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Immunology

D-Index
83
Citations
25594
World Ranking
1438
National Ranking
732

Overview

H. Kim Lyerly is affiliated with Duke University in the United States. Their research spans multiple disciplines primarily within medicine, biochemistry, genetics and molecular biology, and immunology and microbiology. Specific subfields where they have contributed include oncology, immunology, molecular biology, cancer research, and radiology, nuclear medicine, and imaging.

The scientist's work focuses on several interconnected topics in biomedical research. These topics include:

  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • CAR-T cell therapy research
  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research

They have published extensively, with frequent contributions to several well-known journals. The primary publication venues include:

  • Cancer Research
  • Cancer Immunology Research
  • Clinical Cancer Research
  • Journal for ImmunoTherapy of Cancer
  • bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their research efforts have included Zachary C. Hartman, Michael A. Morse, Erika J. Crosby, Gangjun Lei, and Timothy N. Trotter.

Among notable recent publications authored by or including Lyerly are:

  • Exposure to low-dose ambient fine particulate matter PM2.5 and Alzheimer's disease, non-Alzheimer's dementia, and Parkinson's disease in North Carolina (2021), published in PLoS ONE
  • DC-CIK as a widely applicable cancer immunotherapy (2020), published in Expert Opinion on Biological Therapy
  • Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy (2021), published in Clinical Cancer Research
  • Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin (2020), published in Scientific Reports
  • Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio (2020), published in Journal for ImmunoTherapy of Cancer

Best Publications

  • A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

    Michael A Morse;Jennifer Garst;Takuya Osada;Shubi Khan

  • Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1

    SS Hwang;TJ Boyle;HK Lyerly;BR Cullen;BR Cullen

  • ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

    Robert Yarchoan;Kent J. Weinhold;H. Kim Lyerly;Edward Gelmann

  • Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA.

    S K Nair;D Boczkowski;M Morse;R I Cumming

  • Induction of Tumor Immunity and Cytotoxic T Lymphocyte Responses Using Dendritic Cells Transfected with Messenger RNA Amplified from Tumor Cells

    D Boczkowski;S K Nair;J H Nam;H K Lyerly

  • Migration of Human Dendritic Cells after Injection in Patients with Metastatic Malignancies

    M A Morse;R E Coleman;G Akabani;N Niehaus

  • A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-pulsed, Autologous Human Cultured Dendritic Cells in Patients with Metastatic Malignancies Expressing Carcinoembryonic Antigen

    M. A. Morse;Yuping Deng;D. Coleman;S. Hull

  • Immunotherapy of cancer with dendritic-cell-based vaccines

    E Gilboa;S K Nair;H K Lyerly

  • Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy.

    Ulrich Keilholz;Jeffrey Weber;James H. Finke;Dmitry I. Gabrilovich

  • Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

    Michael A. Morse;Amy C. Hobeika;Takuya Osada;Delila Serra

  • Use of Paravertebral Block Anesthesia in the Surgical Management of Breast Cancer: Experience in 156 Cases

    Eamonn Coveney;Christina Weltz;Roy Greengrass;J. Iglehart

  • Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead

    William H Goodson;Leroy Lowe;David O Carpenter;Michael Gilbertson

  • A review of the health impacts of barium from natural and anthropogenic exposure

    Julia Kravchenko;Thomas H. Darrah;Richard K. Miller;H. Kim Lyerly

  • The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients

    Takuya Osada;Gabriel Chong;Robert Tansik;Timothy Hong

  • Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack

    H K Lyerly;T J Matthews;A J Langlois;D P Bolognesi

  • Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion

    T J Matthews;K J Weinhold;H K Lyerly;A J Langlois

  • Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations

    Takuya Osada;Minyong Chen;Xiao Yi Yang;Ivan Spasojevic

  • The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling

    Minyong Chen;Jiangbo Wang;Jiuyi Lu;Michael C. Bond

  • Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells.

    Smita K. Nair;Michael Morse;David Boczkowski;R. Ian Cumming

  • Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.

    M H Malim;W W Freimuth;J Liu;T J Boyle

  • HIV-1 GP120-mediated immune suppression and lymphocyte destruction in the absence of viral infection.

    K J Weinhold;H K Lyerly;S D Stanley;A A Austin

  • Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA.

    Smita K. Nair;Shelley Hull;Doris Coleman;Eli Gilboa

  • Investigation of HIFU-induced anti-tumor immunity in a murine tumor model

    Zhenlin Hu;Xiao Yi Yang;Yunbo Liu;Georgy N Sankin

Frequent Co-Authors

Michael A. Morse
Michael A. Morse Duke University
Timothy M. Clay
Timothy M. Clay Duke University
Larry S. Barak
Larry S. Barak Duke University
Donna Niedzwiecki
Donna Niedzwiecki Duke University
Amy P. Abernethy
Amy P. Abernethy Duke University
Kent J. Weinhold
Kent J. Weinhold Duke University
Mary L. Disis
Mary L. Disis University of Washington
Dani P. Bolognesi
Dani P. Bolognesi Duke University
Smita Nair
Smita Nair Duke University
Andrea Amalfitano
Andrea Amalfitano Michigan State University

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Related Online Degrees & Career Pathways

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