World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
87
Citations
27590
World Ranking
2405
National Ranking
850

Research.com Recognitions

  • 2005 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Arun K. Ghosh is affiliated with Purdue University West Lafayette in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Molecular Biology, Infectious Diseases, Organic Chemistry, Materials Chemistry, and Virology.

The scientist's work encompasses a range of topics including:

  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • Computational Drug Discovery Methods
  • Synthetic Organic Chemistry Methods
  • SARS-CoV-2 and COVID-19 Research
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography

Among their recent papers are:

  • Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics, 2020, ChemMedChem
  • Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies, 2021, Journal of Medicinal Chemistry

Frequent co-authors who have collaborated with Ghosh include:

  • Hiroaki Mitsuya
  • Monika Yadav
  • Andrew D. Mesecar
  • Shin-ichiro Hattori
  • Melissa S. Jurica

The scientist often publishes in venues like:

  • The Cambridge Structural Database
  • The Journal of Organic Chemistry
  • European Journal of Medicinal Chemistry
  • Organic & Biomolecular Chemistry
  • ChemMedChem

Arun K. Ghosh has also received recognition within their field, being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2005.

Best Publications

  • C2-Symmetric chiral bis(oxazoline)-metal complexes in catalytic asymmetric synthesis.

    Arun K. Ghosh;Packiarajan Mathivanan;John Cappiello

  • Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

    Lin Hong;Gerald Koelsch;Xinli Lin;Shili Wu

  • Organic carbamates in drug design and medicinal chemistry.

    Arun K. Ghosh;Margherita Brindisi

  • A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

    Kiira Ratia;Scott Pegan;Jun Takayama;Katrina Sleeman

  • Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro

    Yasuhiro Koh;Hirotomo Nakata;Kenji Maeda;Hiromi Ogata

  • Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

    Arun K. Ghosh;Heather L. Osswald;Gary Prato

  • Developing β-secretase inhibitors for treatment of Alzheimer’s disease

    Arun K. Ghosh;Margherita Brindisi;Jordan Tang

  • BACE1 (β-Secretase) Inhibitors for the Treatment of Alzheimer's Disease

    Arun K. Ghosh;Heather L. Osswald

  • Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

    Arun K Ghosh;Margherita Brindisi;Margherita Brindisi

  • The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

    Donald E. Pryor;§ Aurora O'Brate;Geoffrey Bilcer;J. Fernando Díaz

  • Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase).

    Arun K Ghosh;Dongwoo Shin;Debbie Downs;Gerald Koelsch

  • Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)

    Arun K. Ghosh;Geoffrey Bilcer;Cynthia Harwood;Reiko Kawahama

  • Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance.

    Arun K. Ghosh;Bruno D. Chapsal;Irene T. Weber;Hiroaki Mitsuya

  • High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.

    Yunfeng Tie;Peter I. Boross;Peter I. Boross;Yuan-Fang Wang;Laquasha Gaddis

  • Darunavir, a Conceptually New HIV-1 Protease Inhibitor for the Treatment of Drug-resistant HIV

    Arun K. Ghosh;Zachary L. Dawson;Hiroaki Mitsuya

  • Total Synthesis of (±)-Ginkgolide B.

    Elias J. Corey;Myung Chol. Kang;Manoj C. Desai;Arun K. Ghosh

  • Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics.

    Arun K. Ghosh;Margherita Brindisi;Margherita Brindisi;Dana Shahabi;Mackenzie E. Chapman

  • Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

    R T Turner rd;G Koelsch;L Hong;P Castanheira

  • Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3†

    Lin Hong;Robert T. Turner;Gerald Koelsch;Dongoo Shin

  • β-Secretase as a Therapeutic Target for Alzheimer’s Disease

    Arun K. Ghosh;Sandra Gemma;Jordan Tang;Jordan Tang

  • Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

    Arun K Ghosh;John F Kincaid;Wonhwa Cho;D.Eric Walters

Frequent Co-Authors

Hiroaki Mitsuya
Hiroaki Mitsuya Kumamoto University
Jordan Tang
Jordan Tang Oklahoma Medical Research Foundation
Irene T. Weber
Irene T. Weber Georgia State University
Andrew D. Mesecar
Andrew D. Mesecar Purdue University West Lafayette
Sandra Gemma
Sandra Gemma University of Siena
Sambasivarao Kotha
Sambasivarao Kotha Indian Institute of Technology Bombay
Joseph P. Vacca
Joseph P. Vacca MSD (United States)
Xiao Ming Xu
Xiao Ming Xu Indiana University
Susan C. Baker
Susan C. Baker Loyola University Chicago
Andrey Kovalevsky
Andrey Kovalevsky Oak Ridge National Laboratory

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