World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
25005
World Ranking
3493
National Ranking
1755

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

David L. Brautigan is affiliated with the University of Virginia in the United States and conducts research primarily in the fields of Biochemistry, Genetics, and Molecular Biology, with a significant focus also on Medicine. Their studies encompass key subfields such as Molecular Biology, Genetics, Hepatology, Cancer Research, and Oncology.

The scientist's recent research output includes work published across various respected venues. Notable papers include:

  • Selective PP2A Enhancement through Biased Heterotrimer Stabilization, 2020, published in Cell
  • A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling, 2021, published in Nature Communications
  • Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations, 2022, published in eLife
  • Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents, 2021, published in Clinical Science
  • Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy, 2020, published in Cells

Their collaborations include frequent coauthors such as Zheng Fu, Goutham Narla, Casey D. Gailey, Sean Ahmadi, and Wenhao Xu.

David L. Brautigan has contributed to research topics spanning:

  • Genetic and Kidney Cyst Diseases
  • Hedgehog Signaling Pathway Studies
  • Renal and related cancers
  • Biochemical and Molecular Research
  • Epigenetics and DNA Methylation
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Cancer, Hypoxia, and Metabolism

They have published in frequent venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Vascular and Interventional Radiology, Cells, Cell, and Nature Communications.

In 2016, David L. Brautigan was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Raf-1 activates MAP kinase-kinase.

    John M. Kyriakis;Harald App;Xian-feng Zhang;Papia Banerjee

  • Calyculin A and okadaic acid: inhibitors of protein phosphatase activity

    H. Ishihara;B.L. Martin;D.L. Brautigan;H. Karaki

  • Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

    David C. Pallas;Lilian K. Shahrik;Bruce L. Martin;Stephen Jaspers

  • Regulation of Protein Serine-Threonine Phosphatase Type-2A by Tyrosine Phosphorylation

    Jian Chen;Bruce L. Martin;David L. Brautigan

  • Correlation of the kinetics of electron transfer activity of various eukaryotic cytochromes c with binding to mitochondrial cytochrome c oxidase.

    S Ferguson-Miller;D L Brautigan;E Margoliash

  • Definition of cytochrome c binding domains by chemical modification. III. Kinetics of reaction of carboxydinitrophenyl cytochromes c with cytochrome c oxidase.

    S Ferguson-Miller;D L Brautigan;E Margoliash

  • [18] Mitochondrial cytochrome c: Preparation and activity of native and chemically modified cytochromes c

    David L. Brautigan;Shelagh Ferguson-Miller;E. Margoliash

  • Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility

    Toshio Kitazawa;Masumi Eto;Terence P. Woodsome;David L. Brautigan

  • Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient.

    Brian G. Fuller;Michael A. Lampson;Emily A. Foley;Sara Rosasco-Nitcher

  • Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.

    D L Brautigan;P Bornstein;B Gallis

  • Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

    Jian Chen;S. Parsons;D. L. Brautigan

  • Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phosphatase 2A

    Peter H. Reinhart;Sungkwon Chung;Bruce L. Martin;David L. Brautigan

  • B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

    Kohei Murata;Jun Wu;David L. Brautigan

  • Expression of CPI-17 and myosin phosphatase correlates with Ca2+ sensitivity of protein kinase C-induced contraction in rabbit smooth muscle

    Terence P. Woodsome;Masumi Eto;Allen D Everett;David L. Brautigan

  • Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A

    Lu-Yang Wang;Bev A. Orser;David L. Brautigan;John F. MacDonald

  • Protein Ser/ Thr phosphatases – the ugly ducklings of cell signalling

    David L. Brautigan

  • The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases.

    Bo Zhou;Zhi Xin Wang;Yu Zhao;David L. Brautigan

  • Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit.

    A. Fernandez;D. L. Brautigan;N. J. C. Lamb

  • Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel.

    Sungkwon Chung;Peter H. Reinhart;Bruce L. Martin;David Brautigan

  • Histamine-induced Vasoconstriction Involves Phosphorylation of a Specific Inhibitor Protein for Myosin Phosphatase by Protein Kinase C α and δ Isoforms

    Masumi Eto;Toshio Kitazawa;Michio Yazawa;Hideyuki Mukai

Frequent Co-Authors

Dan Theodorescu
Dan Theodorescu University of Arizona
Shirish Shenolikar
Shirish Shenolikar Duke University
Craig L. Slingluff
Craig L. Slingluff University of Virginia
Shelagh Ferguson-Miller
Shelagh Ferguson-Miller Michigan State University
Goutham Narla
Goutham Narla University of Michigan–Ann Arbor
Joseph Larner
Joseph Larner University of Virginia
P. Todd Stukenberg
P. Todd Stukenberg University of Virginia
Edmond H. Fischer
Edmond H. Fischer University of Washington
Wenqing Xu
Wenqing Xu University of Washington
Bryce M. Paschal
Bryce M. Paschal University of Virginia

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