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D-Index & Metrics

Biology and Biochemistry

D-Index
45
Citations
13800
World Ranking
19041
National Ranking
668

Overview

Pamela A. Hoodless is affiliated with the University of British Columbia in Canada. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. The subfields most represented in their work include Molecular Biology, Cancer Research, Hepatology, Surgery, and Genetics.

Their contributions focus on several main research topics, including:

  • Cancer-related molecular mechanisms research
  • Liver physiology and pathology
  • Congenital heart defects research
  • Pancreatic function and diabetes
  • Single-cell and spatial transcriptomics
  • Protein degradation and inhibitors
  • RNA modifications and cancer

Hoodless has published in frequent venues such as Communications Biology, Blood, Cell, Nature Reviews Gastroenterology & Hepatology, and Nucleic Acids Research. Notably, Communications Biology and Blood each host at least two of their works.

Their recent papers include:

  • Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020, Cell)
  • G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression (2021, Communications Biology)
  • Fetal liver development and implications for liver disease pathogenesis (2023, Nature Reviews Gastroenterology & Hepatology)
  • SOX9 reprograms endothelial cells by altering the chromatin landscape (2022, Nucleic Acids Research)
  • Signalling pathways and transcriptional regulators orchestrating liver development and cancer (2021, Development)

Collaborations have been extensive, with frequent coauthors including Jeremy Lotto, Sibyl Drissler, Rebecca Cullum, Tabea L. Stephan, and Avinash Thakur. Jeremy Lotto appears as a coauthor in multiple papers and is the most frequent collaborator.

Best Publications

  • De novo assembly and analysis of RNA-seq data

    Gordon Robertson;Jacqueline Schein;Readman Chiu;Richard Corbett

  • MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

    Kolja Eppert;Stephen W Scherer;Hilmi Ozcelik;Rosa Pirone

  • MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

    Marina Macías-Silva;Shirin Abdollah;Pamela A Hoodless;Rosa Pirone

  • MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

    Pamela A Hoodless;Theo Haerry;Shirin Abdollah;Mark Stapleton

  • The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

    Daniel C. Weinstein;Ariel Ruiz i Altaba;William S. Chen;Pamela Hoodless

  • Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

    Etienne Labbé;Cristoforo Silvestri;Pamela A. Hoodless;Jeffrey L. Wrana

  • Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

    Marina Macı́as-Silva;Pamela A. Hoodless;Shao Jun Tang;Manuel Buchwald

  • Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.

    W.Ross Waldrip;Elizabeth K Bikoff;Pamela A Hoodless;Jeffrey L Wrana

  • Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst

    Stephen A. Duncan;Katia Manova;William S. Chen;Pamela Hoodless

  • Slug is a direct Notch target required for initiation of cardiac cushion cellularization

    Kyle Niessen;YangXin Fu;YangXin Fu;Linda Chang;Pamela A. Hoodless;Pamela A. Hoodless

  • Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect

    Michelle B. Bowie;Kristen D. McKnight;David G. Kent;Lindsay McCaffrey

  • Notch Activation Results in Phenotypic and Functional Changes Consistent With Endothelial-to-Mesenchymal Transformation

    Michela Noseda;Graeme McLean;Kyle Niessen;Linda Chang

  • The emergent landscape of the mouse gut endoderm at single-cell resolution.

    Sonja Nowotschin;Manu Setty;Ying-Yi Kuo;Vincent Liu

  • Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties

    Michelle B. Bowie;David G. Kent;Brad Dykstra;Kristen D. McKnight

  • Formation of the definitive endoderm in mouse is a Smad2-dependent process

    Kimberly D. Tremblay;Pamela A. Hoodless;Elizabeth K. Bikoff;Elizabeth J. Robertson

  • FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse

    Pamela A. Hoodless;Melanie Pye;Claire Chazaud;Etienne Labbé

  • Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling

    Christian Sirard;Sammy Kim;Christine Mirtsos;Paul Tadich

  • Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding

    A. Gordon Robertson;Mikhail Bilenky;Angela Tam;Yongjun Zhao

  • Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing

    Elizabeth D. Wederell;Mikhail Bilenky;Rebecca Cullum;Nina Thiessen

  • Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase.

    Alex C.Y. Chang;YangXin Fu;Victoria C. Garside;Kyle Niessen

Frequent Co-Authors

Marco A. Marra
Marco A. Marra University of British Columbia
Steven J.M. Jones
Steven J.M. Jones University of British Columbia
Aly Karsan
Aly Karsan University of British Columbia
Jeffrey L. Wrana
Jeffrey L. Wrana Lunenfeld-Tanenbaum Research Institute
Martin Hirst
Martin Hirst University of British Columbia
Elizabeth M. Simpson
Elizabeth M. Simpson University of British Columbia
Reiner A. Veitia
Reiner A. Veitia Université Paris Cité
Peggy J. Farnham
Peggy J. Farnham University of Southern California
Inanc Birol
Inanc Birol University of British Columbia
Wyeth W. Wasserman
Wyeth W. Wasserman University of British Columbia

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