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Chemistry

D-Index
69
Citations
13207
World Ranking
6363
National Ranking
414

Overview

Kiyoshi Tomioka is affiliated with Doshisha Women's College of Liberal Arts in Japan and has contributed to the field of Chemistry with a particular focus on Pharmacology and Organic Chemistry. Their research primarily addresses the synthesis and pharmacology of alkaloids, with a detailed interest in berberine and related compounds.

Their recent publication record includes works on synthetic organic chemistry methods, specifically involving hydroamination strategies and the construction of complex alkaloid frameworks. Notable papers include:

  • Asymmetric total synthesis of (−)-javaberine A and (−)-epi-javaberine A based on catalytic intramolecular hydroamination of N-methyl-2-(2-styrylaryl)ethylamine, 2021, Tetrahedron
  • Phosphazene base-catalyzed hydroamination of aminoalkenes for the construction of isoindoline scaffolds: Application to the total synthesis of aristocularine, 2021, Tetrahedron Letters
  • Stereoselective Synthesis of Diastereomeric Berberine Alkaloids, O-Methylcorytenchirine and Coralydine, 2021, Heterocycles
  • Synthetic studies on javaberine A: Construction of the tetrahydroprotoberberine framework based on a double hydroamination strategy, 2023, Tetrahedron
  • Issue Information, 2021, Physiological Entomology

Their frequent coauthors include Yasutomo Yamamoto, Junpei Matsuoka, Akari Miyawaki, Timothy J. Bruce, and A Appel.

Publication venues for Tomioka's work span several journals, including:

  • Physiological Entomology
  • Tetrahedron
  • Tetrahedron Letters
  • Heterocycles
  • SSRN Electronic Journal

The core fields of study encompass:

  • Chemistry

With subfields focusing on:

  • Pharmacology
  • Organic Chemistry
  • Biochemistry
  • Insect Science
  • Genetics

Key research topics include:

  • Alkaloids: synthesis and pharmacology
  • Berberine and alkaloids research
  • Traditional and Medicinal Uses of Annonaceae
  • Synthesis and pharmacology of benzodiazepine derivatives
  • Oxidative Organic Chemistry Reactions
  • Synthetic Organic Chemistry Methods
  • Insect and Pesticide Research

The collective work supports ongoing developments in the synthesis of complex alkaloid structures and their pharmacological applications, emphasizing organic synthesis techniques and natural product chemistry.

Best Publications

  • Copper-catalyzed asymmetric alkylation of imines with dialkylzinc and related reactions.

    Ken-ichi Yamada;Kiyoshi Tomioka

  • N-Boc-L-valine-connected amidomonophosphane rhodium(I) catalyst for asymmetric arylation of N-tosylarylimines with arylboroxines.

    Masami Kuriyama;Takahiro Soeta;Xinyu Hao;Qian Chen

  • Asymmetric Synthesis Utilizing External Chiral Ligands

    Kiyoshi Tomioka

  • Hemilabile amidomonophosphine ligand-rhodium(I) complex-catalyzed asymmetric 1,4-addition of arylboronic acids to cycloalkenones.

    Masami Kuriyama;Kazushige Nagai;Ken-Ichi Yamada;Yoshinao Miwa

  • A Ternary Complex Reagent for an Asymmetric Reaction of Lithium Ester Enolates with Imines

    Hiroki Fujieda;Motomu Kanai;Takeshi Kambara;and Akira Iida

  • Copper−Amidophosphine Catalyst in Asymmetric Addition of Organozinc to Imines

    Hidetaka Fujihara;and Kazushige Nagai;Kiyoshi Tomioka

  • C2 Symmetric Chiral NHC Ligand for Asymmetric Quaternary Carbon Constructing Copper-Catalyzed Conjugate Addition of Grignard Reagents to 3-Substituted Cyclohexenones

    Yasumasa Matsumoto;Ken-ichi Yamada;Kiyoshi Tomioka

  • Novel Strategy of Using a C2 Symmetric Chiral Diether in the Enantioselective Conjugate Addition of an Organolithium to an α,β-Unsaturated Aldimine†

    Kiyoshi Tomioka;Mitsuru Shindo;Kenji Koga

  • Dimethylzinc-Initiated Radical Reactions

    Tito Akindele;Ken-ichi Yamada;Kiyoshi Tomioka

  • Enantioface differentiation in cis dihydroxylation of carbon-carbon double bonds by osmium tetroxide using a chiral diamine with D2 symmetry

    Kiyoshi Tomioka;Makoto Nakajima;Kenji Koga

  • Efficient Chiral N‐Heterocyclic Carbene/Copper(I)‐Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents

    Khalid B. Selim;Yasumasa Matsumoto;Ken-ichi Yamada;Kiyoshi Tomioka

  • Steric Tuning of Reactivity and Enantioselectivity in Addition of Thiophenol to Enoates Catalyzed by an External Chiral Ligand

    Katsumi Nishimura;Masashi Ono;Yasuo Nagaoka;Kiyoshi Tomioka

  • Asymmetric alkylation of .alpha.-alkyl .beta.-keto esters

    Kiyoshi Tomioka;Kaori Ando;Yutaka Takemasa;Kenji Koga

  • Catalytic asymmetric intramolecular hydroamination of aminoalkenes

    Tokutaro Ogata;Atsushi Ujihara;Susumu Tsuchida;Tomoko Shimizu

  • Asymmetric organolithium additions to imines

    Kiyoshi Tomioka;Isao Inoue;Mitsuru Shindo;Kenji Koga

  • A catalytic method for asymmetric nucleophilic aromatic substitution giving binaphthyls

    Mitsuru Shindo;Mitsuru Shindo;Kenji Koga;Kenji Koga;Kiyoshi Tomioka;Kiyoshi Tomioka

  • Asymmetric total synthesis of natural (-)-and unnatural (+)-steganacin ☆ ☆☆: Determination of the absolute configuration of natural antitumor steganacin

    Kiyoshi Tomioka;Tsuneo Ishiguro;Yōichi Iitaka;Kenji Koga

  • Radical addition of ethers to imines initiated by dimethylzinc.

    Ken-ichi Yamada;Hidetaka Fujihara;Yasutomo Yamamoto;Yoshihisa Miwa

  • Design, Synthesis, and Application of a C2 Symmetric Chiral Ligand for Enantioselective Conjugate Addition of Organolithium to α,β-Unsaturated Aldimine

    Mitsuru Shindo;Kenji Koga;Kiyoshi Tomioka

  • Chiral amidomonophosphine-rhodium(I) catalyst for asymmetric 1,4-addition of arylboronic acids to cycloalkenones

    Masami Kuriyama;Kiyoshi Tomioka

Frequent Co-Authors

Kenji Koga
Kenji Koga Nara Institute of Science and Technology
Motomu Kanai
Motomu Kanai University of Tokyo
Osamu Muraoka
Osamu Muraoka Kindai University
Yasuhisa Asano
Yasuhisa Asano Toyama Prefectural University
Hiroaki Ohno
Hiroaki Ohno Kyoto University
Yoichi Iitaka
Yoichi Iitaka University of Tokyo
Shunichi Hashimoto
Shunichi Hashimoto Ritsumeikan University
Albert I. Meyers
Albert I. Meyers Colorado State University
Ichiro Takahashi
Ichiro Takahashi Hiroshima University
Yoshiyuki Kubota
Yoshiyuki Kubota The Graduate University for Advanced Studies, SOKENDAI

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