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Biology and Biochemistry

D-Index
47
Citations
8707
World Ranking
18677
National Ranking
7636

Research.com Recognitions

  • 1998 - Hellman Fellow

Overview

Raffi V. Aroian is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans several interconnected fields, primarily focusing on biochemistry, genetics, molecular biology, immunology, and microbiology.

The scientist's work contributes significantly to parasitology, molecular biology, and small animal studies, with additional involvement in ecology and insect science. Their main topics of research include helminth infection and control, parasite biology and host interactions, genetics, aging, and longevity in model organisms, insect resistance and genetics, gut microbiota and health, and the use of entomopathogenic microorganisms in pest control.

Recent publications by Raffi V. Aroian demonstrate a focus on antiparasitic treatments and host-parasite interactions. Examples include:

  • "Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes," 2020, published in Molecules
  • "A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep," 2020, published in the International Journal for Parasitology Drugs and Drug Resistance
  • "Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains," 2023, published in PLoS Pathogens
  • "Nematode ascarosides attenuate mammalian type 2 inflammatory responses," 2022, published in the Proceedings of the National Academy of Sciences
  • "An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals," 2021, published in One Health

Frequent co-authors collaborating with Raffi V. Aroian include:

  • Hanchen Li
  • Gary R. Ostroff
  • Yan Hu
  • David Gazzola
  • Florentina Rus

Aroian's publications often appear in venues such as bioRxiv (Cold Spring Harbor Laboratory), PLoS Pathogens, ACS Infectious Diseases, International Journal for Parasitology, and Molecules.

In recognition of their work, Raffi V. Aroian was awarded the Hellman Fellow honor in 1998.

Best Publications

  • Bacillus thuringiensis crystal proteins that target nematodes

    Jun-Zhi Wei;Kristina Hale;Lynn Carta;Edward Platzer

  • The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

    Raffi V. Aroian;Makoto Koga;Jane E. Mendel;Yasumi Ohshima

  • Glycolipids as receptors for Bacillus thuringiensis crystal toxin.

    Joel S. Griffitts;Stuart M. Haslam;Tinglu Yang;Stephan F. Garczynski

  • Role of Pore-Forming Toxins in Bacterial Infectious Diseases

    Ferdinand C. O. Los;Tara M. Randis;Raffi V. Aroian;Adam J. Ratner

  • Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.

    Danielle L. Huffman;Laurence Abrami;Roman Sasik;Jacques Corbeil

  • Bacillus thuringiensis (Bt) Toxin Susceptibility and Isolation of Resistance Mutants in the Nematode Caenorhabditis elegans

    Lisa D. Marroquin;Dino Elyassnia;Joel S. Griffitts;Jerald S. Feitelson

  • Bt Toxin Resistance from Loss of a Putative Carbohydrate-Modifying Enzyme

    Joel S. Griffitts;Johanna L. Whitacre;Daniel E. Stevens;Raffi V. Aroian

  • The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.

    Min Han;R. V. Aroian;P. W. Sternberg

  • Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.

    R V Aroian;P W Sternberg

  • Many roads to resistance: how invertebrates adapt to Bt toxins

    Joel S. Griffitts;Raffi V. Aroian

  • Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.

    Larry J. Bischof;Cheng-Yuan Kao;Ferdinand C. O. Los;Manuel R. Gonzalez

  • Global Functional Analyses of Cellular Responses to Pore-Forming Toxins

    Cheng-Yuan Kao;Ferdinand C. O. Los;Danielle L. Huffman;Shinichiro Wachi

  • Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants.

    Keir M. Balla;Geanncarlo Lugo-Villarino;Jan M. Spitsbergen;David L. Stachura

  • Pore-forming toxins and cellular non-immune defenses (CNIDs)

    Raffi Aroian;FG van der Goot

  • Resistance to a Bacterial Toxin Is Mediated by Removal of a Conserved Glycosylation Pathway Required for Toxin-Host Interactions

    Joel S. Griffitts;Danielle L. Huffman;Johanna L. Whitacre;Brad D. Barrows

  • Resistance to root-knot nematode in tomato roots expressing a nematicidal Bacillus thuringiensis crystal protein.

    Xiang-Qian Li;Jun-Zhi Wei;Anderson Tan;Raffi V. Aroian

  • The coronin-like protein POD-1 is required for anterior–posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans

    Chad A. Rappleye;Alexander R. Paredez;Carol W. Smith;Kent L. McDonald

  • RAB-5- and RAB-11-Dependent Vesicle-Trafficking Pathways Are Required for Plasma Membrane Repair after Attack by Bacterial Pore-Forming Toxin

    Ferdinand C.O. Los;Cheng-Yuan Kao;Jane Smitham;Kent L. McDonald

  • The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist.

    Yan Hu;Shu-Hua Xiao;Raffi V. Aroian

  • A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum

    Michael Cappello;Richard D. Bungiro;Lisa M. Harrison;Larry J. Bischof

Frequent Co-Authors

Paul W. Sternberg
Paul W. Sternberg California Institute of Technology
Joseph F. Urban
Joseph F. Urban United States Department of Agriculture
Victor Nizet
Victor Nizet University of California, San Diego
Steven A. Williams
Steven A. Williams Smith College
Kent L. McDonald
Kent L. McDonald University of California, Berkeley
Paul J. Brindley
Paul J. Brindley George Washington University
Anne Dell
Anne Dell Imperial College London
Makedonka Mitreva
Makedonka Mitreva Washington University in St. Louis
Martin K. Nielsen
Martin K. Nielsen Aarhus University
Anne M. Zajac
Anne M. Zajac Virginia Tech

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