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Medicine

D-Index
99
Citations
43957
World Ranking
8481
National Ranking
4379

Overview

Boris C. Bastian is affiliated with the University of California, San Francisco in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with a substantial engagement in medicine. Their work spans several subfields including molecular biology, oncology, cancer research, cell biology, and ophthalmology.

The scientist's main research topics include cutaneous melanoma detection and management, cancer genomics and diagnostics, melanoma and MAPK pathways, ocular oncology and treatments, genomic variations and chromosomal abnormalities, melanin and skin pigmentation, and genomics and chromatin dynamics.

Frequent co-authors collaborating with Boris C. Bastian are:

  • Iwei Yeh
  • A. Hunter Shain
  • Meng Wang
  • Raymond J. Cho
  • Darwin Chang

The researcher's recent papers illustrate a focus on melanoma and cancer genomics. Selected recent works include:

  • The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway (2020), published in Archives of Pathology & Laboratory Medicine
  • Pervasive chromosomal instability and karyotype order in tumour evolution (2020), published in Nature
  • The genomic landscapes of individual melanocytes from human skin (2020), published in Nature
  • Spitz melanoma is a distinct subset of spitzoid melanoma (2020), published in Modern Pathology
  • Functional characterization of uveal melanoma oncogenes (2020), published in Oncogene

Bastian has published frequently in several venues, notably:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Modern Pathology
  • Nature
  • Nature Communications

Their scholarly contributions emphasize the molecular and genetic characterization of melanoma, exploring the evolutionary pathways and chromosomal instability of tumors, with a strong interdisciplinary approach involving molecular biology, oncology, and ophthalmology. The body of work addresses fundamental issues in cancer research and genomic diagnostics, contributing to the understanding of melanoma subtypes and oncogenes.

Best Publications

  • Distinct Sets of Genetic Alterations in Melanoma

    John A. Curtin;Jane Fridlyand;Toshiro Kageshita;Hetal N. Patel

  • Genomic Classification of Cutaneous Melanoma

    Rehan Akbani;Kadir C. Akdemir;B. Arman Aksoy;Monique Albert

  • Somatic Activation of KIT in Distinct Subtypes of Melanoma

    John A. Curtin;Klaus Busam;Daniel Pinkel;Boris C. Bastian

  • Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

    Catherine D. Van Raamsdonk;Vladimir Bezrookove;Gary G.R. Green;Jürgen Bauer

  • CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing

    Eric Talevich;A. Hunter Shain;Thomas Botton;Boris C. Bastian

  • Mutations in GNA11 in Uveal Melanoma

    Catherine D Van Raamsdonk;Klaus G Griewank;Michelle B Crosby;Maria C Garrido

  • The Genetic Evolution of Melanoma from Precursor Lesions

    A. Hunter Shain;Iwei Yeh;Ivanka Kovalyshyn;Aravindhan Sriharan

  • KIT as a therapeutic target in metastatic melanoma

    Richard D. Carvajal;Cristina R. Antonescu;Jedd D. Wolchok;Paul B. Chapman

  • From melanocytes to melanomas

    A. Hunter Shain;Boris C. Bastian

  • Determinants of BRAF Mutations in Primary Melanomas

    Janet L. Maldonado;Jane Fridlyand;Hetal Patel;Ajay N. Jain

  • Germline mutations in BAP1 predispose to melanocytic tumors

    Thomas Wiesner;Anna C Obenauf;Anna C Obenauf;Rajmohan Murali;Isabella Fried

  • Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

    Alexander Roesch;Adina Vultur;Ivan Bogeski;Huan Wang

  • Chromosomal Gains and Losses in Primary Cutaneous Melanomas Detected by Comparative Genomic Hybridization

    Boris C. Bastian;Philip E. LeBoit;Henning Hamm;Eva-Bettina Bröcker

  • The Prevalence and Prognostic Value of BRAF Mutation in Thyroid Cancer

    Electron Kebebew;Julie Weng;Juergen Bauer;Gustavo Ranvier

  • Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.

    Thomas Wiesner;Jie He;Roman Yelensky;Rosaura Esteve-Puig

  • The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia

    Boris C. Bastian

  • Classifying Melanocytic Tumors Based on DNA Copy Number Changes

    Boris C. Bastian;Adam B. Olshen;Philip E. LeBoit;Daniel Pinkel

  • Fluorescence In Situ Hybridization (FISH) as an Ancillary Diagnostic Tool in the Diagnosis of Melanoma

    Pedram Gerami;Susan S. Jewell;Larry E. Morrison;Beth Blondin

  • Mutations and Copy Number Increase of HRAS in Spitz Nevi with Distinctive Histopathological Features

    Boris C. Bastian;Philip E. LeBoit;Daniel Pinkel

  • Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

    Fa-Xing Yu;Jing Luo;Jung-Soon Mo;Guangbo Liu

Frequent Co-Authors

Philip E. LeBoit
Philip E. LeBoit University of California, San Francisco
Daniel Pinkel
Daniel Pinkel University of California, San Francisco
David A. Solomon
David A. Solomon University of California, San Francisco
Klaus J. Busam
Klaus J. Busam Memorial Sloan Kettering Cancer Center
Eva-B. Bröcker
Eva-B. Bröcker University of Würzburg
Richard A. Scolyer
Richard A. Scolyer Royal Prince Alfred Hospital
Arie Perry
Arie Perry University of California, San Francisco
Tarik Tihan
Tarik Tihan University of California, San Francisco
Joanna J. Phillips
Joanna J. Phillips University of California, San Francisco
Reinhard Dummer
Reinhard Dummer University of Zurich

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