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Stefan G. Sarafianos

Stefan G. Sarafianos

D-Index & Metrics

Molecular Biology

D-Index
64
Citations
12972
World Ranking
1756
National Ranking
880

Overview

Stefan G. Sarafianos is affiliated with the University of Missouri in the United States. Their research primarily centers on medicine, biochemistry, genetics and molecular biology, and immunology and microbiology. Within these broad fields, they focus notably on infectious diseases, molecular biology, virology, hepatology, and epidemiology.

Their work extensively covers topics related to HIV research and treatment, HIV/AIDS drug development and treatment, and hepatitis C virus research. Additional areas include SARS-CoV-2 and COVID-19 research, computational drug discovery methods, HIV/AIDS research and interventions, and RNA research and splicing.

Frequent coauthors collaborating with the scientist include Philip R. Tedbury, Karen A. Kirby, William M. McFadden, Huanchun Zhang, and Shuiyun Lan.

They have published numerous papers in leading journals and publication venues. Their frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Viruses
  • Nature Communications
  • European Journal of Medicinal Chemistry
  • Science Advances

Significant recent papers authored or coauthored by Stefan G. Sarafianos include:

  • HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains, 2020, Nature Communications
  • Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase, 2021, Microorganisms
  • Avoiding Drug Resistance in HIV Reverse Transcriptase, 2021, Chemical Reviews
  • The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr, 2021, Cell Host & Microbe
  • Rotten to the core: antivirals targeting the HIV-1 capsid core, 2021, Retrovirology

Best Publications

  • Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

    Stefan G. Sarafianos;Bruno Marchand;Kalyan Das;Daniel M. Himmel

  • Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.

    Stefan G. Sarafianos;Kalyan Das;Chris Tantillo;Arthur D. Clark

  • Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids

    Stefan G. Sarafianos;Kalyan Das;Arthur D. Clark;Jianping Ding

  • Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution.

    Jianping Ding;Kalyan Das;Yu Hsiou;Stefan G Sarafianos

  • Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC)

    Kalyan Das;Xiaofeng Xiong;Huiling Yang;Christopher E. Westland

  • Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase.

    Paul L. Boyer;Stefan G. Sarafianos;Edward Arnold;Stephen H. Hughes

  • The RNA Polymerase “Switch Region” Is a Target for Inhibitors

    Jayanta Mukhopadhyay;Kalyan Das;Kalyan Das;Sajida Ismail;Sajida Ismail;David Koppstein;David Koppstein

  • X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

    Anna T. Gres;Karen A. Kirby;Vineet N. KewalRamani;John J. Tanner

  • Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation

    Steven Tuske;Steven Tuske;Stefan G. Sarafianos;Stefan G. Sarafianos;Xinyue Wang;Xinyue Wang;Brian Hudson;Brian Hudson

  • Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

    Stefan G. Sarafianos;Arthur D. Clark;Kalyan Das;Steve Tuske

  • Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design

    Xiang Xu;Yunqing Liu;Susan Weiss;Eddy Arnold

  • Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

    Vasudevan Achuthan;Jill M. Perreira;Gregory A. Sowd;Maritza Puray-Chavez

  • Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Entry That Act by Three Distinct Mechanisms

    Adeyemi O. Adedeji;William Severson;Colleen Jonsson;Kamalendra Singh

  • Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.

    Steve Tuske;Steve Tuske;Stefan G Sarafianos;Stefan G Sarafianos;Arthur D Clark;Arthur D Clark;Jianping Ding;Jianping Ding;Jianping Ding

  • Mechanism of nucleic acid unwinding by SARS-CoV helicase.

    Adeyemi O. Adedeji;Bruno Marchand;Aartjan J. W. te Velthuis;Eric J. Snijder

  • The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

    Hong Qiang Gao;Paul L. Boyer;Stefan G. Sarafianos;Edward Arnold

  • Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases.

    Stefan G Sarafianos;Kalyan Das;Stephen H Hughes;Eddy Arnold

  • HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.

    Daniel M. Himmel;Stefan G. Sarafianos;Stefan G. Sarafianos;Sanjeewa Dharmasena;Mohammed M. Hossain

  • Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site

    Stefan G. Sarafianos;Kalyan Dasi;Jianping Dingi;Paul L. Boyer

  • Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.

    Sanjeev Kumar V. Vernekar;Zheng Liu;Eva Nagy;Lena Miller

Frequent Co-Authors

Eddy Arnold
Eddy Arnold Rutgers, The State University of New Jersey
Stephen Hughes
Stephen Hughes National Cancer Institute
Kalyan Das
Kalyan Das Rega Institute for Medical Research
Hiroaki Mitsuya
Hiroaki Mitsuya Kumamoto University
Masao Matsuoka
Masao Matsuoka Kumamoto University
Jianping Ding
Jianping Ding Chinese Academy of Sciences
Susan R. Weiss
Susan R. Weiss University of Pennsylvania
Mark A. Wainberg
Mark A. Wainberg McGill University
Roger A. Jones
Roger A. Jones Rutgers, The State University of New Jersey
Shinichi Oka
Shinichi Oka Kumamoto University

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