World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
11651
World Ranking
15540
National Ranking
6482

Overview

Frances M. Sladek is affiliated with the University of California, Riverside in the United States. Their research spans various domains within medicine and biochemistry, genetics, and molecular biology. The scientist has contributed extensively to studies involving liver disease diagnosis and treatment, diet and metabolism, gut microbiota and health, pancreatic function and diabetes, as well as cancer-related topics linking metabolism and hypoxia.

The main fields of study associated with their work include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, more specific subfields addressed in their publications are:

  • Molecular Biology
  • Epidemiology
  • Physiology
  • Surgery
  • Cancer Research

The key research topics covered by Frances M. Sladek are:

  • Liver Disease Diagnosis and Treatment
  • Diet and metabolism studies
  • Gut microbiota and health
  • Pancreatic function and diabetes
  • Diet, Metabolism, and Disease
  • Metabolism, Diabetes, and Cancer
  • Cancer, Hypoxia, and Metabolism

Frances M. Sladek has coauthored numerous papers with frequent collaborators including Poonamjot Deol, Sarah H. Radi, Jonathan Deans, Paul Ruegger, and James Borneman.

They have published multiple articles in notable venues, with the most frequent publication outlets being:

  • Frontiers in Endocrinology
  • IUPHAR/BPS Guide to Pharmacology CITE
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Letters
  • Gut Microbes

Selected recent papers by Frances M. Sladek include:

  • "Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation," 2020, Cancer Letters
  • "Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice," 2023, Gut Microbes
  • "Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestine," 2023, Frontiers in Endocrinology
  • "Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice," 2020, Endocrinology
  • "HNF4α isoforms: the fraternal twin master regulators of liver function," 2023, Frontiers in Endocrinology

Best Publications

  • Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

    F M Sladek;W M Zhong;E Lai;J E Darnell

  • A unified nomenclature system for the nuclear receptor superfamily

    J. Auwerx;E. Baulieu;M. Beato;M. Becker-Andre

  • A transcriptional hierarchy involved in mammalian cell-type specification.

    Calvin J. Kuo;Pamela B. Conley;Lei Chen;Frances M. Sladek

  • Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters.

    Chuhu Yang;Eugene Bolotin;Tao Jiang;Frances M. Sladek

  • Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.

    M Mietus-Snyder;FM Sladek;GS Ginsburg;CF Kuo

  • Direct G Protein Modulation of Cav2 Calcium Channels

    H. William Tedford;Gerald W. Zamponi

  • Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

    Michele A. Battle;Genevieve Konopka;Fereshteh Parviz;Alexandra Lerch Gaggl

  • The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids.

    Robert K. Hall;Frances M. Sladek;Daryl K. Granner

  • International Union of Pharmacology. LXVI. Orphan Nuclear Receptors

    Gérard Benoit;Austin Cooney;Vincent Giguere;Holly Ingraham

  • Exclusive Homodimerization of the Orphan Receptor Hepatocyte Nuclear Factor 4 Defines a New Subclass of Nuclear Receptors

    Guoqiang Jiang;Luviminda Nepomuceno;K. Hopkins;F. M. Sladek

  • Identification of an endogenous ligand bound to a native orphan nuclear receptor.

    Xiaohui Yuan;Tuong Chi Ta;Min Lin;Jane R. Evans

  • AMP-Activated Protein Kinase Is Involved in Endothelial NO Synthase Activation in Response to Shear Stress

    Yingjia Zhang;Tzong Shyuan Lee;Erik M. Kolb;Kai Sun

  • The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription.

    Kleanthis G. Xanthopoulos;Vincent R. Prezioso;William S. Chen;Frances M. Sladek

  • Hepatocyte Nuclear Factor 4α Is Essential for Embryonic Development of the Mouse Colon

    Wendy D. Garrison;Michele A. Battle;Chuhu Yang;Klaus H. Kaestner

  • MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300

    Qi Jing Li;Shen Hsi Yang;Yutaka Maeda;Frances M. Sladek

  • Hepatocyte Nuclear Factor-4α Is Essential for Glucose-stimulated Insulin Secretion by Pancreatic β-Cells

    Atsuko Miura;Kazuya Yamagata;Masafumi Kakei;Hiroyasu Hatakeyama

  • Integrated approach for the identification of human hepatocyte nuclear factor 4α target genes using protein binding microarrays

    Eugene Bolotin;Hailing Liao;Tuong Chi Ta;Chuhu Yang

  • What are nuclear receptor ligands

    Frances M. Sladek

  • Hepatocyte Nuclear Factor 4α

    Frances M. Sladek;Shawn D. Seidel

  • Modulation of Transcriptional Activation and Coactivator Interaction by a Splicing Variation in the F Domain of Nuclear Receptor Hepatocyte Nuclear Factor 4α1

    Frances M. Sladek;Michael D. Ruse;Luviminda Nepomuceno;Shih-Ming Huang

Frequent Co-Authors

Peggy J. Farnham
Peggy J. Farnham University of Southern California
Sylvie Mader
Sylvie Mader University of Montreal
Kathleen J. Millen
Kathleen J. Millen Seattle Children's Hospital
Robert F. Hevner
Robert F. Hevner University of California, San Diego
Paola Bovolenta
Paola Bovolenta Spanish National Research Council
Bruce E. Torbett
Bruce E. Torbett Seattle Children's Hospital
Elizabeth M. Simpson
Elizabeth M. Simpson University of British Columbia
Wyeth W. Wasserman
Wyeth W. Wasserman University of British Columbia
Reiner A. Veitia
Reiner A. Veitia Université Paris Cité
Alison H. Banham
Alison H. Banham University of Oxford

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