World's Best Scientists 2026 revealed!
Keith A. Sharkey

Keith A. Sharkey

D-Index & Metrics

Medicine

D-Index
94
Citations
30182
World Ranking
10533
National Ranking
423

Overview

Keith A. Sharkey is affiliated with the University of Calgary in Canada and has a primary research focus spanning medicine and neuroscience. Their work covers a variety of specialized subfields including gastroenterology, molecular biology, physiology, pharmacology, and neurology.

The scientist's research interests concentrate significantly on gastrointestinal motility and disorders, gut microbiota and health, cannabis and cannabinoid research, diet and metabolism studies, tryptophan and brain disorders, stress responses and cortisol, and congenital gastrointestinal and neural anomalies.

Notable recent publications authored or coauthored by Keith A. Sharkey include:

  • "Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia" (2021) published in Microbiome
  • "The enteric nervous system" (2022) published in Physiological Reviews
  • "Intestinal fungi are causally implicated in microbiome assembly and immune development in mice" (2020) published in Nature Communications
  • "A monocyte-leptin-angiogenesis pathway critical for repair post-infection" (2022) published in Nature
  • "In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity" (2021) published in Neuron

Frequent coauthors who have collaborated extensively with Sharkey include:

  • Fernando Vicentini
  • Catherine M. Keenan
  • Simon A. Hirota
  • Mark G. Swain
  • Laurie E. Wallace

Sharkey's work is frequently published in scientific venues such as the Journal of the Canadian Association of Gastroenterology, American Journal of Physiology-Gastrointestinal and Liver Physiology, Cannabis and Cannabinoid Research, Brain Behavior and Immunity, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors

    Marja D. Van Sickle;Marnie Duncan;Philip J. Kingsley;Abdeslam Mouihate

  • Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome

    Matthew D. Coates;Christine R. Mahoney;David R. Linden;Joanna E. Sampson

  • Endocannabinoid signaling at the periphery: 50 years after THC

    Mauro Maccarrone;Itai Bab;Tamás Bíró;Guy A. Cabral

  • Role for protease activity in visceral pain in irritable bowel syndrome.

    Nicolas Cenac;Christopher N. Andrews;Marinella Holzhausen;Kevin Chapman

  • Recurrent aphthous ulcers today: a review of the growing knowledge

    S.S. Natah;S.S. Natah;Y.T. Konttinen;N.S. Enattah;N. Ashammakhi

  • Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.

    N. Vergnolle;N.W. Bunnett;K.A. Sharkey;V. Brussee

  • Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

    Brian K. Reuter;Samuel Asfaha;André Buret;Keith A. Sharkey

  • Cannabinoids and the Gut: New Developments and Emerging Concepts

    Angelo A. Izzo;Keith A. Sharkey

  • Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.

    Brian D Gulbransen;Mohammad Bashashati;Simon A Hirota;Xianyong Gui

  • Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation

    Kiarash Riazi;Michael A. Galic;J. Brent Kuzmiski;Winnie Ho

  • Cyclooxygenase 1 Contributes to Inflammatory Responses in Rats and Mice: Implications for Gastrointestinal Toxicity

    John L. Wallace;Adrian Bak;Webb McKnight;Samuel Asfaha

  • Novel functional roles for enteric glia in the gastrointestinal tract

    Brian D. Gulbransen;Keith A. Sharkey

  • Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia.

    Michael J. Hickey;Keith A Sharkey;Elaine G. Sihota;Paul H. Reinhardt

  • Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis.

    David R. Linden;Jing Xian Chen;Michael D. Gershon;Keith A. Sharkey

  • Cannabinoid CB2 receptors in the gastrointestinal tract : a regulatory system in states of inflammation

    K L Wright;M Duncan;K A Sharkey

  • Inflammatory neuropathies of the enteric nervous system.

    Roberto De Giorgio;Stefania Guerrini;Giovanni Barbara;Vincenzo Stanghellini

  • Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.

    Jill M. Hoffman;Karl Tyler;Sarah J. MacEachern;Onesmo B. Balemba

  • Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret

    Marja D. Van Sickle;Lorraine D. Oland;Winnie Ho;Cecilia J. Hillard

  • Sensory substance P innervation of the stomach and pancreas: Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing

    K.A. Sharkey;R.G. Williams;G.J. Dockray

  • Enhanced excitability of myenteric AH neurones in the inflamed guinea‐pig distal colon

    David R. Linden;Keith A. Sharkey;Gary M. Mawe

Frequent Co-Authors

Quentin J. Pittman
Quentin J. Pittman University of Calgary
John L. Wallace
John L. Wallace University of Calgary
Ken Mackie
Ken Mackie Indiana University
Beat Lutz
Beat Lutz Johannes Gutenberg University of Mainz
Derek M. McKay
Derek M. McKay University of Calgary
Alexandros Makriyannis
Alexandros Makriyannis Northeastern University
Nima Rezaei
Nima Rezaei Tehran University of Medical Sciences
Glenda MacQueen
Glenda MacQueen University of Calgary
Benjamin F. Cravatt
Benjamin F. Cravatt Scripps Research Institute
Morley D. Hollenberg
Morley D. Hollenberg University of Calgary

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring alternative pathways in healthcare and related fields can open up rewarding careers, especially if you are seeking flexible or affordable options. For registered nurses aiming to advance their education without breaking the bank, the rn to bsn cheapest programs offer accredited routes to higher qualifications at a lower cost.

If you hold a non-nursing bachelor's degree and wish to transition into advanced nursing roles, direct entry msn online programs fast-track your path to a Master of Science in Nursing. These programs are designed for individuals from diverse educational backgrounds who aspire to enter the nursing profession at a higher level.

For those concerned about the competitiveness of applications, discovering what is the easiest nursing school to get into can help you identify programs with more accessible admissions standards, increasing your chances of starting a nursing career sooner.

Alternatively, careers in healthcare administration are also in demand. If you prefer to work outside of direct patient care, consider studying at medical billing and coding schools online with financial aid, where you can gain essential skills for supporting the healthcare system from an administrative perspective.

Best Scientists Citing Keith A. Sharkey

Trending Scientists

Recently Published Articles