Peter J. O'Brien

Overview

Best Publications

• Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia

  J Fujii;K Otsu;F Zorzato;S de Leon

  2181
  Citations

• Molecular mechanisms of quinone cytotoxicity.

  O'Brien Pj

  1476
  Citations

• Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.

  Giuseppe Galati;Peter J O'Brien

  1395
  Citations

• Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.

  Peter J. O'Brien;Arno G. Siraki;Nandita Shangari

  787
  Citations

• High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.

  P. J. O’Brien;W. Irwin;D. Diaz;E. Howard-Cofield

  680
  Citations

• Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics.

  Giuseppe Galati;Omid Sabzevari;John X Wilson;Peter J O'Brien

  666
  Citations

• Flavonoid B-ring chemistry and antioxidant activity: fast reaction kinetics

  Ananth Sekher Pannala;Tom S. Chan;Peter J. O'Brien;Catherine A. Rice-Evans

  603
  Citations

• Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.

  Flore Depeint;W. Robert Bruce;Nandita Shangari;Rhea Mehta

  529
  Citations

• Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins

  Giuseppe Galati;Alison Lin;Amira M. Sultan;Peter J. O'Brien

  483
  Citations

• Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals:

  P J O'Brien;D E C Smith;T J Knechtel;M A Marchak

  359
  Citations

• A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+

  Jalal Pourahmad;Peter J O’Brien

  341
  Citations

• Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers.

  Majid Y Moridani;Jalal Pourahmad;Hoang Bui;Arno Siraki

  331
  Citations

• Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes.

  Jonathan W. Martin;Scott A. Mabury;Peter J. O’Brien

  317
  Citations

• Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics.

  G. Galati;S. Teng;M.Y. Moridani;T.S. Chan

  309
  Citations

• Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity.

  Peter James O’Brien

  305
  Citations

• Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1.

  Robert C. Cumming;Jeff Lightfoot;Kristin Beard;Hagop Youssoufian

  295
  Citations

• Molecular mechanisms of hydrogen sulfide toxicity.

  Don H Truong;Mohammad A Eghbal;Wayne Hindmarsh;Sheldon H Roth

  292
  Citations

• Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation.

  Giuseppe Galati;Majid Y. Moridani;Tom S. Chan;Peter J. O’Brien

  290
  Citations

• The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes.

  Shirley Teng;Kristin Beard;Jalal Pourahmad;Majid Moridani

  276
  Citations

• Mitochondrial function and toxicity: Role of B vitamins on the one-carbon transfer pathways

  Flore Depeint;W. Robert Bruce;Nandita Shangari;Rhea Mehta

  273
  Citations