John C. Lawrence

Overview

Best Publications

• Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.

  Sue C. Bodine;Trevor N. Stitt;Michael Gonzalez;William O. Kline

  3112
  Citations

• Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

  Arnim Pause;Graham J. Belsham;Anne Claude Gingras;Olivier Donzé

  1588
  Citations

• Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

  Gregory J. Brunn;Christine C. Hudson;Aleksandar Sekulić;Aleksandar Sekulić;Aleksandar Sekulić;Josie M. Williams

  1197
  Citations

• Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

  G. J. Brunn;J. Williams;C. Sabers;G. Wiederrecht

  899
  Citations

• PHAS-I as a link between mitogen-activated protein kinase and translation initiation.

  Tai-An Lin;Xianming Kong;Timothy A. J. Haystead;Arnim Pause

  831
  Citations

• PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding

  Lifu Wang;Thurl E. Harris;Richard A. Roth;John C. Lawrence

  655
  Citations

• Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway

  Brian N. Finck;Matthew C. Gropler;Zhouji Chen;Teresa C. Leone

  639
  Citations

• Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

  Pamela H. Scott;Gregory J. Brunn;Aimee D. Kohn;Richard A. Roth

  612
  Citations

• Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid

  Betty A. Maddux;Wendy See;John C. Lawrence;Amy L. Goldfine

  559
  Citations

• Increasing cAMP attenuates activation of mitogen-activated protein kinase

  Bradley R. Sevetson;Xianming Kong;John C. Lawrence

  474
  Citations

• New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

  John C Lawrence;Peter J Roach

  392
  Citations

• Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

  Aimee D. Kohn;Andreas Barthel;Kristina S. Kovacina;Annegret Boge

  378
  Citations

• Control of Ser2448 Phosphorylation in the Mammalian Target of Rapamycin by Insulin and Skeletal Muscle Load

  Thomas H. Reynolds;Sue C. Bodine;John C. Lawrence

  345
  Citations

• Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin

  Todd A. Huffman;Isabelle Mothe-Satney;John C. Lawrence

  306
  Citations

• Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

  Anil Kumar;John C. Lawrence;Dae Young Jung;Hwi Jin Ko

  305
  Citations

• Control of PHAS-I by Insulin in 3T3-L1 Adipocytes SYNTHESIS, DEGRADATION, AND PHOSPHORYLATION BY A RAPAMYCIN-SENSITIVE AND MITOGEN- ACTIVATED PROTEIN KINASE-INDEPENDENT PATHWAY

  Tai An Lin;Xianming Kong;Alan R. Saltiel;Perry J. Blackshear

  291
  Citations

• PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

  John C. Lawrence;Robert T. Abraham

  289
  Citations

• Evidence for the Involvement of Sulfhydryl Oxidation in the Regulation of Fat Cell Hexose Transport by Insulin

  Michael P. Czech;John C. Lawrence;William S. Lynn

  280
  Citations

• Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling.

  Guang Xu;Guim Kwon;Connie A. Marshall;Tai-An Lin

  279
  Citations

• Identification of Phosphorylation Sites in the Translational Regulator, PHAS-I, That Are Controlled by Insulin and Rapamycin in Rat Adipocytes

  Patrick Fadden;Timothy A.J. Haystead;John C. Lawrence

  278
  Citations