What is he best known for?
The fields of study he is best known for:
José V. Castell spends much of his time researching Biochemistry, Drug metabolism, Cytochrome P450, Molecular biology and Hepatocyte.
His work carried out in the field of Biochemistry brings together such families of science as Cell culture, Steatosis and Fatty liver.
His Drug metabolism research is multidisciplinary, incorporating elements of In vitro and Drug development.
José V. Castell usually deals with In vitro and limits it to topics linked to In vivo and Drug.
His Molecular biology research includes themes of CYP2B6, Transcription factor, Expression vector, Messenger RNA and Isozyme.
His Hepatocyte research incorporates themes from Endocrinology, Apoptosis, Internal medicine, Transplantation and Cell biology.
His most cited work include:
- A human hepatocellular in vitro model to investigate steatosis. (317 citations)
- Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells (224 citations)
- Human hepatocytes in primary culture: the choice to investigate drug metabolism in man. (209 citations)
What are the main themes of his work throughout his whole career to date?
José V. Castell mainly investigates Biochemistry, Pharmacology, Hepatocyte, Molecular biology and Cytochrome P450.
His Pharmacology research is multidisciplinary, incorporating perspectives in In vitro, Toxicity and In vivo.
His work deals with themes such as Cell culture, Apoptosis, Glutathione, Cell biology and Transplantation, which intersect with Hepatocyte.
His Cell culture research integrates issues from Endocrinology, Internal medicine, Hepatic stellate cell, Monooxygenase and Methylcholanthrene.
José V. Castell combines subjects such as Hepatocyte nuclear factor 4 alpha, Transcription factor, Hepatocyte nuclear factors and Messenger RNA with his study of Molecular biology.
José V. Castell has researched Drug metabolism in several fields, including Drug development, Enzyme inducer and Fatty liver.
He most often published in these fields:
- Biochemistry (26.83%)
- Pharmacology (26.34%)
- Hepatocyte (19.02%)
What were the highlights of his more recent work (between 2016-2021)?
- Internal medicine (17.07%)
- Pharmacology (26.34%)
- Drug (12.20%)
In recent papers he was focusing on the following fields of study:
His main research concerns Internal medicine, Pharmacology, Drug, In vivo and Liver injury.
His studies in Internal medicine integrate themes in fields like Liver X receptor, Endocrinology, Pregnane X receptor and Oncology.
His In vivo study integrates concerns from other disciplines, such as Cell, Pharmacokinetics, In vitro, Drug development and Toxicity.
His In vitro research is multidisciplinary, incorporating elements of Molecular biology, Cell culture and Induced pluripotent stem cell.
His Toxicity study combines topics in areas such as EC50, Animal testing, Adverse effect and Drug metabolism.
The Drug metabolism study combines topics in areas such as CYP2B6 and Cytochrome P450, CYP2E1.
Between 2016 and 2021, his most popular works were:
- Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations (40 citations)
- Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers (28 citations)
- Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers (28 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Gene
- Internal medicine
José V. Castell mostly deals with Pharmacology, Internal medicine, Drug, Toxicity and Fatty liver.
His Internal medicine research incorporates elements of Serum microrna and Oncology.
The concepts of his Drug study are interwoven with issues in Microarray, Fenofibrate and Cyclosporin a.
The various areas that José V. Castell examines in his Toxicity study include EC50, CYP2B6, Drug metabolism and Cytochrome P450, CYP2E1.
José V. Castell has included themes like Steatosis, Endocrinology, Gene knockdown, Hepatocyte and Calcitriol receptor in his Fatty liver study.
His research in Liver injury intersects with topics in Pharmacokinetics, Cmax and In vivo.
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