D. Grahame Hardie

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 1998 - Fellow of the Royal Society of Edinburgh

Overview

Best Publications

• AMPK: a nutrient and energy sensor that maintains energy homeostasis

  D. Grahame Hardie;Fiona A. Ross;Simon A. Hawley

  4435
  Citations

• AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

  Barbara B. Kahn;Thierry Alquier;David Carling;D. Grahame Hardie

  3435
  Citations

• AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

  D. Grahame Hardie

  2603
  Citations

• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  Simon A Hawley;Jérôme Boudeau;Jennifer L Reid;Kirsty J Mustard

  2058
  Citations

• The AMP‐Activated Protein Kinase

  D. Grahame Hardie;David Carling

  2003
  Citations

• The mechanisms of action of metformin

  Graham Rena;D. Grahame Hardie;Ewan R. Pearson

  1938
  Citations

• Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

  Simon A. Hawley;David A. Pan;Kirsty J. Mustard;Louise Ross

  1934
  Citations

• Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

  Simon A. Hawley;Matthew Davison;Angela Woods;Stephen P. Davies

  1775
  Citations

• AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function

  D. Grahame Hardie

  1716
  Citations

• AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

  Mhairi C. Towler;D. Grahame Hardie

  1578
  Citations

• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

  Jose M Lizcano;Olga Göransson;Rachel Toth;Maria Deak

  1558
  Citations

• The AMP-activated protein kinase pathway – new players upstream and downstream

  D. Grahame Hardie

  1429
  Citations

• 5‐Aminoimidazole‐4‐Carboxamide Ribonucleoside

  Julia M. Corton;John G. Gillespie;Simon A. Hawley;D. Grahame Hardie

  1341
  Citations

• Metabolism of inflammation limited by AMPK and pseudo-starvation

  Luke A. J. O'Neill;D. Grahame Hardie

  1259
  Citations

• Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

  D. Grahame Hardie

  1248
  Citations

• Management of cellular energy by the AMP-activated protein kinase system.

  D.Grahame Hardie;John W Scott;David A Pan;Emma R Hudson

  1051
  Citations

• AMP-activated protein kinase--development of the energy sensor concept.

  D. Grahame Hardie;Simon A. Hawley;John W. Scott

  1014
  Citations

• Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

  T. A. J. Haystead;A. T. R. Sim;D. Carling;R. C. Honnor

  1000
  Citations

• AMP-activated protein kinase: the energy charge hypothesis revisited.

  D. Grahame Hardie;Simon A. Hawley

  976
  Citations

• AMPK: Sensing Glucose as well as Cellular Energy Status

  Sheng-Cai Lin;D. Grahame Hardie

  948
  Citations