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Biology and Biochemistry

D-Index
44
Citations
7847
World Ranking
19271
National Ranking
7878

Overview

Brian E. Wadzinski is affiliated with Vanderbilt University in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. The primary focus of their work spans several subfields, including molecular biology, infectious diseases, cell biology, physiology, and radiology, nuclear medicine, and imaging.

Their research addresses multiple scientific topics, notably:

  • Alzheimer's disease research and treatments
  • SARS-CoV-2 and COVID-19 research
  • Monoclonal and polyclonal antibodies research
  • Bacteriophages and microbial interactions
  • Clostridium difficile and Clostridium perfringens research
  • Microtubule and mitosis dynamics
  • Viral gastroenteritis research and epidemiology

Wadzinski's publications have appeared in a range of scientific journals. The venues where they have published most frequently include:

  • PLoS Pathogens
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Alzheimer's & Dementia
  • Pharmaceuticals

Significant recent papers authored or coauthored by Wadzinski include:

  • "Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer's Disease" (2022), published in Pharmaceuticals
  • "PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation" (2020), published in Cell Reports
  • "Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19" (2023), published in Journal of Virology
  • "A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation" (2022), published in Journal of Biological Chemistry
  • "Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo" (2023), published in PLoS Pathogens

Their collaborations have included frequent co-authorship with several researchers:

  • Benjamin W. Spiller (16 coauthored publications)
  • Justin R. Haynes (6 coauthored publications)
  • Joanne A. Matsubara (6 coauthored publications)
  • Wellington Pham (6 coauthored publications)
  • Printha Wijesinghe (5 coauthored publications)

Best Publications

  • Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.

    Tsutomu Kabashima;Takumi Kawaguchi;Takumi Kawaguchi;Brian E. Wadzinski;Kosaku Uyeda

  • Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.

    B E Wadzinski;W H Wheat;S Jaspers;L F Peruski

  • Differential inactivation of postsynaptic density-associated and soluble Ca2+/calmodulin-dependent protein kinase II by protein phosphatases 1 and 2A.

    Stefan Strack;Mary Ann Barban;Brian E. Wadzinski;Roger J. Colbran

  • A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.

    Ryan S. Westphal;Kristin A. Anderson;Kristin A. Anderson;Anthony R. Means;Anthony R. Means;Brian E. Wadzinski;Brian E. Wadzinski

  • Insulin Dysfunction Induces In Vivo Tau Hyperphosphorylation through Distinct Mechanisms

    Emmanuel Planel;Yoshitaka Tatebayashi;Tomohiro Miyasaka;Li Liu

  • Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4

    Xiaohong Zhang;Yukiyasu Ozawa;Heehyoung Lee;Yu-Der Wen

  • Cocaine and Antidepressant-Sensitive Biogenic Amine Transporters Exist in Regulated Complexes with Protein Phosphatase 2A

    Andrea L. Bauman;Subbu Apparsundaram;Sammanda Ramamoorthy;Brian E. Wadzinski

  • Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A

    Westphal Rs;Coffee Rl;Marotta A;Pelech Sl

  • METHYLATED C-TERMINAL LEUCINE RESIDUE OF PP2A CATALYTIC SUBUNIT IS IMPORTANT FOR BINDING OF REGULATORY BALPHA SUBUNIT

    Jeffrey C. Bryant;Ryan S. Westphal;Brian E. Wadzinski

  • Targeting Protein Serine/Threonine Phosphatases for Drug Development

    Jamie L. McConnell;Brian E. Wadzinski

  • Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits.

    Stefan Strack;Julie A. Zaucha;Ford F. Ebner;Roger J. Colbran

  • Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.

    Chi Wu Chiang;Gregory Harris;Gregory Harris;Gregory Harris;Cindy Ellig;Cindy Ellig;Cindy Ellig;Shane C. Masters;Shane C. Masters;Shane C. Masters

  • O-GlcNAc Transferase Is in a Functional Complex with Protein Phosphatase 1 Catalytic Subunits

    Lance Wells;Lisa K. Kreppel;Frank I. Comer;Brian E. Wadzinski

  • Protein Phosphatase 2A Interacts with and Directly Dephosphorylates RelA

    Jinming Yang;Guo-Huang Fan;Brian E. Wadzinski;Hiroaki Sakurai

  • Death, Cardiac Dysfunction, and Arrhythmias Are Increased by Calmodulin Kinase II in Calcineurin Cardiomyopathy

    Michelle S.C. Khoo;Jingdong Li;Jingdong Li;Madhu V. Singh;Yingbo Yang

  • Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt.

    Michael J. Van Kanegan;Deanna G. Adams;Brian E. Wadzinski;Stefan Strack

  • Developmental regulation of the distribution of rat brain insulin-insensitive (Glut 1) glucose transporter.

    S. Devaskar;D. S. Zahm;L. Holtzclaw;K. Chundu

  • Brain Actin-associated Protein Phosphatase 1 Holoenzymes Containing Spinophilin, Neurabin, and Selected Catalytic Subunit Isoforms

    Leigh B. MacMillan;Martha A. Bass;Nikki Cheng;Eric F. Howard

  • Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.

    Deanna G. Adams;R. Lane Coffee;Hong Zhang;Steven Pelech

  • Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments.

    Stefan Strack;Ryan S Westphal;Roger J Colbran;Ford F Ebner

Frequent Co-Authors

Stefan Strack
Stefan Strack University of Iowa
Roger J. Colbran
Roger J. Colbran Vanderbilt University
Arnold E. Ruoho
Arnold E. Ruoho University of Wisconsin–Madison
Ford F. Ebner
Ford F. Ebner Vanderbilt University
Malek Kamoun
Malek Kamoun University of Pennsylvania
Shirish Shenolikar
Shirish Shenolikar Duke University
Michael L. Goldberg
Michael L. Goldberg Cornell University
David Shalloway
David Shalloway Cornell University
Gary L. Johnson
Gary L. Johnson University of North Carolina at Chapel Hill
Marc C. Mumby
Marc C. Mumby The University of Texas Southwestern Medical Center

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