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Biology and Biochemistry

D-Index
56
Citations
9243
World Ranking
14629
National Ranking
6123

Overview

Goutham Narla is affiliated with the University of Michigan-Ann Arbor in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their scholarly work encompasses 95 publications in Biochemistry, Genetics and Molecular Biology, and 57 publications in Medicine.

Their research primarily focuses on several specialized fields including:

  • Molecular Biology
  • Oncology
  • Cancer Research
  • Genetics
  • Pulmonary and Respiratory Medicine

Main topics addressed in their work include:

  • Ubiquitin and proteasome pathways
  • Peptidase Inhibition and Analysis
  • Cell death mechanisms and regulation
  • Cancer, Hypoxia, and Metabolism
  • Protein Degradation and Inhibitors
  • Biochemical and Molecular Research
  • DNA Repair Mechanisms

Narla's recent publications include the following papers:

  • "Selective PP2A Enhancement through Biased Heterotrimer Stabilization" (2020) published in Cell
  • "Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells" (2020) in Cancer Cell
  • "Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex" (2020) in PLoS Biology
  • "CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis" (2021) in Cancer Research
  • "Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers" (2020) in Journal of Biological Chemistry

Their frequent coauthors include:

  • Caitlin M. O'Connor
  • Analisa DiFeo
  • Derek J. Taylor
  • Caroline Farrington
  • Jaya Sangodkar

Common publication venues where Narla has contributed include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Journal of Clinical Investigation
  • Clinical Cancer Research

Best Publications

  • KLF6, a candidate tumor suppressor gene mutated in prostate cancer.

    Goutham Narla;Karen E. Heath;Helen L. Reeves;Dan Li

  • All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

    Jaya Sangodkar;Caroline C. Farrington;Kimberly McClinch;Matthew D. Galsky

  • microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial–mesenchymal transition

    Aditya Parikh;Christine Lee;Peronne Joseph;Sergio Marchini

  • A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.

    Goutham Narla;Analisa DiFeo;Helen L. Reeves;Daniel J. Schaid

  • Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer

    Helen L. Reeves;Helen L. Reeves;Goutham Narla;Olagunju Ogunbiyi;Asif I. Haq

  • The Kruppel-Like Factor 6 Genotype Is Associated With Fibrosis in Nonalcoholic Fatty Liver Disease

    Luca Miele;Gary Beale;Gillian Patman;Valerio Nobili

  • Krüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1

    Dan Li;Steven Yea;Side Li;Zhu Chen

  • Cyclin-Dependent Kinase Inhibition by the KLF6 Tumor Suppressor Protein through Interaction with Cyclin D1

    Sharon Benzeno;Goutham Narla;Jorge Allina;George Z. Cheng

  • Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread

    Goutham Narla;Analisa DiFeo;Shen Yao;Asoka Banno

  • Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis.

    Oonagh Dowling;Analisa Difeo;Maria C. Ramirez;Turgut Tukel;Turgut Tukel

  • Therapeutic targeting of PP2A.

    Caitlin M. O’Connor;Abbey Perl;Daniel Leonard;Jaya Sangodkar

  • Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

    Jaya Sangodkar;Abbey Perl;Rita Tohme;Janna Kiselar

  • Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.

    Sigal Kremer-Tal;Sigal Kremer-Tal;Helen L. Reeves;Helen L. Reeves;Goutham Narla;Swan N. Thung

  • The role of KLF6 and its splice variants in cancer therapy.

    Analisa DiFeo;John A. Martignetti;Goutham Narla

  • Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization *

    Dipali Date;Riku Das;Goutham Narla;Daniel I. Simon

  • PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

    Otto Kauko;Otto Kauko;Caitlin M. O’Connor;Evgeny Kulesskiy;Jaya Sangodkar

  • The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice

    Kelly A. Frazer;Goutham Narla;Jun Li Zhang;Edward M. Rubin

  • Roles of KLF6 and KLF6-SV1 in Ovarian Cancer Progression and Intraperitoneal Dissemination

    Analisa DiFeo;Goutham Narla;Jennifer Hirshfeld;Olga Camacho-Vanegas

  • KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis

    Goutham Narla;Analisa DiFeo;Yolanda Fernandez;Saravana Dhanasekaran

  • Selective PP2A Enhancement through Biased Heterotrimer Stabilization.

    Daniel Leonard;Daniel Leonard;Wei Huang;Sudeh Izadmehr;Caitlin M. O’Connor

Frequent Co-Authors

Scott L. Friedman
Scott L. Friedman Icahn School of Medicine at Mount Sinai
John A. Martignetti
John A. Martignetti Icahn School of Medicine at Mount Sinai
Jukka Westermarck
Jukka Westermarck Åbo Akademi University
Mark R. Chance
Mark R. Chance Case Western Reserve University
David L. Brautigan
David L. Brautigan University of Virginia
Josep M. Llovet
Josep M. Llovet University of Barcelona
Wenqing Xu
Wenqing Xu University of Washington
David E. Burstein
David E. Burstein Tel Aviv University
Avi Ma'ayan
Avi Ma'ayan Icahn School of Medicine at Mount Sinai
Maria R. Baer
Maria R. Baer University of Maryland, Baltimore

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