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Derek M. McKay

Derek M. McKay

D-Index & Metrics

Microbiology

D-Index
63
Citations
13456
World Ranking
2748
National Ranking
75

Overview

Derek M. McKay is affiliated with the University of Calgary in Canada. Their research primarily spans several fields including Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine. Within these broad areas, their work delves into specialized subfields such as Molecular Biology, Immunology, Parasitology, Surgery, and Genetics.

The scientist's research focuses on key topics that intersect host-pathogen interactions and immune system functions. These topics include:

  • Parasites and Host Interactions
  • Gut microbiota and health
  • Immune Response and Inflammation
  • Inflammatory Bowel Disease
  • Mitochondrial Function and Pathology
  • Immune cells in cancer
  • Metabolomics and Mass Spectrometry Studies

Derek M. McKay has contributed to multiple publications, frequently appearing in venues such as:

  • Journal of the Canadian Association of Gastroenterology
  • American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Gut Microbes
  • Pathogens
  • The FASEB Journal

Notable recent papers authored by or associated with Derek M. McKay include:

  • Perturbed Mitochondrial Dynamics Is a Novel Feature of Colitis That Can Be Targeted to Lessen Disease, 2020, Cellular and Molecular Gastroenterology and Hepatology
  • Human interleukin-4-treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model, 2020, Science Advances
  • Macrophage immunotherapy: overcoming impediments to realize promise, 2022, Trends in Immunology
  • Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production, 2020, Gut Microbes
  • Cooperation between host immunity and the gut bacteria is essential for helminth-evoked suppression of colitis, 2021, Microbiome

Collaboration is a significant part of Derek M. McKay's work. Frequent co-authors include:

  • A Wang
  • Sruthi Rajeev
  • Timothy E. Shutt
  • Arthur Wang
  • André G. Buret

Best Publications

  • Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress

    M Zareie;K Johnson-Henry;J Jury;P-C Yang

  • Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.

    Brian D Gulbransen;Mohammad Bashashati;Simon A Hirota;Xianyong Gui

  • Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate.

    Kimberley Lewis;Femke Lutgendorff;Van Phan;Johan D. Söderholm

  • The Pro-Inflammatory Cytokine, Interleukin-6, Enhances the Polarization of Alternatively Activated Macrophages

    Unknown

  • In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice

    Meaghan M. Hunter;Arthur Wang;Kuljit S. Parhar;Michael J.G. Johnston

  • Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse

    M A Benjamin;D M McKay;P C Yang;H Cameron

  • Corticotropin releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro

    Conny Wallon;Pingchang Yang;Åsa V. Keita;Ann-Charlott Ericson

  • Transforming Growth Factor-β Regulation of Epithelial Tight Junction Proteins Enhances Barrier Function and Blocks Enterohemorrhagic Escherichia coli O157:H7-Induced Increased Permeability

    Kathryn L. Howe;Colin Reardon;Arthur Wang;Aisha Nazli

  • Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine.

    P. R. Saunders;U. Kosecka;D. M. McKay;M. H. Perdue

  • Direct neurite-mast cell communication in vitro occurs via the neuropeptide substance P

    R Suzuki;T Furuno;D M McKay;D Wolvers

  • Epithelia under metabolic stress perceive commensal bacteria as a threat

    Aisha Nazli;Ping-Chang Yang;Jennifer Jury;Kathryn Howe

  • Cytokine regulation of epithelial permeability and ion transport

    D M McKAY;A W Baird

  • The interaction between mast cells and nerves in the gastrointestinal tract

    Derek M. McKay;John Bienenstock

  • Neutralizing Anti-IL-10 Antibody Blocks the Protective Effect of Tapeworm Infection in a Murine Model of Chemically Induced Colitis

    Meaghan M. Hunter;Arthur Wang;Christina L. Hirota;Derek M. McKay

  • Integrative immunophysiology in the intestinal mucosa

    M. H. Perdue;D. M. McKay

  • Chronic Psychological Stress in Rats Induces Intestinal Sensitization to Luminal Antigens

    Ping-Chang Yang;Jennifer Jury;Johan D. Söderholm;Philip M. Sherman

  • Infection of T84 cells with enteropathogenic Escherichia coli alters barrier and transport functions

    D. J. Philpott;D. M. McKay;P. M. Sherman;M. H. Perdue

  • Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor α

    Johan D Söderholm;C Streutker;P-C Yang;C Paterson

  • Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NFκB-independent pathway

    Mahmood Akhtar;James L. Watson;Aisha Nazli;Derek M. McKay

  • Dextran sulfate sodium-induced colonic histopathology, but not altered epithelial ion transport, is reduced by inhibition of phosphodiesterase activity.

    Natalia Diaz-Granados;Kathryn Howe;Jun Lu;Derek M. McKay

  • Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement.

    Peter J.M. Ceponis;Fernando Botelho;Carl D. Richards;Derek M. McKay

  • Signal Transduction Pathways Involved in Enterohemorrhagic Escherichia coli-Induced Alterations in T84 Epithelial Permeability

    Dana J. Philpott;Derek M. McKay;Walter Mak;Mary H. Perdue

Frequent Co-Authors

Philip M. Sherman
Philip M. Sherman University of Toronto
Keith A. Sharkey
Keith A. Sharkey University of Calgary
Ping-Chang Yang
Ping-Chang Yang Shenzhen University
John Bienenstock
John Bienenstock McMaster University
Carl D. Richards
Carl D. Richards McMaster University
Cory M. Hogaboam
Cory M. Hogaboam Cedars-Sinai Medical Center
Jack Gauldie
Jack Gauldie McMaster University
Paul L. Beck
Paul L. Beck University of Calgary
Quentin J. Pittman
Quentin J. Pittman University of Calgary
Bruce A. Vallance
Bruce A. Vallance University of British Columbia

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