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Timothy A. J. Haystead

Timothy A. J. Haystead

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
18448
World Ranking
6632
National Ranking
3084

Overview

Timothy A. J. Haystead is affiliated with Duke University in the United States and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research output spans several interconnected subfields including Molecular Biology, Infectious Diseases, Cancer Research, Immunology, and Rheumatology.

Their recent published papers illustrate a focus on molecular mechanisms related to cancer, inflammation, and infectious diseases. Notable papers include:

  • Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1, 2020, Science Translational Medicine
  • TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases, 2020, Open Biology
  • The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect, 2021, Nature Structural & Molecular Biology
  • Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells, 2021, iScience
  • Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors, 2020, Communications Biology

Their frequently studied topics include:

  • Heat shock proteins research
  • NF-κB Signaling Pathways
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Photodynamic Therapy Research Studies
  • Nanoplatforms for cancer theranostics
  • Interferon and immune responses

Timothy A. J. Haystead collaborates regularly with a number of researchers, with frequent co-authors being:

  • Philip F. Hughes
  • Scott A. Scarneo
  • David R. Loiselle
  • Kelly W. Yang
  • David A. Carlson

Their work is frequently published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Journal of Biological Chemistry
  • Cell chemical biology
  • Scientific Reports

Haystead's research integrates multiple disciplines, mainly emphasizing molecular biology and immunology to address cancer biology and infectious disease challenges. Their studies on heat shock proteins and signaling pathways play roles in understanding disease mechanisms and potential therapeutic targets.

Best Publications

  • Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

    T. A. J. Haystead;A. T. R. Sim;D. Carling;R. C. Honnor

  • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

    Paul Dent;Wayne Haser;Timothy A. J. Haystead;Leigh Ann Vincent

  • PHAS-I as a link between mitogen-activated protein kinase and translation initiation.

    Tai-An Lin;Xianming Kong;Timothy A. J. Haystead;Arnim Pause

  • The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

    James P. Grenert;William P. Sullivan;Patrick Fadden;Timothy A.J. Haystead

  • Molecular Biologist's Guide to Proteomics

    Paul R. Graves;Timothy A. J. Haystead;Timothy A. J. Haystead

  • Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice

    Susan B. Gurley;Alicia Allred;Thu H. Le;Robert Griffiths

  • Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance

    Gregory LaMonte;Nisha Philip;Joseph Reardon;Joshua R. Lacsina

  • Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase.

    Pascual Sanz;Geoffrey R. Alms;Timothy A. J. Haystead;Marian Carlson

  • Discovery of novel targets of quinoline drugs in the human purine binding proteome.

    Paul R. Graves;Jesse J. Kwiek;Patrick Fadden;Rupa Ray

  • A conserved family of enzymes that phosphorylate inositol hexakisphosphate

    Sashidhar Mulugu;Sashidhar Mulugu;Wenli Bai;Wenli Bai;Peter C. Fridy;Peter C. Fridy;Robert J. Bastidas;Robert J. Bastidas

  • Smooth Muscle Phosphatase Is Regulated in Vivo by Exclusion of Phosphorylation of Threonine 696 of MYPT1 by Phosphorylation of Serine 695 in Response to Cyclic Nucleotides

    Anne A. Wooldridge;Justin A. MacDonald;Ferenc Erdodi;Chaoyu Ma

  • Identification of Phosphorylation Sites in the Translational Regulator, PHAS-I, That Are Controlled by Insulin and Rapamycin in Rat Adipocytes

    Patrick Fadden;Timothy A.J. Haystead;John C. Lawrence

  • Getting More from Less Algorithms for Rapid Protein Identification with Multiple Short Peptide Sequences

    Aaron J. Mackey;Timothy A.J. Haystead;William R. Pearson

  • Mammalian Septins Regulate Microtubule Stability through Interaction with the Microtubule-binding Protein MAP4

    Brandon E. Kremer;Timothy Haystead;Ian G. Macara

  • Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.

    Isabelle Mothe-Satney;Daqing Yang;Patrick Fadden;Timothy A. J. Haystead

  • Hsp90, an unlikely ally in the war on cancer

    Jared J. Barrott;Timothy A. J. Haystead

  • Identification of the endogenous smooth muscle myosin phosphatase-associated kinase

    Justin A. MacDonald;Meredith A. Borman;Andrea Murányi;Avril V. Somlyo

  • Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle.

    A. Shirazi;K. Iizuka;P. Fadden;C. Mosse

  • Borg proteins control septin organization and are negatively regulated by Cdc42.

    Gérard Joberty;Richard R. Perlungher;Peter J. Sheffield;Makoto Kinoshita;Makoto Kinoshita

  • The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.

    Gregory J. Brunn;Patrick Fadden;Timothy A.J. Haystead;John C. Lawrence

Frequent Co-Authors

Avril V. Somlyo
Avril V. Somlyo University of Virginia
John C. Lawrence
John C. Lawrence University of Virginia
Thomas W. Sturgill
Thomas W. Sturgill University of Virginia
Harry F. Baker
Harry F. Baker University of Cambridge
Rosalind M. Ridley
Rosalind M. Ridley University of Cambridge
Jie Wu
Jie Wu Temple University
H. Kim Lyerly
H. Kim Lyerly Duke University
D. Grahame Hardie
D. Grahame Hardie University of Dundee
Thomas M. Coffman
Thomas M. Coffman Duke University
William R. Pearson
William R. Pearson University of Virginia

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