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Sandra Gemma

Sandra Gemma

D-Index & Metrics

Chemistry

D-Index
44
Citations
5605
World Ranking
17019
National Ranking
664

Overview

Sandra Gemma is affiliated with the University of Siena in Italy and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work is focused on several subfields including Molecular Biology, Organic Chemistry, Oncology, Epidemiology, and Pharmacology.

Their research spans a variety of topics, notably:

  • Histone Deacetylase Inhibitors Research
  • Peptidase Inhibition and Analysis
  • Cannabis and Cannabinoid Research
  • Synthesis and biological activity
  • Research on Leishmaniasis Studies
  • Click Chemistry and Applications
  • Neuroscience and Neuropharmacology Research

Notable recent papers authored or co-authored by Sandra Gemma include:

  • Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists, 2020, Journal of Medicinal Chemistry
  • Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials, 2020, Current Topics in Medicinal Chemistry
  • Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors, 2021, Journal of Medicinal Chemistry
  • Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases, 2022, Molecules
  • Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation, 2020, European Journal of Medicinal Chemistry

Frequent publication venues for Sandra Gemma include:

  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • Molecules
  • ACS Chemical Neuroscience
  • ChemMedChem

Collaborations have been established with recurring co-authors such as:

  • Giuseppe Campiani
  • Stefania Butini
  • Gabriele Carullo
  • Simone Brogi
  • Sara Rossi

Best Publications

  • β-Secretase as a Therapeutic Target for Alzheimer’s Disease

    Arun K. Ghosh;Sandra Gemma;Jordan Tang;Jordan Tang

  • Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.

    Sandra Gemma;Gagan Kukreja;Caterina Fattorusso;Marco Persico

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

    Arduino A. Mangoni;Catherine Guillou;Jean Jacques Vanden Eynde;Christopher Hulme

  • Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease.

    Lhassane Ismaili;Bernard Refouvelet;Mohamed Benchekroun;Simone Brogi

  • Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure−Activity Relationships, and Biological Studies

    Giuseppe Campiani;E. Morelli;Sandra Gemma;Vito Nacci

  • Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists.

    Stefano Federico;Luca Pozzetti;Alessandro Papa;Gabriele Carullo

  • Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases.

    Margherita Brindisi;A. Prasanth Saraswati;Simone Brogi;Sandra Gemma

  • Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

    Giovanni Maga;Sandra Gemma;Caterina Fattorusso;Giada A. Locatelli

  • Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.

    Giuseppe Campiani;Stefania Butini;Francesco Trotta;Caterina Fattorusso

  • Design, Synthesis, and Structure–Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents

    Caterina Fattorusso;Giuseppe Campiani;Gagan Kukreja;Marco Persico

  • Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases.

    Samuele Maramai;Sandra Gemma;Simone Brogi;Giuseppe Campiani

  • Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

    Margherita Brindisi;Samuele Maramai;Sandra Gemma;Simone Brogi

  • Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.

    Stefania Butini;Sandra Gemma;Giuseppe Campiani;Silvia Franceschini

  • Polypharmacology of dopamine receptor ligands

    Stefania Butini;K Nikolic;S Kassel;H Brückmann

  • Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies.

    Sandra Gemma;Luisa Savini;Maria Altarelli;Pierangela Tripaldi

  • Combining 4-Aminoquinoline- and Clotrimazole-Based Pharmacophores toward Innovative and Potent Hybrid Antimalarials

    Sandra Gemma;Giuseppe Campiani;Stefania Butini;Bhupendra P. Joshi

  • Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors

    Stefania Butini;Giuseppe Campiani;Marianna Borriello;Sandra Gemma

  • Mimicking the intramolecular hydrogen bond: Synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents

    Sandra Gemma;Sandra Gemma;Caterina Camodeca;Caterina Camodeca;Margherita Brindisi;Margherita Brindisi;Simone Brogi;Simone Brogi

  • Development of Molecular Probes for the Identification of Extra Interaction Sites in the Mid-Gorge and Peripheral Sites of Butyrylcholinesterase (BuChE). Rational Design of Novel, Selective, and Highly Potent BuChE Inhibitors†

    Giuseppe Campiani;Caterina Fattorusso;Stefania Butini;Alessandra Gaeta

  • Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.

    Giuseppe Campiani;Stefania Butini;Caterina Fattorusso;Bruno Catalanotti

  • Discovery of Huperzine A−Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Midgorge Recognition Sites

    Sandra Gemma;Emanuele Gabellieri;Paul Huleatt;Caterina Fattorusso

Frequent Co-Authors

Giuseppe Campiani
Giuseppe Campiani University of Siena
Ettore Novellino
Ettore Novellino University of Naples Federico II
Arun K. Ghosh
Arun K. Ghosh Purdue University West Lafayette
Donatella Taramelli
Donatella Taramelli University of Milan
Giovanni Maga
Giovanni Maga National Research Council (CNR)
Vanessa Yardley
Vanessa Yardley London School of Hygiene & Tropical Medicine
Giuseppe Valacchi
Giuseppe Valacchi North Carolina State University
Manfred Jung
Manfred Jung University of Freiburg
Lucia Altucci
Lucia Altucci University of Campania "Luigi Vanvitelli"
Ernesto Fattorusso
Ernesto Fattorusso University of Naples Federico II

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