francisco
Mark J. Ratain
Mark J. Ratain University of Chicago
Alan R. Shuldiner
Alan R. Shuldiner University of Maryland, Baltimore
Weida Tong
Weida Tong National Center for Toxicological Research
Mary V. Relling
Mary V. Relling St. Jude Children's Research Hospital

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