Calum Sutherland

Overview

Best Publications

• Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.

  Calum Sutherland;I A Leighton;P Cohen

  1290
  Citations

• Filaggrin in the frontline: role in skin barrier function and disease.

  Aileen Sandilands;Calum Sutherland;Alan D. Irvine;Alan D. Irvine;W. H. Irwin McLean

  1005
  Citations

• Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

  Sudhir Chowdhry;Yiguo Zhang;Michael McMahon;Calum Sutherland

  634
  Citations

• 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

  P A Lochhead;I P Salt;K S Walker;D G Hardie

  521
  Citations

• Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

  K. Zhou;K. Zhou;C. Bellenguez;C.C.A. Spencer;A.J. Bennett

  491
  Citations

• Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

  Eva Kickstein;Sybille Krauss;Sybille Krauss;Paul Thornhill;Désirée Rutschow

  468
  Citations

• What Are the bona fide GSK3 Substrates

  Calum Sutherland

  411
  Citations

• The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro

  Calum Sutherland;Philip Cohen

  315
  Citations

• GSK-3 Phosphorylation of the Alzheimer Epitope within Collapsin Response Mediator Proteins Regulates Axon Elongation in Primary Neurons

  Adam R. Cole;Axel Knebel;Nick A. Morrice;Laura A. Robertson

  301
  Citations

• Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

  Pamela A. Lochhead;Matthew Coghlan;Simon Q.J. Rice;Calum Sutherland

  294
  Citations

• Distinct Priming Kinases Contribute to Differential Regulation of Collapsin Response Mediator Proteins by Glycogen Synthase Kinase-3 in Vivo

  Adam R. Cole;Frédéric Causeret;Gokhan Yadirgi;C. James Hastie

  253
  Citations

• Molecular connexions between dementia and diabetes

  Adam R. Cole;Arlene Astell;Charlotte Green;Calum Sutherland

  220
  Citations

• Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.

  Calum Sutherland;Janine Alterio;David G. Campbell;Béatrice Le Bourdellès

  215
  Citations

• Phosphatidylinositol 3-Kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin: dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression

  Calum Sutherland;Richard M. O'Brien;Daryl K. Granner

  211
  Citations

• Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.

  Kaixin Zhou;Sook Wah Yee;Eric L Seiser;Nienke van Leeuwen

  209
  Citations

• Collapsin response mediator protein‐2 hyperphosphorylation is an early event in Alzheimer’s disease progression

  Adam R. Cole;Wendy Noble;Lidy Van Aalten;Florian Plattner

  206
  Citations

• Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

  Emma L Clayton;Nancy Sue;Karen J Smillie;Timothy O'Leary

  193
  Citations

• Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation.

  Shirin Mirshamsi;Hilary A Laidlaw;Ke Ning;Erin Anderson

  191
  Citations

• The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

  Kashyap Patel;Marc Foretz;Allison Marion;David G. Campbell

  179
  Citations

• Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway

  Robert A. Gabbay;Calum Sutherland;Luigi Gnudi;Barbara B. Kahn

  179
  Citations