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Biology and Biochemistry

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81
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22800
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3911
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59

Medicine

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Overview

Mikael Rydén is affiliated with Karolinska University Hospital in Sweden. Their research primarily focuses on Medicine, with significant contributions in Biochemistry, Genetics and Molecular Biology. The scientist's work spans several subfields including Physiology, Molecular Biology, Epidemiology, Immunology, and Cardiology and Cardiovascular Medicine.

The main research topics covered by Mikael Rydén include:

  • Adipose Tissue and Metabolism
  • Adipokines, Inflammation, and Metabolic Diseases
  • Lipid metabolism and biosynthesis
  • Diet and metabolism studies
  • Cardiovascular Disease and Adiposity
  • Single-cell and spatial transcriptomics
  • Diabetes and associated disorders

Rydén has published extensively, with recent papers including:

  • "Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin" (2021, Cell Metabolism)
  • "An integrated single cell and spatial transcriptomic map of human white adipose tissue" (2023, Nature Communications)
  • "Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial" (2021, The Lancet Diabetes & Endocrinology)
  • "In vitro and ex vivo models of adipocytes" (2021, American Journal of Physiology-Cell Physiology)
  • "Adipose tissue retains an epigenetic memory of obesity after weight loss" (2024, Nature)

Frequent co-authors collaborating with Mikael Rydén include:

  • Niklas Mejhert (26 joint publications)
  • Peter Arner (22 joint publications)
  • Lucas Massier (19 joint publications)
  • Daniel P. Andersson (13 joint publications)
  • Anna Krook (11 joint publications)

Rydén's research has appeared repeatedly in several notable publication venues such as:

  • Nature Metabolism (6 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (6 publications)
  • Cell Metabolism (5 publications)
  • International Journal of Obesity (5 publications)
  • Diabetes (5 publications)

The scope and focus of Mikael Rydén's work relate extensively to metabolism and associated diseases, with emphasis on the cellular and molecular mechanisms of adipose tissue. Their contributions also cover advanced methods such as single-cell and spatial transcriptomics, which are employed to better understand tissue heterogeneity and metabolic function.

Best Publications

  • Dynamics of fat cell turnover in humans

    Kirsty L Spalding;Erik Arner;Pål O Westermark;Samuel Bernard

  • Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.

    M Trupp;M Rydén;H Jörnvall;H Funakoshi

  • Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

    Erik Arner;Pål O Westermark;Kirsty L Spalding;Tom Britton

  • Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

    Daniela Lamers;Susanne Famulla;Nina Wronkowitz;Sonja Hartwig

  • Adipocyte Lipases and Defect of Lipolysis in Human Obesity

    Dominique Langin;Andrea Dicker;Geneviève Tavernier;Johan Hoffstedt

  • Functional studies of mesenchymal stem cells derived from adult human adipose tissue.

    Andrea Dicker;Katarina Le Blanc;Gaby Åström;Vanessa van Harmelen

  • Dynamics of human adipose lipid turnover in health and metabolic disease

    Peter Arner;Samuel Bernard;Mehran Salehpour;Göran Possnert

  • Mechanism of Increased Lipolysis in Cancer Cachexia

    Thorhallur Agustsson;Mikael Rydén;Johan Hoffstedt;Vanessa van Harmelen

  • Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity

    Erik Arner;Niklas Mejhert;Agné Kulyté;Piotr J. Balwierz

  • Mapping of Early Signaling Events in Tumor Necrosis Factor-α-mediated Lipolysis in Human Fat Cells

    Mikael Rydén;Andrea Dicker;Vanessa van Harmelen;Vanessa van Harmelen;Hans Hauner

  • FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity.

    Peter Arner;Amanda Pettersson;Pamela J. Mitchell;James D. Dunbar

  • Targets for TNF-α-induced lipolysis in human adipocytes

    Mikael Rydén;Elisabet Arvidsson;Lennart Blomqvist;Leif Perbeck

  • Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes.

    Véronic Bezaire;Véronic Bezaire;Aline Mairal;Aline Mairal;Carole Ribet;Carole Ribet;Corinne Lefort;Corinne Lefort

  • Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity.

    J. Hoffstedt;E. Arner;H. Wahrenberg;D. P. Andersson

  • A Human-Specific Role of Cell Death-Inducing DFFA (DNA Fragmentation Factor-α)-Like Effector A (CIDEA) in Adipocyte Lipolysis and Obesity

    Elisabet Arvidsson Nordström;Mikael Rydén;Emma C. Backlund;Ingrid Dahlman

  • Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes

    Vanessa van Harmelen;Andrea Dicker;Mikael Rydén;Hans Hauner

  • A Unique Defect in the Regulation of Visceral Fat Cell Lipolysis in the Polycystic Ovary Syndrome as an Early Link to Insulin Resistance

    Ingvar Ek;Peter Arner;Mikael Rydén;Cecilia Holm

  • Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis

    S. Mottagui-Tabar;M. Rydén;P. Löfgren;G. Faulds

  • Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes

    Juan R. Acosta;Iyadh Douagi;Daniel P. Andersson;Jesper Bäckdahl

  • Expression of nitric oxide synthases in subcutaneous adipose tissue of nonobese and obese humans.

    Montserrat Elizalde;Mikael Rydén;Vanessa van Harmelen;Peter Eneroth

Frequent Co-Authors

Peter Arner
Peter Arner Karolinska Institute
Ingrid Dahlman
Ingrid Dahlman Karolinska Institute
Carlos F. Ibáñez
Carlos F. Ibáñez Karolinska Institute
Karin Dahlman-Wright
Karin Dahlman-Wright Karolinska Institute
Carsten O. Daub
Carsten O. Daub Karolinska Institute
Juleen R. Zierath
Juleen R. Zierath Karolinska Institute
Hans Hauner
Hans Hauner Technical University of Munich
Cecilia Holm
Cecilia Holm Lund University
Per Eriksson
Per Eriksson Karolinska University Hospital

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