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D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
29650
World Ranking
2122
National Ranking
45

Research.com Recognitions

  • 2016 - Royal Netherlands Academy of Arts and Sciences

Overview

Rob Leurs is affiliated with Vrije Universiteit Amsterdam in the Netherlands and has an extensive research portfolio focused on molecular biology and receptor mechanisms.

Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine. Subfields of study include Molecular Biology, Immunology, Oncology, Materials Chemistry, and Cellular and Molecular Neuroscience.

Key topics addressed in their work are:

  • Receptor Mechanisms and Signaling
  • Mast cells and histamine
  • Photochromic and Fluorescence Chemistry
  • Chemokine receptors and signaling
  • Trypanosoma species research and implications
  • Research on Leishmaniasis Studies
  • Olfactory and Sensory Function Studies

Rob Leurs has published frequently in several academic venues, highlighting ongoing research activity across different scientific forums. The most common publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • International Journal of Molecular Sciences
  • Biomolecules
  • Molecular Pharmacology

Their recent papers showcase a focus on histamine signaling, receptor biosensors, and chemokine receptor dynamics. Notable publications are:

  • "Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine", 2021, Biomolecules
  • "Genetically encoded sensors for measuring histamine release both in vitro and in vivo", 2023, Neuron
  • "Optical control of Class A G protein-coupled receptors with photoswitchable ligands", 2022, Current Opinion in Pharmacology
  • "Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists", 2020, ACS Sensors
  • "Conformational dynamics underlying atypical chemokine receptor 3 activation", 2024, Proceedings of the National Academy of Sciences

Leurs collaborates frequently with a group of researchers, indicating a consistent collaborative network. Frequent coauthors include:

  • Henry F. Vischer
  • Iwan J. P. de Esch
  • Maikel Wijtmans
  • Reggie Bosma
  • Barbara Zarzycka

In recognition of contributions to science, Leurs was awarded membership in the Royal Netherlands Academy of Arts and Sciences in 2016.

Best Publications

  • Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation

    Martial Ruat;Elisabeth Traiffort;Rob Leurs;Joel Tardivel-Lacombe

  • The histamine H3 receptor: from gene cloning to H3 receptor drugs

    Rob Leurs;Remko A. Bakker;Henk Timmerman;Iwan J. P. de Esch

  • H1‐antihistamines: inverse agonism, anti‐inflammatory actions and cardiac effects

    R. Leurs;M. K. Church;M. Taglialatela

  • International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

    Pertti Panula;Paul L. Chazot;Marlon Cowart;Ralf Gutzmer

  • A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation.

    M. Ruat;E. Traiffort;J.M. Arrang;J. Tardivellacombe

  • Molecular pharmacological aspects of histamine receptors.

    R Leurs;M.J Smit;H Timmerman

  • Evaluation of Histamine H1-, H2-, and H3-Receptor Ligands at the Human Histamine H4 Receptor: Identification of 4-Methylhistamine as the First Potent and Selective H4 Receptor Agonist

    Herman D. Lim;Richard M. van Rijn;Ping Ling;Remko A. Bakker

  • Therapeutic potential of Histamine H3 receptor agonists and antagonists

    R. Leurs;P. Blandina;C. Tedford;H. Timmerman

  • Identification of Rat H3 Receptor Isoforms with Different Brain Expression and Signaling Properties

    Guillaume Drutel;Nina Peitsaro;Kaj Karlstedt;Kerstin Wieland

  • Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling.

    Remko A. Bakker;Stefan B. J. Schoonus;Martine J. Smit;Henk Timmerman

  • The histamine H4 receptor as a new therapeutic target for inflammation

    Iwan J.P. de Esch;Robin L. Thurmond;Aldo Jongejan;Rob Leurs

  • Constitutive Signaling of the Human Cytomegalovirus-encoded Chemokine Receptor US28 *

    Paola Casarosa;Remko A. Bakker;Dennis Verzijl;Marjon Navis

  • KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.

    Oscar P J van Linden;Albert J Kooistra;Rob Leurs;Iwan J P de Esch

  • Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis

    David Maussang;Dennis Verzijl;Marijke van Walsum;Rob Leurs

  • Pharmacological modulation of chemokine receptor function

    DJ Scholten;M Canals;D Maussang;L Roumen

  • Inhibition of cortical acetylcholine release and cognitive performance by histamine H3 receptor activation in rats

    P. Blandina;M. Giorgetti;L. Bartolini;M. Cecchi

  • Keynote review: histamine H3 receptor antagonists reach out for the clinic.

    Sylvain Celanire;Maikel Wijtmans;Patrice Talaga;Rob Leurs

  • Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

    M J Smit;R Leurs;A E Alewijnse;J Blauw

  • CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

    Sven Jähnichen;Christophe Blanchetot;David Maussang;Maria Gonzalez-Pajuelo

  • The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor

    Astrid E. Alewijnse;Henk Timmerman;Edwin H. Jacobs;Martine J. Smit

Frequent Co-Authors

Martine J. Smit
Martine J. Smit Vrije Universiteit Amsterdam
Iwan J. P. de Esch
Iwan J. P. de Esch Vrije Universiteit Amsterdam
Aalt Bast
Aalt Bast Maastricht University
Chris de Graaf
Chris de Graaf Vrije Universiteit Amsterdam
Lindsay B. Hough
Lindsay B. Hough Albany Medical Center Hospital
Pertti Panula
Pertti Panula University of Helsinki
Ralf Gutzmer
Ralf Gutzmer Hannover Medical School
Cornelis P. Tensen
Cornelis P. Tensen Leiden University Medical Center
Holger Stark
Holger Stark Max Planck Society
Takatoshi Mochizuki
Takatoshi Mochizuki Beth Israel Deaconess Medical Center

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