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Biology and Biochemistry

D-Index
62
Citations
13273
World Ranking
10837
National Ranking
196

Overview

Frédéric P. Lemaigre is affiliated with the Université Catholique de Louvain in Belgium, with a research focus predominantly situated within the field of Medicine. Their work spans multiple subfields including Surgery, Hepatology, Oncology, Molecular Biology, and Pulmonary and Respiratory Medicine.

Their scientific contributions concentrate on several main topics, reflecting a comprehensive engagement with liver and pancreatic health and disease. These include:

  • Liver physiology and pathology
  • Pancreatic and Hepatic Oncology Research
  • Pancreatic function and diabetes
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Pediatric Hepatobiliary Diseases and Treatments
  • Pancreatitis Pathology and Treatment
  • Liver Disease Diagnosis and Treatment

Recent publications authored by or involving Frédéric P. Lemaigre illustrate their involvement with significant research questions related to liver and pancreatic health. These publications are:

  • Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids, 2021, Cell stem cell
  • Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis, 2020, Gastroenterology
  • Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation, 2021, Science Signaling
  • A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin-4 in Tumor Progression, 2021, Hepatology
  • Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells, 2021, Cancer Research

The scientist frequently publishes in venues such as Cellular and Molecular Gastroenterology and Hepatology, PLoS Computational Biology, bioRxiv (Cold Spring Harbor Laboratory), Journal of Hepatology, and Cell stem cell, indicating a focus on journals related to gastroenterology, hepatology, and cellular biology.

Collaboration is an evident aspect of their work. Frequent co-authors include:

  • Patrick Jacquemin
  • Sabine Cordi
  • Axelle Loriot
  • Mohamad Assi
  • Younès Achouri

Best Publications

  • Organogenesis and development of the liver.

    Karim Si-Tayeb;Frédéric P. Lemaigre;Stephen A. Duncan;Stephen A. Duncan

  • Notch signaling controls liver development by regulating biliary differentiation

    Yiwei Zong;Archana Panikkar;Jie Xu;Aline Antoniou

  • The onecut transcription factor HNF6 is required for normal development of the biliary tract

    Frédéric Clotman;Vincent J. Lannoy;Michael Reber;Silvia Cereghini

  • MicroRNA-9 Controls the Expression of Granuphilin/Slp4 and the Secretory Response of Insulin-producing Cells

    Valérie Plaisance;Amar Abderrahmani;Amar Abderrahmani;Véronique Perret-Menoud;Patrick Jacquemin

  • Control of liver cell fate decision by a gradient of TGFβ signaling modulated by Onecut transcription factors

    Frédéric Clotman;Patrick Jacquemin;Nicolas Plumb-Rudewiez;Christophe E. Pierreux

  • Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9

    Aline Antoniou;Peggy Raynaud;Sabine Cordi;Yiwei Zong

  • Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.

    Patrick Jacquemin;Serge M. Durviaux;Jan Jensen;Catherine Godfraind

  • Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice

    Regina Español–Suñer;Rodolphe Carpentier;Noémi Van Hul;Vanessa Legry

  • Liver development update: new embryo models, cell lineage control, and morphogenesis

    Frederic Lemaigre;Kenneth S Zaret

  • Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies.

    Frédéric P. Lemaigre

  • Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells.

    Rodolphe Carpentier;Regina Español Suñer;Noémi van Hul;Janel L. Kopp

  • The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.

    Patrick Jacquemin;Frédéric P Lemaigre;Guy G Rousseau

  • Development of the biliary tract.

    Frédéric P. Lemaigre

  • Development of the liver: Insights into organ and tissue morphogenesis

    Elke A. Ober;Frédéric P. Lemaigre

  • A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation

    Ilaria Laudadio;Isabelle Manfroid;Younes Achouri;Dominic Schmidt

  • Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment

    Xueru Mu;Regina Español-Suñer;Ingmar Mederacke;Silvia Affò

  • Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

    Ary Marsee;Floris J M Roos;Monique M A Verstegen

  • Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas

    Miguel A. Maestro;Sylvia F. Boj;Reini F. Luco;Christophe E. Pierreux

  • HEPATOCYTE NUCLEAR FACTOR 6, A TRANSCRIPTION FACTOR THAT CONTAINS A NOVEL TYPE OF HOMEODOMAIN AND A SINGLE CUT DOMAIN

    Frederic P. Lemaigre;Serge M. Durviaux;Oanh Truong;Vincent J. Lannoy

  • HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors.

    Claire Landry;Frédéric Clotman;Takeshi Hioki;Hiroaki Oda

Frequent Co-Authors

Guy G. Rousseau
Guy G. Rousseau Université Catholique de Louvain
Pierre J. Courtoy
Pierre J. Courtoy Université Catholique de Louvain
Paul Gissen
Paul Gissen University College London
Hans Eiberg
Hans Eiberg University of Copenhagen
Tania Roskams
Tania Roskams KU Leuven
Ben Z. Stanger
Ben Z. Stanger University of Pennsylvania
Sean M. Grimmond
Sean M. Grimmond University of Melbourne
Nicola Waddell
Nicola Waddell QIMR Berghofer Medical Research Institute
Duncan T. Odom
Duncan T. Odom University of Cambridge
Marina Pajic
Marina Pajic Garvan Institute of Medical Research

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