D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 73 Citations 14,658 100 World Ranking 2578 National Ranking 1360

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Transcription factor

Robert H. Costa spends much of his time researching Molecular biology, Transcription factor, Hepatocyte nuclear factors, FOXM1 and Cancer research. His studies in Molecular biology integrate themes in fields like Mitosis, Liver regeneration, Enhancer, DNA-binding domain and FOXA2. His Transcription factor study combines topics in areas such as Cell culture, Transcription and Cell biology.

His work in Cell biology addresses issues such as E-box, which are connected to fields such as Lung morphogenesis. As part of the same scientific family, Robert H. Costa usually focuses on Hepatocyte nuclear factors, concentrating on Hepatocyte Nuclear Factor 3-alpha and intersecting with Homeotic gene, Hepatocyte Nuclear Factor 3-Gamma and DNA binding site. His Cancer research study combines topics from a wide range of disciplines, such as Carcinogenesis, Cancer, Cyclin A2 and Cyclin A.

His most cited work include:

  • Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase (459 citations)
  • Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. (442 citations)
  • Transcription factors in liver development, differentiation, and regeneration. (343 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Molecular biology, Transcription factor, Cell biology, Hepatocyte nuclear factors and Cancer research. The study incorporates disciplines such as Enhancer, Cell cycle, Gene, DNA-binding domain and FOXA2 in addition to Molecular biology. He specializes in Transcription factor, namely FOXM1.

His study in Cell biology is interdisciplinary in nature, drawing from both Endocrinology, Endoderm, DNA-binding protein, Internal medicine and Morphogenesis. His research in Hepatocyte nuclear factors intersects with topics in Hepatocyte Nuclear Factor 3-alpha, Hepatocyte nuclear factor 4, Winged Helix and Binding site. He works mostly in the field of Cancer research, limiting it down to topics relating to Transgene and, in certain cases, Ectopic expression.

He most often published in these fields:

  • Molecular biology (52.80%)
  • Transcription factor (42.40%)
  • Cell biology (29.60%)

What were the highlights of his more recent work (between 2007-2013)?

  • Transcription factor (42.40%)
  • Cancer research (16.80%)
  • FOXM1 (15.20%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Transcription factor, Cancer research, FOXM1, Cell culture and Molecular biology. His Transcription factor research includes themes of Carcinogenesis, Malignant transformation, Gene expression and Gene knockdown. His studies deal with areas such as Embryonic stem cell, Progenitor cell, Metaplasia and Pancreatic duct, Pancreas as well as Cancer research.

His FOXM1 research incorporates elements of Stathmin and Cell biology. His Small interfering RNA study, which is part of a larger body of work in Cell culture, is frequently linked to Population, bridging the gap between disciplines. His biological study spans a wide range of topics, including Cell cycle, Mitosis, Phosphorylation and Forkhead Transcription Factors.

Between 2007 and 2013, his most popular works were:

  • FoxM1, a critical regulator of oxidative stress during oncogenesis (160 citations)
  • Deregulation of FoxM1b leads to tumour metastasis. (106 citations)
  • FoxM1 Regulates Transcription of JNK1 to Promote the G1/S Transition and Tumor Cell Invasiveness (104 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Transcription factor

His primary scientific interests are in Transcription factor, FOXM1, Cancer research, Malignant transformation and Cell cycle. In most of his Transcription factor studies, his work intersects topics such as Carcinoma. His work carried out in the field of Carcinoma brings together such families of science as Epithelial–mesenchymal transition, Metastasis and Stathmin.

The various areas that Robert H. Costa examines in his Malignant transformation study include Regulator, Apoptosis, Reactive oxygen species and Carcinogenesis. Robert H. Costa has researched Cell cycle in several fields, including Cell culture, Transfection, Gene knockdown and Cell biology. The study of Cell biology is intertwined with the study of Regulation of gene expression in a number of ways.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase

I-Ching Wang;Yi-Ju Chen;Douglas Hughes;Vladimir Petrovic.
Molecular and Cellular Biology (2005)

632 Citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

R. H. Costa;Dennis R. Grayson;J. E. Darnell.
Molecular and Cellular Biology (1989)

603 Citations

Transcription factors in liver development, differentiation, and regeneration.

Robert H. Costa;Vladimir V. Kalinichenko;Ai Xuan L Holterman;Xinhe Wang.
Hepatology (2003)

527 Citations

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.

D G Overdier;A Porcella;R H Costa.
Molecular and Cellular Biology (1994)

508 Citations

Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor

Vladimir V. Kalinichenko;Michael L. Major;Xinhe Wang;Vladimir Petrovic.
Genes & Development (2004)

438 Citations

Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.

H Ye;T F Kelly;U Samadani;L Lim.
Molecular and Cellular Biology (1997)

391 Citations

The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer.

Il-Man Kim;Timothy Ackerson;Sneha Ramakrishna;Maria Tretiakova.
Cancer Research (2006)

364 Citations

Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice.

Tanya V. Kalin;I-Ching Wang;Timothy J. Ackerson;Michael L. Major.
Cancer Research (2006)

356 Citations

The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration

Xinhe Wang;Hiroaki Kiyokawa;Margaret B. Dennewitz;Robert H. Costa.
Proceedings of the National Academy of Sciences of the United States of America (2002)

336 Citations

Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.

Michael L. Major;Rita Lepe;Robert H. Costa.
Molecular and Cellular Biology (2004)

315 Citations

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