What is he best known for?
The fields of study he is best known for:
His scientific interests lie mostly in Myosin, Myosin light-chain kinase, Phosphorylation, Biochemistry and Phosphatase.
His studies deal with areas such as Smooth muscle contraction, Protein subunit and Actin as well as Myosin.
In general Myosin light-chain kinase, his work in Telokin is often linked to Antiparallel linking many areas of study.
David J. Hartshorne interconnects Molecular biology, Kinase and RHOA in the investigation of issues within Phosphorylation.
Meromyosin and Protein phosphorylation are subfields of Biochemistry in which his conducts study.
His Phosphatase research is classified as research in Enzyme.
His most cited work include:
- Calyculin A and okadaic acid: inhibitors of protein phosphatase activity (898 citations)
- Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. (576 citations)
- Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase (472 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Myosin, Myosin light-chain kinase, Biochemistry, Phosphorylation and Phosphatase.
His biological study spans a wide range of topics, including Dephosphorylation, Rho-associated protein kinase and Actin.
Myosin light-chain kinase is the subject of his research, which falls under Cell biology.
His research on Biochemistry often connects related areas such as Muscle contraction.
David J. Hartshorne combines subjects such as Immunoglobulin light chain, ATPase, Kinase and RHOA with his study of Phosphorylation.
His Phosphatase study combines topics in areas such as Molecular biology, Protein subunit, Protein phosphorylation and MYH7.
He most often published in these fields:
- Myosin (64.66%)
- Myosin light-chain kinase (58.65%)
- Biochemistry (58.65%)
What were the highlights of his more recent work (between 2001-2015)?
- Myosin (64.66%)
- Myosin light-chain kinase (58.65%)
- Phosphatase (39.10%)
In recent papers he was focusing on the following fields of study:
David J. Hartshorne mainly focuses on Myosin, Myosin light-chain kinase, Phosphatase, Phosphorylation and Biochemistry.
Specifically, his work in Myosin is concerned with the study of Myosin-light-chain phosphatase.
To a larger extent, he studies Cell biology with the aim of understanding Myosin light-chain kinase.
His Phosphatase research incorporates themes from Retinoblastoma protein, Protein subunit and MYH7.
As part of the same scientific family, David J. Hartshorne usually focuses on Phosphorylation, concentrating on RHOA and intersecting with Protein kinase C.
In his study, cGMP-dependent protein kinase, Smooth muscle contraction and Myosin phosphatase activity is strongly linked to Vascular smooth muscle, which falls under the umbrella field of Biochemistry.
Between 2001 and 2015, his most popular works were:
- Myosin phosphatase: structure, regulation and function. (378 citations)
- Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts (330 citations)
- Activation of RhoA and Inhibition of Myosin Phosphatase as Important Components in Hypertension in Vascular Smooth Muscle (289 citations)
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