Simon A. Hawley

Overview

Best Publications

• AMPK: a nutrient and energy sensor that maintains energy homeostasis

  D. Grahame Hardie;Fiona A. Ross;Simon A. Hawley

  4435
  Citations

• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  Simon A Hawley;Jérôme Boudeau;Jennifer L Reid;Kirsty J Mustard

  2058
  Citations

• Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

  Simon A. Hawley;David A. Pan;Kirsty J. Mustard;Louise Ross

  1934
  Citations

• Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

  Simon A. Hawley;Matthew Davison;Angela Woods;Stephen P. Davies

  1775
  Citations

• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

  Jose M Lizcano;Olga Göransson;Rachel Toth;Maria Deak

  1558
  Citations

• 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

  J M Corton;J G Gillespie;S A Hawley;D G Hardie

  1492
  Citations

• 5‐Aminoimidazole‐4‐Carboxamide Ribonucleoside

  Julia M. Corton;John G. Gillespie;Simon A. Hawley;D. Grahame Hardie

  1341
  Citations

• AMP-activated protein kinase--development of the energy sensor concept.

  D. Grahame Hardie;Simon A. Hawley;John W. Scott

  1014
  Citations

• AMP-activated protein kinase: the energy charge hypothesis revisited.

  D. Grahame Hardie;Simon A. Hawley

  976
  Citations

• The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism

  Simon A. Hawley;Anne E. Gadalla;Grith Skytte Olsen;D. Grahame Hardie

  941
  Citations

• CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

  John W. Scott;Simon A. Hawley;Kevin A. Green;Miliea Anis

  902
  Citations

• Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

  Simon A. Hawley;Fiona A. Ross;Cyrille Chevtzoff;Kevin A. Green

  892
  Citations

• The ancient drug salicylate directly activates AMP-activated protein kinase

  Simon A. Hawley;Morgan D. Fullerton;Fiona A. Ross;Jonathan D. Schertzer

  813
  Citations

• Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

  Chen-Song Zhang;Simon A. Hawley;Yue Zong;Mengqi Li

  714
  Citations

• 5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

  S A Hawley;M A Selbert;E G Goldstein;A M Edelman

  633
  Citations

• AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

  Graeme J. Gowans;Simon A. Hawley;Fiona A. Ross;D. Grahame Hardie

  607
  Citations

• Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

  Richard M. Reznick;Haihong Zong;Ji Li;Katsutaro Morino

  596
  Citations

• Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase

  Blerina Kola;Erika Hubina;Sonia A. Tucci;Tim C. Kirkham

  592
  Citations

• AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

  I Salt;J W Celler;S A Hawley;A Prescott

  536
  Citations

• Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

  Olga Göransson;Andrew McBride;Simon A. Hawley;Fiona A. Ross

  498
  Citations