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Biology and Biochemistry

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78
Citations
32505
World Ranking
4453
National Ranking
336

Medicine

D-Index
78
Citations
32664
World Ranking
17833
National Ranking
1621

Research.com Recognitions

  • 2013 - Fellow of the Royal Society, United Kingdom
  • 2005 - Fellow of the Royal Society of Edinburgh
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

John Savill is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily focuses on Immunology and Microbiology, with significant contributions also made in Medicine. The main subfields of their work include Immunology, Oncology, and Pulmonary and Respiratory Medicine.

Their research addresses several key topics, notably:

  • Phagocytosis and Immune Regulation
  • Immune cells in cancer
  • Immunotherapy and Immune Responses
  • Biomarkers in Disease Mechanisms
  • Lung Cancer Treatments and Mutations
  • Cancer Treatment and Pharmacology
  • HER2/EGFR in Cancer Research

John Savill has contributed to multiple peer-reviewed publications, frequently publishing in venues such as the American Journal Of Pathology, PLoS ONE, bioRxiv (Cold Spring Harbor Laboratory), and Annals of Oncology. Selected recent papers include:

  • "Apoptotic Cell-Directed Resolution of Lung Inflammation Requires Myeloid αv Integrin-Mediated Induction of Regulatory T Lymphocytes," 2020, American Journal Of Pathology
  • "Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation," 2020, PLoS ONE
  • "Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Table of Contents," 2020, American Journal Of Pathology
  • "1877P Adverse effects (AEs) of trastuzumab deruxtecan (T-DXd) in solid tumours: A meta-analysis," 2024, Annals of Oncology

Collaborations are a notable aspect of their work, with frequent co-authors including:

  • Ailiang Zhang
  • Adam Lacy-Hulbert
  • Stephen M. Anderton
  • Christopher Haslett
  • Helena Païdassi

John Savill has received recognition through several fellowships, including Fellowship of the Royal Society of Edinburgh awarded in 2005, Fellowship of the Royal Society in the United Kingdom awarded in 2013, and Fellowship of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • Resolution of inflammation: the beginning programs the end.

    Charles N Serhan;John Savill

  • Corpse clearance defines the meaning of cell death

    John Savill;Valerie Fadok

  • Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

    John S Savill;Andrew H. Wyllie;Janet E Henson;Mark J Walport

  • A blast from the past: clearance of apoptotic cells regulates immune responses

    John Savill;Ian Dransfield;Chris Gregory;Chris Haslett

  • Phagocyte recognition of cells undergoing apoptosis

    John Savill;Valerie Fadok;Peter Henson;Chris Haslett

  • Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis.

    John Savill;Ian Dransfield;Nancy Hogg;Christopher Haslett

  • Apoptosis in resolution of inflammation.

    J Savill

  • Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

    John Savill;Nancy Hogg;Yi Ren;Christopher Haslett

  • A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo.

    Philip R. Taylor;Anna Carugati;Valerie A. Fadok;H. Terence Cook

  • Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

    V A Fadok;J S Savill;C Haslett;D L Bratton

  • Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis.

    Adriano G Rossi;Deborah A Sawatzky;Annemieke Walker;Carol Ward

  • Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment.

    Simon Brown;Isabelle Heinisch;Ewan Ross;Kate Shaw

  • Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis.

    Amanda J. Baker;Andrew Mooney;Jeremy Hughes;Donna Lombardi

  • CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.

    Yi Ren;Roy L. Silverstein;Janet Allen;John Savill

  • Recognition and phagocytosis of cells undergoing apoptosis

    John Savill

  • Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression.

    I Dransfield;A M Buckle;J S Savill;A McDowall

  • Apoptosis: The importance of being eaten

    Yi Ren;John Savill

  • Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism.

    John Savill;P M Henson;Christopher Haslett

  • Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2.

    Laura C. Meagher;John S. Savill;Amanda Baker;Richard W. Fuller

  • Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5.

    M Stern;L Meagher;J Savill;C Haslett

Frequent Co-Authors

Christopher Haslett
Christopher Haslett University of Edinburgh
Jonathan R. Seckl
Jonathan R. Seckl University of Edinburgh
Ian Dransfield
Ian Dransfield University of Edinburgh
Peter M. Henson
Peter M. Henson National Jewish Health
Adriano G. Rossi
Adriano G. Rossi University of Edinburgh
David A. Gray
David A. Gray University of Nottingham
Roy L. Silverstein
Roy L. Silverstein Medical College of Wisconsin
Valerie A. Fadok
Valerie A. Fadok Zoetis (United States)
Charles D. Pusey
Charles D. Pusey Imperial College London

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