World's Best Scientists 2026 revealed!
Isabelle M. Mansuy

Isabelle M. Mansuy

D-Index & Metrics

Neuroscience

D-Index
68
Citations
20055
World Ranking
2726
National Ranking
66

Biology and Biochemistry

D-Index
68
Citations
18209
World Ranking
7731
National Ranking
142

Research.com Recognitions

  • 2017 - Member of the European Academy of Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Isabelle M. Mansuy is affiliated with the University of Zurich in Switzerland and has a significant body of research focusing on biochemistry, genetics, and molecular biology, with considerable work intersecting the fields of medicine.

Their research primarily covers molecular biology and its subfields, including pediatrics, perinatology, child health, and behavioral neuroscience. The scientist's work also extends to genetics, health toxicology, and mutagenesis, contributing to an understanding of biological mechanisms affecting health and development.

Main topics explored by Mansuy include birth, development, and health; epigenetics and DNA methylation; stress responses and cortisol regulation; neuroendocrine regulation and behavior; sperm and testicular function; reproductive biology and fertility; as well as the relationships between health, environment, and cognitive aging.

Key recent publications include:

  • "Impact of Parental Exposure on Offspring Health in Humans," 2020, Trends in Genetics
  • "Epigenetics of childhood trauma: Long term sequelae and potential for treatment," 2021, Neuroscience & Biobehavioral Reviews
  • "Single-Cell Multiomics Techniques: From Conception to Applications," 2022, Frontiers in Cell and Developmental Biology
  • "Long-Term Impact of Social Isolation and Molecular Underpinnings," 2020, Frontiers in Genetics
  • "Involvement of circulating factors in the transmission of paternal experiences through the germline," 2020, The EMBO Journal

Frequent coauthors collaborating on Mansuy's research include Francesca Manuella, Rodrigo G. Arzate-Mejía, Ali Jawaid, Martin Roszkowski, and Leonard C. Steg.

Publication venues where Mansuy has been repeatedly published include bioRxiv (Cold Spring Harbor Laboratory), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Current Zoology, Frontiers in Cell and Developmental Biology, and Frontiers in Genetics.

Isabelle M. Mansuy holds memberships in notable scientific organizations, including the European Academy of Sciences since 2017 and the European Molecular Biology Organization (EMBO).

Best Publications

  • Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

    Mark J. Millan;Yves Agid;Martin Brüne;Edward T. Bullmore

  • Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

    Katharina Gapp;Ali M Jawaid;Peter Sarkies;Johannes Bohacek

  • Epigenetic transmission of the impact of early stress across generations.

    Tamara B. Franklin;Holger Russig;Holger Russig;Isabelle C. Weiss;Isabelle C. Weiss;Johannes Gräff

  • Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.

    Mary Elizabeth Bach;Mark Barad;Hyeon Son;Min Zhuo

  • Neural mechanisms of stress resilience and vulnerability.

    Tamara B. Franklin;Bechara J. Saab;Isabelle M. Mansuy

  • Protein phosphatase 1 is a molecular constraint on learning and memory

    David Genoux;Ursula Haditsch;Marlen Knobloch;Aubin Michalon

  • Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin

    Gaël Malleret;Ursula Haditsch;David Genoux;Matthew W. Jones

  • Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

    Isabelle M Mansuy;Mark Mayford;Betsy Jacob;Eric R Kandel

  • Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

    Danny G Winder;Isabelle M Mansuy;Mona Osman;Theodore M Moallem

  • Epigenetic codes in cognition and behaviour.

    Johannes Gräff;Isabelle M. Mansuy

  • Dendritic spine loss and synaptic alterations in Alzheimer's disease.

    Marlen Knobloch;Isabelle M. Mansuy

  • Molecular insights into transgenerational non-genetic inheritance of acquired behaviours

    Johannes Bohacek;Isabelle M. Mansuy

  • Calcineurin-Mediated LTD of GABAergic Inhibition Underlies the Increased Excitability of CA1 Neurons Associated with LTP

    You Ming Lu;Isabelle M Mansuy;Eric R Kandel;John Roder

  • The γ2 subunit of GABAA receptors is required for maintenance of receptors at mature synapses

    Claude Schweizer;Claude Schweizer;Sylvia Balsiger;Horst Bluethmann;Isabelle M. Mansuy

  • Prion protein and Aβ‐related synaptic toxicity impairment

    Anna Maria Calella;Mélissa Farinelli;Mario Ulisse Nuvolone;Mario Ulisse Nuvolone;Osvaldo Mirante

  • Inducible and Reversible Gene Expression with the rtTA System for the Study of Memory

    Isabelle M Mansuy;Danny G Winder;Theodore M Moallem;Mona Osman

  • Qualitative and Quantitative Analyses of Protein Phosphorylation in Naive and Stimulated Mouse Synaptosomal Preparations

    Richard P. Munton;Ry Tweedie-Cullen;Magdalena Livingstone-Zatchej;Franziska Weinandy

  • Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation

    Andreas Lüthi;Herman Van Der Putten;Florence M. Botteri;Isabelle M. Mansuy

  • Influence of Early Stress on Social Abilities and Serotonergic Functions across Generations in Mice

    Tamara B. Franklin;Natacha Linder;Holger Russig;Beat Thöny

  • Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene.

    Nobuhiko Kojima;Jian Wang;Isabelle M. Mansuy;Seth G. N. Grant

Frequent Co-Authors

Eric R. Kandel
Eric R. Kandel Columbia University
Mark Mayford
Mark Mayford University of California, San Diego
Markus Rudin
Markus Rudin ETH Zurich
Eric A. Miska
Eric A. Miska University of Cambridge
Danny G. Winder
Danny G. Winder Vanderbilt University
Patrick Dutar
Patrick Dutar University of Paris-Saclay
Mark A. Geyer
Mark A. Geyer University of California, San Diego
Victoria B. Risbrough
Victoria B. Risbrough University of California, San Diego
Fritjof Helmchen
Fritjof Helmchen University of Zurich
Michael A. Rapp
Michael A. Rapp University of Potsdam

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