World's Best Scientists 2026 revealed!
Mark P. Jedrychowski

Mark P. Jedrychowski

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
37196
World Ranking
8025
National Ranking
3636

Overview

Mark P. Jedrychowski is affiliated with Harvard University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with specific attention to Molecular Biology, Physiology, Neurology, Cell Biology, and Immunology.

The scientist has contributed extensively to topics related to Adipose Tissue and Metabolism, Mitochondrial Function and Pathology, Neuroinflammation and Neurodegeneration Mechanisms, Immune cells in cancer, Cancer, Hypoxia, and Metabolism, Extracellular vesicles in disease, and Adipokines, Inflammation, and Metabolic Diseases.

Notable recent publications include:

  • Quantitative Proteomics of the Cancer Cell Line Encyclopedia, 2020, Cell
  • A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging, 2020, Cell
  • Exercise hormone irisin is a critical regulator of cognitive function, 2021, Nature Metabolism
  • Creatine kinase B controls futile creatine cycling in thermogenic fat, 2021, Nature
  • Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study, 2020, Cells

Frequent co-authors they have collaborated with include:

  • Steven P. Gygi
  • Bruce M. Spiegelman
  • Edward T. Chouchani
  • Pere Puigserver
  • Haopeng Xiao

The scientist's research is frequently published in venues such as:

  • Nature
  • Nature Metabolism
  • Cell Metabolism
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell

Best Publications

  • A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

    Pontus Boström;Jun Wu;Mark P. Jedrychowski;Anisha Korde

  • Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

    Anne Brunet;Lora B. Sweeney;J. Fitzhugh Sturgill;Katrin F. Chua

  • Identification of a unique TGF-β–dependent molecular and functional signature in microglia

    Oleg Butovsky;Mark P Jedrychowski;Craig S Moore;Ron Cialic

  • A tissue-specific atlas of mouse protein phosphorylation and expression.

    Edward L. Huttlin;Mark P. Jedrychowski;Joshua E. Elias;Tapasree Goswami

  • Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

    Evanna L Mills;Dylan G Ryan;Hiran A Prag;Dina Dikovskaya

  • Large-scale characterization of HeLa cell nuclear phosphoproteins.

    Sean A. Beausoleil;Mark Jedrychowski;Daniel Schwartz;Joshua E. Elias

  • MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

    Graeme C. McAlister;David P. Nusinow;Mark P. Jedrychowski;Martin Wühr

  • Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

    Rajesh R. Rao;Jonathan Z. Long;James P. White;Katrin J. Svensson

  • Quantitative Proteomics of the Cancer Cell Line Encyclopedia

    David P. Nusinow;John Szpyt;Mahmoud Ghandi;Christopher M. Rose

  • A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

    Lawrence Kazak;Edward T. Chouchani;Mark P. Jedrychowski;Brian K. Erickson

  • Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

    Alban Ordureau;Shireen A. Sarraf;David M. Duda;Jin-Mi Heo

  • Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses.

    Graeme C. McAlister;Edward L. Huttlin;Wilhelm Haas;Lily Ting

  • Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.

    Mark P. Jedrychowski;Christiane D. Wrann;Joao A. Paulo;Kaitlyn K. Gerber

  • Plasticity in binding confers selectivity in ligand-induced protein degradation.

    Radosław P. Nowak;Stephen L. DeAngelo;Dennis Buckley;Zhixiang He

  • Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

    Hyeonwoo Kim;Christiane D. Wrann;Mark Jedrychowski;Sara Vidoni

  • Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

    Oleg Butovsky;Mark P. Jedrychowski;Ron Cialic;Susanne Krasemann

  • Accumulation of succinate controls activation of adipose tissue thermogenesis.

    Evanna L. Mills;Kerry A. Pierce;Mark P. Jedrychowski;Ryan Garrity

  • Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

    Edward T. Chouchani;Lawrence Kazak;Mark P. Jedrychowski;Gina Z. Lu

  • The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD +

    Zachary Gerhart-Hines;Zachary Gerhart-Hines;John E. Dominy;Sharon M. Blättler;Mark P. Jedrychowski

  • Erratum: Identification of a unique TGF-β-dependent molecular and functional signature in microglia (Nature Neuroscience (2014) 17 (131-143))

    Oleg Butovsky;Mark P. Jedrychowski;Craig S. Moore;Ron Cialic

Frequent Co-Authors

Steven P. Gygi
Steven P. Gygi Harvard University
Bruce M. Spiegelman
Bruce M. Spiegelman Harvard University
Pere Puigserver
Pere Puigserver Harvard University
Joao A. Paulo
Joao A. Paulo Harvard University
Patrick R. Griffin
Patrick R. Griffin Scripps Research Institute
Shingo Kajimura
Shingo Kajimura Beth Israel Deaconess Medical Center
Lydia Lynch
Lydia Lynch Brigham and Women's Hospital
Tsuneya Ikezu
Tsuneya Ikezu Boston University
Evan D. Rosen
Evan D. Rosen Beth Israel Deaconess Medical Center
Oleg Butovsky
Oleg Butovsky Brigham and Women's Hospital

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