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Jan Nedergaard

Jan Nedergaard

D-Index & Metrics

Medicine

D-Index
98
Citations
42157
World Ranking
8830
National Ranking
177

Overview

Jan Nedergaard is affiliated with Stockholm University in Sweden and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans subfields including physiology, epidemiology, cardiology and cardiovascular medicine, molecular biology, and rehabilitation.

Their research primarily focuses on topics related to adipose tissue and metabolism, adipokines, inflammation and metabolic diseases, as well as cardiovascular disease and adiposity. Additional interests include exercise and physiological responses, diet and metabolism studies, muscle metabolism and nutrition, and mitochondrial function and pathology.

Notable recent publications by Jan Nedergaard include:

  • "Brown adipose tissue: can it keep us slim? A discussion of the evidence for and against the existence of diet-induced thermogenesis in mice and men," 2023, Philosophical Transactions of the Royal Society B Biological Sciences
  • "Diet-Induced Thermogenesis: Principles and Pitfalls," 2022, Methods in Molecular Biology

Other recent influential papers in related fields that align with their area of study include:

  • "Human brown adipose tissue: Classical brown rather than brite/beige?", 2020, Experimental Physiology
  • "Emerging debates and resolutions in brown adipose tissue research," 2024, Cell Metabolism
  • "A pyrexic effect of FGF21 independent of energy expenditure and UCP1," 2021, Molecular Metabolism

Jan Nedergaard has collaborated frequently with other researchers, including:

  • Barbara Cannon
  • Nataša Petrovič
  • Irina G. Shabalina
  • Erik Lindsund
  • Glauber Rudá Feitoza Braz

Their work has been published in several prominent venues, with multiple contributions to the American Journal of Physiology-Endocrinology and Metabolism, Biochimica et Biophysica Acta (BBA) - Bioenergetics, Molecular Metabolism, Methods in Molecular Biology, and Cell Metabolism.

Best Publications

  • Brown Adipose Tissue: Function and Physiological Significance

    Barbara Cannon;Jan Nedergaard

  • Unexpected evidence for active brown adipose tissue in adult humans

    Jan Nedergaard;Tore Bengtsson;Barbara Cannon

  • Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

    Natasa Petrovic;Tomas B. Walden;Irina G. Shabalina;James A. Timmons

  • UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

    Helena M. Feldmann;Valeria Golozoubova;Barbara Cannon;Jan Nedergaard

  • Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages

    James A. Timmons;James A. Timmons;James A. Timmons;Kristian Wennmalm;Ola Larsson;Tomas B. Walden;Tomas B. Walden

  • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

    Maria Cristina Zingaretti;Francesca Crosta;Alessandra Vitali;Mario Guerrieri

  • Nonshivering thermogenesis and its adequate measurement in metabolic studies

    Barbara Cannon;Jan Nedergaard

  • UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.

    Jan Nedergaard;Valeria Golozoubova;Anita Matthias;Abolfazl Asadi

  • UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

    Irina G. Shabalina;Natasa Petrovic;Jasper M.A. de Jong;Anastasia V. Kalinovich

  • Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

    Tomas B. Waldén;Ida R. Hansen;James A. Timmons;James A. Timmons;Barbara Cannon;Barbara Cannon

  • A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

    Naja Zenius Jespersen;Therese Juhlin Larsen;Lone Peijs;Søren Daugaard

  • Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold

    Valeria Golozoubova;Esa Hohtola;Anita Matthias;Anders Jacobsson

  • The browning of white adipose tissue: some burning issues.

    Jan Nedergaard;Barbara Cannon

  • The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

    Jan Nedergaard;Barbara Cannon

  • Genetic and functional characterization of clonally derived adult human brown adipocytes

    Kosaku Shinoda;Ineke H N Luijten;Yutaka Hasegawa;Haemin Hong

  • The biochemistry of an inefficient tissue: brown adipose tissue.

    B Cannon;J Nedergaard

  • Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis.

    Anita Matthias;K. B. E. Ohlson;J. M. Fredriksson;A. Jacobsson

  • Hypoxia-independent angiogenesis in adipose tissues during cold acclimation.

    Yuan Xue;Natasa Petrovic;Renhai Cao;Ola Larsson

  • Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

    Katrin Fischer;Henry H. Ruiz;Kevin Jhun;Brian Finan

  • A stringent validation of mouse adipose tissue identity markers

    Jasper M. A. de Jong;Ola Larsson;Barbara Cannon;Jan Nedergaard

Frequent Co-Authors

Barbara Cannon
Barbara Cannon Stockholm University
Nils-Göran Larsson
Nils-Göran Larsson Karolinska Institute
Saverio Cinti
Saverio Cinti Marche Polytechnic University
Peter Arner
Peter Arner Karolinska Institute
Vladimir P. Skulachev
Vladimir P. Skulachev Lomonosov Moscow State University
Kjell Hultenby
Kjell Hultenby Karolinska Institute
Mikael Rydén
Mikael Rydén Karolinska University Hospital
Lise Madsen
Lise Madsen University of Bergen
Susanne Mandrup
Susanne Mandrup University of Southern Denmark
Pere Puigserver
Pere Puigserver Harvard University

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