José V. Castell

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Spain Leader Award

Overview

Best Publications

• Interleukin-6 and the acute phase response

  P C Heinrich;J V Castell;T Andus

  3842
  Citations

• Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

  José V. Castell;Maria J. Gómez-Lechón;Martina David;Tilo Andus

  1157
  Citations

• Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6.

  José V. Castell;Maria José Gómez-lechón;Martina David;Ricardo Fabra

  1002
  Citations

• Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes.

  José V. Castell;Maria J. Gómez-Lechón;Martina David;Toshio Hirano

  624
  Citations

• A human hepatocellular in vitro model to investigate steatosis.

  María José Gómez-Lechón;María Teresa Donato;Alicia Martínez-Romero;Nuria Jiménez

  590
  Citations

• Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells.

  C. Rodríguez-Antona;M. T. Donato;A. Boobis;R. J. Edwards

  458
  Citations

• Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat.

  José V. Castell;Thomas Geiger;Volker Gross;Tilo Andus

  409
  Citations

• Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells

  Raquel Taléns-Visconti;Ana Bonora;Ramiro Jover;Vicente Mirabet

  345
  Citations

• Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach

  José V. Castell;M. Teresa Donato;María José Gómez-Lechón

  312
  Citations

• Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways

  Roque Bort;Katherine Macé;Alan Boobis;Marı́a-José Gómez-Lechón

  308
  Citations

• Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

  M. J. Gomez-Lechon;M. T. Donato;J. V. Castell;R. Jover

  298
  Citations

• FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMES

  M. Teresa Donato;Nuria Jiménez;José V. Castell;M. José Gómez-Lechón

  292
  Citations

• Human hepatocytes as a tool for studying toxicity and drug metabolism.

  M. J. Gomez-Lechon;M. T. Donato;J. V. Castell;R. Jover

  282
  Citations

• Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

  Ramiro Jover;Roque Bort;María J. Gómez‐Lechón;José V. Castell

  277
  Citations

• Interleukin-6. The major regulator of acute-phase protein synthesis in man and rat.

  JOSé V. Castell;Tilo Andus;Dieter Kunz;Peter C. Heinrich

  269
  Citations

• Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

  Juan C. García-Cañaveras;M. Teresa Donato;José V. Castell;Agustín Lahoz

  264
  Citations

• Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.

  José V Castell;Ramiro Jover;Celia P Martínez-Jiménez;María José Gómez-Lechón

  261
  Citations

• Down-regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factors involved

  Ramiro Jover;Roque Bort;Ma. José Gómez-Lechón;Joseé V. Castell

  260
  Citations

• Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.

  Juliana Puppi;Stephen C. Strom;Robin D. Hughes;Sanjay Bansal

  229
  Citations

• Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS.

  M.José Gómez-Lechón;Xavier Ponsoda;Enrique O’Connor;Teresa Donato

  223
  Citations