2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
1998 - Fellow of the Royal Society of Edinburgh
His primary areas of investigation include Protein kinase A, AMPK, AMP-activated protein kinase, Biochemistry and Cell biology. His Protein kinase A research entails a greater understanding of Kinase. His studies in AMPK integrate themes in fields like Metformin, Endocrinology, Internal medicine, Skeletal muscle and Catabolism.
His AMP-activated protein kinase research integrates issues from Enzyme activator, Dephosphorylation, Cell growth and Adenosine triphosphate. His Cell biology study incorporates themes from Glycolysis, Energy homeostasis and Adenine nucleotide. His Mitogen-activated protein kinase kinase research includes themes of MAP2K7 and MAP kinase kinase kinase.
His primary scientific interests are in Protein kinase A, Biochemistry, AMPK, AMP-activated protein kinase and Cell biology. The study incorporates disciplines such as Phosphatase, Protein subunit and Adenylate kinase in addition to Protein kinase A. His research investigates the connection between Biochemistry and topics such as Molecular biology that intersect with problems in Acetyl-CoA carboxylase and Reductase.
As a part of the same scientific study, D. Grahame Hardie usually deals with the AMPK, concentrating on Internal medicine and frequently concerns with Type 2 diabetes. The concepts of his AMP-activated protein kinase study are interwoven with issues in Enzyme activator, Hypoxia, Adenosine triphosphate and Adenine nucleotide. The various areas that he examines in his Cell biology study include Allosteric regulation, Cell growth, Energy homeostasis and Metabolism.
His main research concerns AMPK, Protein kinase A, Cell biology, AMP-activated protein kinase and Phosphorylation. D. Grahame Hardie has researched AMPK in several fields, including Endocrinology, Dephosphorylation and Internal medicine. His Protein kinase A study integrates concerns from other disciplines, such as Salsalate, Catabolism, Metabolism, Aspirin and Pharmacology.
His Cell biology research incorporates themes from Glycolysis, Cancer, Oxidative phosphorylation and Cell growth. His research integrates issues of Signal transduction, Homeostasis, Energy homeostasis and Adenine nucleotide in his study of AMP-activated protein kinase. In Phosphorylation, D. Grahame Hardie works on issues like Nutrient sensing, which are connected to Growth control and Multicellular organism.
The scientist’s investigation covers issues in AMPK, AMP-activated protein kinase, Protein kinase A, Cell biology and Biochemistry. The concepts of his AMPK study are interwoven with issues in Metformin, Endocrinology, Glycolysis, Internal medicine and Energy homeostasis. His study on AMP-activated protein kinase also encompasses disciplines like
D. Grahame Hardie combines subjects such as Cancer research, Salsalate, Catabolism, Enzyme activator and Aspirin with his study of Protein kinase A. His research in Cell biology intersects with topics in Adenine nucleotide and Metabolism. D. Grahame Hardie has included themes like Molecular biology and PI3K/AKT/mTOR pathway in his Phosphorylation study.
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie;Fiona A. Ross;Simon A. Hawley.
Nature Reviews Molecular Cell Biology (2012)
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
Barbara B. Kahn;Thierry Alquier;David Carling;D. Grahame Hardie.
Cell Metabolism (2005)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
D. Grahame Hardie.
Nature Reviews Molecular Cell Biology (2007)
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
Simon A Hawley;Jérôme Boudeau;Jennifer L Reid;Kirsty J Mustard.
Journal of Biology (2003)
The AMP‐Activated Protein Kinase
D. Grahame Hardie;David Carling.
FEBS Journal (1997)
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
D G Hardie;D Carling;M Carlson.
Annual Review of Biochemistry (1998)
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
Simon A. Hawley;David A. Pan;Kirsty J. Mustard;Louise Ross.
Cell Metabolism (2005)
Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase
Simon A. Hawley;Matthew Davison;Angela Woods;Stephen P. Davies.
Journal of Biological Chemistry (1996)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
Jose M Lizcano;Olga Göransson;Rachel Toth;Maria Deak.
The EMBO Journal (2004)
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
Mhairi C. Towler;D. Grahame Hardie.
Circulation Research (2007)
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