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Biology and Biochemistry

D-Index
68
Citations
33509
World Ranking
7613
National Ranking
3462

Overview

Tsuneya Ikezu is affiliated with Boston University in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, neuroscience, and medicine. Their work spans a range of subfields, including molecular biology, neurology, physiology, immunology, and cancer research.

The primary topics of Tsuneya Ikezu's research focus on neuroinflammation and neurodegeneration mechanisms, extracellular vesicles in disease, Alzheimer's disease research and treatments, immune cells in cancer, microRNA in disease regulation, cell adhesion molecules research, and adenosine and purinergic signaling.

Recent publications by Tsuneya Ikezu include:

  • Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons, 2020, Brain
  • Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model, 2021, Molecular Neurodegeneration
  • Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study, 2020, Cells
  • Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues, 2020, Alzheimer s & Dementia
  • APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints, 2023, Nature Immunology

Frequent co-authors collaborating with Tsuneya Ikezu include:

  • Seiko Ikezu
  • Yang You
  • Zhi Ruan
  • Jean-Christophe Delpech
  • Satoshi Muraoka

Tsuneya Ikezu has been published most frequently in the following venues:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Extracellular Vesicles
  • Molecular Neurodegeneration
  • Acta Neuropathologica Communications

Best Publications

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Clotilde Théry;Kenneth W. Witwer;Elena Aikawa;Maria Jose Alcaraz

  • The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

    Susanne Krasemann;Susanne Krasemann;Charlotte Madore;Ron Cialic;Caroline Baufeld

  • The spectrum of disease in chronic traumatic encephalopathy

    Ann C. McKee;Thor D. Stein;Thor D. Stein;Christopher J. Nowinski;Robert A. Stern

  • Depletion of microglia and inhibition of exosome synthesis halt tau propagation

    Hirohide Asai;Seiko Ikezu;Satoshi Tsunoda;Maria Medalla

  • Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain IMPLICATIONS FOR THE INTERACTION OF CAVEOLIN WITH CAVEOLAE-ASSOCIATED PROTEINS

    Jacques Couet;Shengwen Li;Takashi Okamoto;Tsuneya Ikezu

  • Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

    Lee E. Goldstein;Andrew M. Fisher;Chad A. Tagge;Xiao-Lei Zhang

  • Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain.

    Jeffrey A. Engelman;Caryn Chu;Anning Lin;Hanjoong Jo

  • The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain.

    Megan M. Varnum;Tsuneya Ikezu

  • Interferon-γ and Tumor Necrosis Factor-α Regulate Amyloid-β Plaque Deposition and β-Secretase Expression in Swedish Mutant APP Transgenic Mice

    Masaru Yamamoto;Tomomi Kiyota;Masahide Horiba;James L. Buescher

  • Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

    Masaru Yamamoto;Servio H. Ramirez;Shinji Sato;Tomomi Kiyota

  • Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane RETENTION OF CAVEOLIN-2 AT THE LEVEL OF THE GOLGI COMPLEX

    Isabella Parolini;Isabella Parolini;Massimo Sargiacomo;Ferruccio Galbiati;Giovanni Rizzo

  • Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

    Daniel J. Apicco;Peter E. A. Ash;Brandon Maziuk;Chelsey LeBlang

  • Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE).

    Yuri Persidsky;David Heilman;David Heilman;James Haorah;James Haorah;Marina Zelivyanskaya;Marina Zelivyanskaya

  • Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration.

    Maya E. Woodbury;Tsuneya Ikezu

  • Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.

    Tara Vanderweyde;Haung Yu;Megan Varnum;Liqun Liu-Yesucevitz

  • CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice

    Tomomi Kiyota;Satoshi Okuyama;Russell J. Swan;Michael T. Jacobsen

  • Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types.

    Tsuneya Ikezu;Hideho Ueda;Bruce D Trapp;Kazutoshi Nishiyama

  • AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice.

    Tomomi Kiyota;Kaitlin L. Ingraham;Russell J. Swan;Michael T. Jacobsen

  • Caveolae, Plasma Membrane Microdomains for α-Secretase-mediated Processing of the Amyloid Precursor Protein *

    Tsuneya Ikezu;Bruce D. Trapp;Kenneth S. Song;Amnon Schlegel

  • Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.

    Robert W. Freilich;Maya E. Woodbury;Tsuneya Ikezu

Frequent Co-Authors

Howard E. Gendelman
Howard E. Gendelman University of Nebraska Medical Center
Benjamin Wolozin
Benjamin Wolozin Boston University
Ikuo Nishimoto
Ikuo Nishimoto Keio University
Carmela R. Abraham
Carmela R. Abraham Boston University
Lindsay A. Farrer
Lindsay A. Farrer Boston University
Steven P. Gygi
Steven P. Gygi Harvard University
Michael P. Lisanti
Michael P. Lisanti University of Salford
Mark P. Jedrychowski
Mark P. Jedrychowski Harvard University
Jennifer I. Luebke
Jennifer I. Luebke Boston University
Joseph Zaia
Joseph Zaia Boston University

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