2026 Karnam S. Murthy: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	61	11622	10703	5003	4479	245	9693

Overview

Karnam S. Murthy is affiliated with Virginia Commonwealth University in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology.

The scientist has contributed to several fields of study, including:

Medicine
Biochemistry, Genetics and Molecular Biology

Within these main fields, they have focused on specific subfields such as:

Cell Biology
Surgery
Infectious Diseases
Immunology
Molecular Biology

Their main research topics cover a diverse range that includes:

Endoplasmic Reticulum Stress and Disease
Pancreatitis Pathology and Treatment
Phagocytosis and Immune Regulation
Muscle Physiology and Disorders
Exercise and Physiological Responses
Muscle metabolism and nutrition
COVID-19 Clinical Research Studies

Karnam S. Murthy has published multiple papers in peer-reviewed journals with a focus on medical and physiological studies. Notable recent publications include:

"Endoplasmic Reticulum Stress in Subepithelial Myofibroblasts Increases the TGF-β1 Activity That Regulates Fibrosis in Crohn's Disease," 2020, published in Inflammatory Bowel Diseases
"Decreased smooth muscle function, peristaltic activity, and gastrointestinal transit in dystrophic (mdx) mice," 2020, published in Neurogastroenterology & Motility
"COVID-19 and gastrointestinal system: A brief review," 2021, published in Biomedical Journal
"Obituary for Dr. Gabriel M. Makhlouf," 2021, published in Neurogastroenterology & Motility

Frequent co-authors collaborating with Karnam S. Murthy include:

John R. Grider
Chao Li
Jaime L. Bohl
Emily B. Rivet
Nicole Wieghard

They have published most frequently in the following academic venues:

Neurogastroenterology & Motility
Inflammatory Bowel Diseases
Biomedical Journal

Best Publications

SIGNALING FOR CONTRACTION AND RELAXATION IN SMOOTH MUSCLE OF THE GUT

Karnam S. Murthy

460
Citations
Stimulation of nitric oxide from muscle cells by VIP: prejunctional enhancement of VIP release

J. R. Grider;K. S. Murthy;J. G. Jin;G. M. Makhlouf

345
Citations
Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells.

Divya P. Kumar;Senthilkumar Rajagopal;Sunila Mahavadi;Faridoddin Mirshahi

212
Citations
Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway.

Karnam S Murthy;Huiping Zhou;John R Grider;David L Brautigan

212
Citations
Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells

B.-Q. Teng;K. S. Murthy;J. F. Kuemmerle;J. R. Grider

183
Citations
Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle.

K S Murthy;G M Makhlouf

180
Citations
Somatostatin Receptor-mediated Signaling in Smooth Muscle ACTIVATION OF PHOSPHOLIPASE C-β3 BY Gβγ AND INHIBITION OF ADENYLYL CYCLASE BY Gαi1 AND Gαo

Karnam S. Murthy;David H. Coy;Gabriel M. Makhlouf

177
Citations
Gi-1/Gi-2-dependent signaling by single-transmembrane natriuretic peptide clearance receptor

K. S. Murthy;B.-Q. Teng;H. Zhou;J.-G. Jin

168
Citations
G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor

K. S. Murthy;B.-Q. Teng;J.-G. Jin;G. M. Makhlouf

161
Citations
Identification of the G Protein-activating Domain of the Natriuretic Peptide Clearance Receptor (NPR-C)

Karnam S. Murthy;Gabriel M. Makhlouf

157
Citations
SIGNAL TRANSDUCTION IN GASTROINTESTINAL SMOOTH MUSCLE

Gabriel M Makhlouf;Karnam S Murthy

154
Citations
Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA

Karnam S. Murthy;Huiping Zhou;John R. Grider;Gabriel M. Makhlouf

154
Citations
Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2.

K.S. Murthy;G.M. Makhlouf

152
Citations
Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells

K. S. Murthy;G. M. Makhlouf

151
Citations
Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells.

Hans M Rosenfeldt;Yassine Amrani;Kenneth R Watterson;Karnam S Murthy

150
Citations
Coexpression of Ligand-gated P2X and G Protein-coupled P2Y Receptors in Smooth Muscle PREFERENTIAL ACTIVATION OF P2Y RECEPTORS COUPLED TO PHOSPHOLIPASE C (PLC)-β1 VIA Gαq/11 AND TO PLC-β3 VIA Gβγi3

Karnam S. Murthy;Gabriel M. Makhlouf

145
Citations
The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon

Norm R. Hurst;Derek M. Kendig;Karnam S. Murthy;John R. Grider

140
Citations
VIP-mediated G protein-coupled Ca2+ influx activates a constitutive NOS in dispersed gastric muscle cells.

K. S. Murthy;K. M. Zhang;J. G. Jin;J. R. Grider

139
Citations
Gq/G13 signaling by ET-1 in smooth muscle : MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB

Eric Hersch;Jiean Huang;John R. Grider;Karnam S. Murthy

138
Citations
Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2.

Huiping Zhou;Karnam S. Murthy

136
Citations