World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
8032
World Ranking
18933
National Ranking
7734

Overview

John R. Grider is affiliated with Virginia Commonwealth University in the United States. Their research primarily focuses on medicine, with particular emphasis on surgery, cell biology, psychiatry and mental health, gastroenterology, and public health, environmental and occupational health.

The scientist's work covers several main topics including congenital gastrointestinal and neural anomalies, child nutrition and feeding issues, gastrointestinal motility and disorders, biochemical analysis and sensing techniques, olfactory and sensory function studies, advanced chemical sensor technologies, and endoplasmic reticulum stress and disease.

John R. Grider has contributed to a number of recent publications. These include:

  • Kokumi Taste Active Peptides Modulate Salt and Umami Taste, 2020, Nutrients
  • Endoplasmic Reticulum Stress in Subepithelial Myofibroblasts Increases the TGF-β1 Activity That Regulates Fibrosis in Crohn's Disease, 2020, Inflammatory Bowel Diseases
  • Decreased smooth muscle function, peristaltic activity, and gastrointestinal transit in dystrophic (mdx) mice, 2020, Neurogastroenterology & Motility
  • Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models, 2025, Science Translational Medicine
  • BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus, 2023, British Journal of Pharmacology

The frequent coauthors with whom John R. Grider has collaborated include:

  • Karnam S. Murthy
  • Matthew J. Jansen
  • Letitia L. Williams
  • Sophie H. Wang
  • Elizabeth M. Eultgen

The scientist's publications have appeared in venues such as:

  • Neurogastroenterology & Motility
  • Nutrients
  • Inflammatory Bowel Diseases
  • Science Translational Medicine
  • British Journal of Pharmacology

Best Publications

  • Gene Targeting Reveals a Critical Role for Neurturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic Neurons

    Robert O Heuckeroth;Hideki Enomoto;John R Grider;Judith P Golden

  • Stimulation of nitric oxide from muscle cells by VIP: prejunctional enhancement of VIP release

    J. R. Grider;K. S. Murthy;J. G. Jin;G. M. Makhlouf

  • The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice

    Farzad Alemi;Daniel Philip Poole;Jonathon V Chiu;Kristina Schoonjans

  • GDNF availability determines enteric neuron number by controlling precursor proliferation

    Scott Gianino;John R. Grider;Jennifer Cresswell;Hideki Enomoto

  • Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells.

    Divya P. Kumar;Senthilkumar Rajagopal;Sunila Mahavadi;Faridoddin Mirshahi

  • Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway.

    Karnam S Murthy;Huiping Zhou;John R Grider;David L Brautigan

  • Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells

    B.-Q. Teng;K. S. Murthy;J. F. Kuemmerle;J. R. Grider

  • Gi-1/Gi-2-dependent signaling by single-transmembrane natriuretic peptide clearance receptor

    K. S. Murthy;B.-Q. Teng;H. Zhou;J.-G. Jin

  • Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation

    JR Grider;JG Jin

  • Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA

    Karnam S. Murthy;Huiping Zhou;John R. Grider;Gabriel M. Makhlouf

  • Vasoactive intestinal peptide as a neural mediator of gastric relaxation

    J. R. Grider;M. B. Cable;S. I. Said;G. M. Makhlouf

  • The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon

    Norm R. Hurst;Derek M. Kendig;Karnam S. Murthy;John R. Grider

  • VIP-mediated G protein-coupled Ca2+ influx activates a constitutive NOS in dispersed gastric muscle cells.

    K. S. Murthy;K. M. Zhang;J. G. Jin;J. R. Grider

  • Gq/G13 signaling by ET-1 in smooth muscle : MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB

    Eric Hersch;Jiean Huang;John R. Grider;Karnam S. Murthy

  • CGRP as a transmitter in the sensory pathway mediating peristaltic reflex

    J. R. Grider

  • Activation of transmembrane bile acid receptor TGR5 modulates pancreatic islet α cells to promote glucose homeostasis

    Divya P. Kumar;Amon Asgharpour;Faridoddin Mirshahi;So Hyun Park

  • Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S

    Vanitha Bala;Senthilkumar Rajagopal;Divya P. Kumar;Ancy D. Nalli

  • Activation of distinct cAMP- and cGMP-dependent pathways by relaxant agents in isolated gastric muscle cells.

    J. G. Jin;K. S. Murthy;J. R. Grider;G. M. Makhlouf

  • InsP3-dependent Ca2+ mobilization in circular but not longitudinal muscle cells of intestine.

    K. S. Murthy;J. R. Grider;G. M. Makhlouf

  • Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice

    Steven G. Kinsey;Daniel K. Nomura;Scott T. O'Neal;Jonathan Z. Long

Frequent Co-Authors

Karnam S. Murthy
Karnam S. Murthy Virginia Commonwealth University
Huiping Zhou
Huiping Zhou University of Tsukuba
Arun J. Sanyal
Arun J. Sanyal Virginia Commonwealth University
Nigel W. Bunnett
Nigel W. Bunnett New York University
Hongxia Wang
Hongxia Wang Queensland University of Technology
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Kristina Schoonjans
Kristina Schoonjans École Polytechnique Fédérale de Lausanne
Hideki Enomoto
Hideki Enomoto Kobe University
William D. Snider
William D. Snider University of North Carolina at Chapel Hill
John E. Pintar
John E. Pintar Rutgers, The State University of New Jersey

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