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Elizabeth M. Simpson

Elizabeth M. Simpson

D-Index & Metrics

Genetics

D-Index
59
Citations
17071
World Ranking
3212
National Ranking
119

Overview

Elizabeth M. Simpson is affiliated with the University of British Columbia in Canada and specializes in the field of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology and Genetics. Their research spans several related subfields, including Radiology, Nuclear Medicine and Imaging, Cellular and Molecular Neuroscience, and Ophthalmology.

Their documented work covers a range of topics, notably:

  • CRISPR and Genetic Engineering
  • Retinal Development and Disorders
  • Virus-based gene therapy research
  • Genomics and Chromatin Dynamics
  • RNA Interference and Gene Delivery
  • Advanced biosensing and bioanalysis techniques
  • Genetics, Aging, and Longevity in Model Organisms

Their recent scholarly publications include the following papers:

  • LNP-mediated delivery of CRISPR RNP for wide-spread in vivo genome editing in mouse cornea, 2022, Journal of Controlled Release
  • Intracerebroventricular Administration of AAV9-PHP.B SYN1-EmGFP Induces Widespread Transgene Expression in the Mouse and Monkey Central Nervous System, 2021, Human Gene Therapy
  • A novel mouse model for pyridoxine-dependent epilepsy due to antiquitin deficiency, 2020, Human Molecular Genetics
  • Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells, 2021, Gene Therapy
  • Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia, 2020, Molecular Therapy - Methods & Clinical Development

Elizabeth M. Simpson frequently publishes in the following venues:

  • Gene Therapy
  • Investigative Ophthalmology & Visual Science
  • Human Gene Therapy
  • Human Molecular Genetics
  • Molecular Therapy - Methods & Clinical Development

The scientist has collaborated multiple times with a set of coauthors, including:

  • Andrea J. Korecki
  • Tess C. Lengyell
  • Blair R. Leavitt
  • Wyeth W. Wasserman
  • Siu Ling Lam

Best Publications

  • Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

    Catherine D. Van Raamsdonk;Vladimir Bezrookove;Gary G.R. Green;Jürgen Bauer

  • Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

    Sven Enerbäck;Anders Jacobsson;Elizabeth M. Simpson;Carmen Guerra

  • The sex-determining region of the human Y chromosome encodes a finger protein

    David C. Page;Rebecca Mosher;Elizabeth M. Simpson;Elizabeth M.C. Fisher

  • Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

    Elizabeth J. Slow;Jeremy van Raamsdonk;Daniel Rogers;Sarah H. Coleman

  • Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

    Elizabeth M. Simpson;Carol C. Linder;Evelyn E. Sargent;Muriel T. Davisson

  • B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

    Frank Borriello;Michael P Sethna;Scott D Boyd;A.Nicola Schweitzer

  • Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain.

    Torben Lund;Lorraine O'Reilly;Patricia Hutchings;Osami Kanagawa

  • Mutant mice and neuroscience: Recommendations concerning genetic background

    Alcino J. Silva;Elizabeth M. Simpson;Joseph S. Takahashi;Hans Peter Lipp

  • Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes

    P. J. Dyson;A. M. Knight;S. Fairchild;E. Simpson

  • The mammalian gene function resource: the international knockout mouse consortium

    Allan Bradley;Konstantinos Anastassiadis;Abdelkader Ayadi;James F. Battey

  • The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events.

    Elisabeth H. Weiss;Elisabeth H. Weiss;Andrew L. Mellor;Andrew L. Mellor;L. Golden;L. Golden;K. Fahrner

  • Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages.

    Patricia Hutchings;Hugh Rosen;Lorraine O'Reilly;Elizabeth Simpson

  • Responsiveness to HY Antigen Ir Gene Complementation and Target Cell Specificity

    Elizabeth Simpson;Robert D. Gordon

  • Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen.

    Clio Mamalaki;James Elliott;Trisha Norton;Nicholas Yannoutsos

  • A glycophospholipid anchor is required for Qa-2 mediated T cell activation.

    Peter J. Robinson;Margaret Millrain;Jane Antoniou;Elizabeth Simpson

  • Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

    Clio Mamalaki;Trisha Norton;Yujiro Tanaka;Alain R. Townsend

  • Impaired fertility in mice deficient for the testicular germ-cell protease PC4.

    M Mbikay;H Tadros;N Ishida;C P Lerner

  • T-cell lines producing antigen-specific suppressor factor

    Sirkka Kontiainen;Elizabeth Simpson;Elaine Bohrer;P. C. L. Beverley

  • Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression.

    Lorraine A. O'reilly;Patricia R. Hutchings;Paul R. Crocker;Elizabeth Simpson

  • Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities.

    R. S. Devon;P. C. Orban;K. Gerrow;M. A. Barbieri

Frequent Co-Authors

Wyeth W. Wasserman
Wyeth W. Wasserman University of British Columbia
Robert A. Holt
Robert A. Holt BC Cancer Research Institute
Dan Goldowitz
Dan Goldowitz University of British Columbia
Steven J.M. Jones
Steven J.M. Jones University of British Columbia
Anne Cooke
Anne Cooke University of Cambridge
Lorraine A. O'Reilly
Lorraine A. O'Reilly Walter and Eliza Hall Institute of Medical Research
Pamela A. Hoodless
Pamela A. Hoodless University of British Columbia
Dimitris Kioussis
Dimitris Kioussis Medical Research Council
Alain Townsend
Alain Townsend University of Oxford

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