World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
37323
World Ranking
3619
National Ranking
16

Research.com Recognitions

  • 2019 - Fellow, The World Academy of Sciences

Overview

Leroy F. Liu is affiliated with Taipei Medical University in Taiwan and primarily conducts research in the fields of Medicine as well as Biochemistry, Genetics and Molecular Biology. Their work intersects several subfields including Molecular Biology, Pathology and Forensic Medicine, Oncology, Cardiology and Cardiovascular Medicine, and Surgery.

The scientist's recent publications reflect a focus on cancer mechanisms, therapeutic approaches, and cardiovascular conditions. Notable papers include:

  • "Targeting METTL8 with Rabdosiin overcomes lenvatinib resistance in hepatocellular carcinoma" (2024, Experimental Cell Research)
  • "Correction: Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain" (2025, Experimental Hematology and Oncology)
  • "A network toxicology approach to decipher paraben-induced molecular dysregulation in breast cancer pathogenesis" (2025, Discover Oncology)
  • "Painful left bundle branch block syndrome: A case report" (2025, Journal of Electrocardiology)
  • "Letter to editor: detection of immune-mediated tumour cell death in vivo using Zirconium-89-labeled APOMAB®" (2025, Journal of Translational Medicine)

Frequent co-authors collaborating with Leroy F. Liu include Yunpeng Liu, Muhua Chen, Xiang-Xu Wang, Yuan Gao, and Han Xiao.

The scientist has published works in several venues, notably:

  • Experimental Cell Research
  • Experimental Hematology and Oncology
  • Discover Oncology
  • Journal of Electrocardiology
  • Journal of Translational Medicine

Leroy F. Liu's research covers key topics such as PI3K/AKT/mTOR signaling in cancer, cancer mechanisms and therapy, ubiquitin and proteasome pathways, CAR-T cell therapy research, biosimilars and bioanalytical methods, computational drug discovery methods, and biotin-related studies.

In recognition of their contributions, the scientist was named Fellow of The World Academy of Sciences in 2019.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Supercoiling of the DNA template during transcription.

    Leroy F. Liu;James C. Wang

  • Identification of the molecular basis of doxorubicin-induced cardiotoxicity

    Sui Zhang;Xiaobing Liu;Xiaobing Liu;Tasneem Bawa-Khalfe;Long Sheng Lu

  • Arrest of Replication Forks by Drug-stabilized Topoisomerase I-DNA Cleavable Complexes as a Mechanism of Cell Killing by Camptothecin

    Yaw Huei Hsiang;Michelle G. Lihou;Michelle G. Lihou;Leroy F. Liu

  • Identification of Mammalian DNA Topoisomerase I as an Intracellular Target of the Anticancer Drug Camptothecin

    Yaw Huei Hsiang;Leroy F. Liu

  • Transcription generates positively and negatively supercoiled domains in the template.

    Hai Young Wu;Shihua Shyy;James C. Wang;Leroy F. Liu

  • Cleavage of DNA by mammalian DNA topoisomerase II.

    L. F. Liu;T. C. Rowe;Liu Yang;K. M. Tewey

  • Mechanism of antitumor drug action: Poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

    Eric M. Nelson;Kathleen M. Tewey;Leroy F. Liu

  • Topoisomerase IIβ–Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane

    Yi Lisa Lyu;John E. Kerrigan;Chao-Po Lin;Anna M. Azarova

  • Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break

    Leroy-Fong Liu;Chung Cheng Liu;Bruce M. Alberts

  • Tumor Cell Death Induced by Topoisomerase-Targeting Drugs

    Tsai-Kun Li;Leroy F Liu

  • Role of Topoisomerase II in Mediating Epipodophyllotoxin-induced DNA Cleavage

    Warren Ross;Tom Rowe;Bonnie Glisson;Jack Yalowich

  • DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues

    Yaw-Huei Hsiang;Leroy F. Liu;Monroe E. Wall;Mansukh C. Wani

  • Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

    Leroy F. Liu;Kathryn G. Miller

  • Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro.

    Liu Yang;Marc S. Wold;Joachim J. Li;Thomas J. Kelly

  • Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes

    Hui Zhang;James C. Wang;Leroy F. Liu

  • Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies

    Anna M. Azarova;Yi Lisa Lyu;Chao-Po Lin;Yuan-Chin Tsai

  • Ubiquitin-dependent Destruction of Topoisomerase I Is Stimulated by the Antitumor Drug Camptothecin

    Shyamal D. Desai;Leroy F. Liu;Dolores Vazquez-Abad;Peter D'Arpa

  • Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

    Yaw Huei Hsiang;Hai Young Wu;Leroy F. Liu

  • DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

    Thomas C. Rowe;Grace L. Chen;Yaw-Huei Hsiang;Leroy F. Liu

Frequent Co-Authors

Edmond J. LaVoie
Edmond J. LaVoie Rutgers, The State University of New Jersey
Jacqueline Whang-Peng
Jacqueline Whang-Peng Taipei Medical University
Paul J. Davis
Paul J. Davis Albany Medical Center Hospital
James C. Wang
James C. Wang Harvard University
Daniel S. Pilch
Daniel S. Pilch Rutgers, The State University of New Jersey
Shaker A. Mousa
Shaker A. Mousa Albany College of Pharmacy and Health Sciences
Ting-Chao Chou
Ting-Chao Chou Memorial Sloan Kettering Cancer Center
Takashi Tsuruo
Takashi Tsuruo Japanese Foundation For Cancer Research
Bonnie S. Glisson
Bonnie S. Glisson The University of Texas MD Anderson Cancer Center
Sidney Pestka
Sidney Pestka Rutgers, The State University of New Jersey

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