What is he best known for?
The fields of study he is best known for:
- Gene
- Transcription factor
- DNA
His primary scientific interests are in Cell biology, Transcription factor, Internal medicine, Endocrinology and Hepatocyte Nuclear Factor 6.
His work carried out in the field of Cell biology brings together such families of science as Bile duct, Intrahepatic bile ducts and Endoderm, Cellular differentiation.
The Cellular differentiation study combines topics in areas such as Molecular biology, Liver cell, Hepatocyte nuclear factors and Regulation of gene expression.
His studies deal with areas such as Gene silencing, Morphogenesis and Insulin as well as Transcription factor.
In his research, Hepatocyte and Liver regeneration is intimately related to Progenitor cell, which falls under the overarching field of Internal medicine.
His work in Hepatocyte Nuclear Factor 6 addresses subjects such as Onecut Transcription Factors, which are connected to disciplines such as Transcription.
His most cited work include:
- Organogenesis and development of the liver. (486 citations)
- Notch signaling controls liver development by regulating biliary differentiation (313 citations)
- Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. (290 citations)
What are the main themes of his work throughout his whole career to date?
Frédéric P. Lemaigre focuses on Cell biology, Transcription factor, Internal medicine, Endocrinology and Molecular biology.
His Cell biology research is multidisciplinary, incorporating perspectives in Endoderm, Cellular differentiation, Hepatocyte, Morphogenesis and Bile duct.
Frédéric P. Lemaigre does research in Transcription factor, focusing on Hepatocyte Nuclear Factor 6 specifically.
His work on TGF beta signaling pathway as part of general Internal medicine research is frequently linked to Genetic variability, bridging the gap between disciplines.
His Endocrinology study combines topics from a wide range of disciplines, such as Progenitor cell and Embryonic stem cell.
The concepts of his Molecular biology study are interwoven with issues in Glucocorticoid receptor, Glucocorticoid, Promoter, Binding site and Gene isoform.
He most often published in these fields:
- Cell biology (39.63%)
- Transcription factor (35.98%)
- Internal medicine (30.49%)
What were the highlights of his more recent work (between 2017-2021)?
- Cancer research (11.59%)
- KRAS (4.27%)
- Carcinogenesis (4.27%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Cancer research, KRAS, Carcinogenesis, Transcriptome and Cell.
His research in Cancer research intersects with topics in Inflammation, Tissue homeostasis, Antibody and In situ hybridization.
His KRAS study combines topics in areas such as Intraductal papillary mucinous neoplasm, Pancreas, Pancreatic cancer and Effector.
The various areas that Frédéric P. Lemaigre examines in his Carcinogenesis study include Tumor progression, Signal transduction, Intrahepatic Cholangiocarcinoma and Transcription factor.
Frédéric P. Lemaigre mostly deals with Hepatocyte nuclear factors in his studies of Transcription factor.
His study in Cell is interdisciplinary in nature, drawing from both Beta-catenin, SMARCA4, microRNA, Gene and Gene regulatory network.
Between 2017 and 2021, his most popular works were:
- Development of the liver: Insights into organ and tissue morphogenesis (64 citations)
- Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells. (10 citations)
- Development of the Intrahepatic and Extrahepatic Biliary Tract: A Framework for Understanding Congenital Diseases. (9 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Transcription factor
- DNA
The scientist’s investigation covers issues in Bile duct, Cell biology, Pancreatic cancer, Cancer research and Morphogenesis.
Frédéric P. Lemaigre has researched Bile duct in several fields, including Liver injury and Genetically modified mouse.
The various areas that Frédéric P. Lemaigre examines in his Cell biology study include Hepatocyte and Cholangiocyte.
His Hepatocyte research includes themes of Regulator, Internal medicine and Hepatocyte nuclear factors.
His Cholangiocyte research includes elements of Progenitor cell, Transcription factor, Gene expression and Cellular differentiation.
While the research belongs to areas of Morphogenesis, he spends his time largely on the problem of Biliary tract, intersecting his research to questions surrounding Regenerative medicine and Bioinformatics.
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