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D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
83168
World Ranking
4189
National Ranking
2050

Overview

Pere Puigserver is affiliated with Harvard University in the United States. Their research primarily spans biochemistry, genetics, and molecular biology, with a significant focus on medicine. They have contributed extensively to subfields such as molecular biology, physiology, cancer research, clinical biochemistry, and cell biology.

The main topics covered in their work include:

  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism
  • Metabolism and Genetic Disorders
  • Cancer, Hypoxia, and Metabolism
  • RNA modifications and cancer
  • Metabolism, Diabetes, and Cancer
  • ATP Synthase and ATPases Research

Puigserver has published numerous articles, with recent papers including:

  • "Mechanisms of mitochondrial respiratory adaptation" (2022), published in Nature Reviews Molecular Cell Biology
  • "Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death" (2020), published in Nature Communications
  • "A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation" (2021), published in Cell Metabolism
  • "GCN5 acetyltransferase in cellular energetic and metabolic processes" (2020), published in Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  • "H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP" (2020), published in Journal of Clinical Investigation

The scientist frequently collaborates with other researchers, including Pedro Latorre-Muro, Christopher F. Bennett, Steven P. Gygi, Mark P. Jedrychowski, and Jiaxin Liang.

Puigserver's work has appeared in several publication venues, with multiple papers published in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Cell Metabolism
  • Cancer Research

Best Publications

  • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

    Vamsi K Mootha;Cecilia M Lindgren;Cecilia M Lindgren;Karl-Fredrik Eriksson;Aravind Subramanian

  • Resveratrol improves health and survival of mice on a high-calorie diet

    Joseph A. Baur;Kevin J. Pearson;Nathaniel O Price;Hamish A. Jamieson

  • Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

    Zhidan Wu;Pere Puigserver;Ulf Andersson;Chenyu Zhang

  • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

    Marie Lagouge;Carmen Argmann;Zachary Gerhart-Hines;Hamid Meziane

  • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

    Pere Puigserver;Zhidan Wu;Cheol Won Park;Reed Graves

  • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

    Joseph T. Rodgers;Carlos Lerin;Wilhelm Haas;Steven P. Gygi

  • AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity

    Carles Cantó;Zachary Gerhart-Hines;Jerome N. Feige;Marie Lagouge

  • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.

    Pere Puigserver;Bruce M. Spiegelman

  • Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

    Jiandie Lin;Hai Wu;Paul T. Tarr;Chen Yu Zhang

  • Transcriptional regulation of adipogenesis

    Evan D. Rosen;Christopher J. Walkey;Pere Puigserver;Bruce M. Spiegelman

  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.

    J. Cliff Yoon;Pere Puigserver;Guoxun Chen;Jerry Donovan

  • CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

    Stephan Herzig;Fanxin Long;Fanxin Long;Ulupi S. Jhala;Susan Hedrick

  • mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

    John T. Cunningham;Joseph T. Rodgers;Daniel H. Arlow;Francisca Vazquez

  • Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction

    Pere Puigserver;James Rhee;Jerry Donovan;Christopher J. Walkey

  • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

    Zachary Gerhart-Hines;Zachary Gerhart-Hines;Joseph T. Rodgers;Joseph T. Rodgers;Olivia Bare;Carles Lerin;Carles Lerin

  • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

    Dohoon Kim;Dohoon Kim;Minh Dang Nguyen;Matthew M. Dobbin;Andre Fischer

  • Antioxidant and Oncogene Rescue of Metabolic Defects Caused by Loss of Matrix Attachment

    Zachary T. Schafer;Alexandra R. Grassian;Loling Song;Zhenyang Jiang

  • Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

    Pere Puigserver;James Rhee;Jiandie Lin;Zhidan Wu

  • Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

    Laura F. Michael;Zhidan Wu;R. Bentley Cheatham;Pere Puigserver

  • Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

    Vamsi K. Mootha;Christoph Handschin;Dan Arlow;Xiaohui Xie

Frequent Co-Authors

Bruce M. Spiegelman
Bruce M. Spiegelman Harvard University
Mark P. Jedrychowski
Mark P. Jedrychowski Harvard University
Steven P. Gygi
Steven P. Gygi Harvard University
Francisca Vazquez
Francisca Vazquez Broad Institute
Andreu Palou
Andreu Palou University of the Balearic Islands
Vamsi K. Mootha
Vamsi K. Mootha Harvard Medical School
Jiandie D. Lin
Jiandie D. Lin University of Michigan–Ann Arbor
Patrick R. Griffin
Patrick R. Griffin Scripps Research Institute
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Bradford B. Lowell
Bradford B. Lowell Beth Israel Deaconess Medical Center

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