His primary scientific interests are in Cell biology, Transcription factor, Internal medicine, Endocrinology and Hepatocyte Nuclear Factor 6. His work carried out in the field of Cell biology brings together such families of science as Bile duct, Intrahepatic bile ducts and Endoderm, Cellular differentiation. The Cellular differentiation study combines topics in areas such as Molecular biology, Liver cell, Hepatocyte nuclear factors and Regulation of gene expression.
His studies deal with areas such as Gene silencing, Morphogenesis and Insulin as well as Transcription factor. In his research, Hepatocyte and Liver regeneration is intimately related to Progenitor cell, which falls under the overarching field of Internal medicine. His work in Hepatocyte Nuclear Factor 6 addresses subjects such as Onecut Transcription Factors, which are connected to disciplines such as Transcription.
Frédéric P. Lemaigre focuses on Cell biology, Transcription factor, Internal medicine, Endocrinology and Molecular biology. His Cell biology research is multidisciplinary, incorporating perspectives in Endoderm, Cellular differentiation, Hepatocyte, Morphogenesis and Bile duct. Frédéric P. Lemaigre does research in Transcription factor, focusing on Hepatocyte Nuclear Factor 6 specifically.
His work on TGF beta signaling pathway as part of general Internal medicine research is frequently linked to Genetic variability, bridging the gap between disciplines. His Endocrinology study combines topics from a wide range of disciplines, such as Progenitor cell and Embryonic stem cell. The concepts of his Molecular biology study are interwoven with issues in Glucocorticoid receptor, Glucocorticoid, Promoter, Binding site and Gene isoform.
His primary areas of study are Cancer research, KRAS, Carcinogenesis, Transcriptome and Cell. His research in Cancer research intersects with topics in Inflammation, Tissue homeostasis, Antibody and In situ hybridization. His KRAS study combines topics in areas such as Intraductal papillary mucinous neoplasm, Pancreas, Pancreatic cancer and Effector.
The various areas that Frédéric P. Lemaigre examines in his Carcinogenesis study include Tumor progression, Signal transduction, Intrahepatic Cholangiocarcinoma and Transcription factor. Frédéric P. Lemaigre mostly deals with Hepatocyte nuclear factors in his studies of Transcription factor. His study in Cell is interdisciplinary in nature, drawing from both Beta-catenin, SMARCA4, microRNA, Gene and Gene regulatory network.
The scientist’s investigation covers issues in Bile duct, Cell biology, Pancreatic cancer, Cancer research and Morphogenesis. Frédéric P. Lemaigre has researched Bile duct in several fields, including Liver injury and Genetically modified mouse. The various areas that Frédéric P. Lemaigre examines in his Cell biology study include Hepatocyte and Cholangiocyte.
His Hepatocyte research includes themes of Regulator, Internal medicine and Hepatocyte nuclear factors. His Cholangiocyte research includes elements of Progenitor cell, Transcription factor, Gene expression and Cellular differentiation. While the research belongs to areas of Morphogenesis, he spends his time largely on the problem of Biliary tract, intersecting his research to questions surrounding Regenerative medicine and Bioinformatics.
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Organogenesis and development of the liver.
Karim Si-Tayeb;Frédéric P. Lemaigre;Stephen A. Duncan;Stephen A. Duncan.
Developmental Cell (2010)
Notch signaling controls liver development by regulating biliary differentiation
Yiwei Zong;Archana Panikkar;Jie Xu;Aline Antoniou.
The onecut transcription factor HNF6 is required for normal development of the biliary tract
Frédéric Clotman;Vincent J. Lannoy;Michael Reber;Silvia Cereghini.
MicroRNA-9 Controls the Expression of Granuphilin/Slp4 and the Secretory Response of Insulin-producing Cells
Valérie Plaisance;Amar Abderrahmani;Amar Abderrahmani;Véronique Perret-Menoud;Patrick Jacquemin.
Journal of Biological Chemistry (2006)
Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.
Patrick Jacquemin;Serge M. Durviaux;Jan Jensen;Catherine Godfraind.
Molecular and Cellular Biology (2000)
Control of liver cell fate decision by a gradient of TGFβ signaling modulated by Onecut transcription factors
Frédéric Clotman;Patrick Jacquemin;Nicolas Plumb-Rudewiez;Christophe E. Pierreux.
Genes & Development (2005)
Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9
Aline Antoniou;Peggy Raynaud;Sabine Cordi;Yiwei Zong.
Liver development update: new embryo models, cell lineage control, and morphogenesis
Frederic Lemaigre;Kenneth S Zaret.
Current Opinion in Genetics & Development (2004)
Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice
Regina Español–Suñer;Rodolphe Carpentier;Noémi Van Hul;Vanessa Legry.
Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies.
Frédéric P. Lemaigre.
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