World's Best Scientists 2026 revealed!
Shigekazu Nagata

Shigekazu Nagata

Award Badge
Molecular Biology
Japan
2026
Award Badge
Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Molecular Biology

D-Index
144
Citations
121262
World Ranking
102
National Ranking
7

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Japan Leader Award
  • 2025 - Research.com Molecular Biology in Japan Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Japan Leader Award
  • 2023 - Research.com Molecular Biology in Japan Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Japan Leader Award
  • 2015 - Member of the National Academy of Sciences
  • 2013 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • 1995 - Robert Koch Prize

Overview

Shigekazu Nagata is affiliated with Osaka University in Japan and conducts research primarily in the fields of biochemistry, genetics, molecular biology, medicine, and immunology. Their work spans subfields including molecular biology, immunology, physiology, cell biology, and immunology and allergy.

Their research focuses on several main topics:

  • Lipid Membrane Structure and Behavior
  • Erythrocyte Function and Pathophysiology
  • Phagocytosis and Immune Regulation
  • Endoplasmic Reticulum Stress and Disease
  • Cellular Transport and Secretion
  • Cell Adhesion Molecules Research
  • ATP Synthase and ATPases Research

Their recent papers include:

  • "Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases," 2023, published in Nature Reviews Molecular Cell Biology
  • "Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM," 2020, Cell Reports
  • "Crystal structure of a human plasma membrane phospholipid flippase," 2020, Journal of Biological Chemistry
  • "Sensing and clearance of apoptotic cells," 2020, Current Opinion in Immunology
  • "Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells," 2022, Proceedings of the National Academy of Sciences

Frequent coauthors in their work are:

  • Katsumori Segawa
  • Takaharu Sakuragi
  • R. Kanai
  • Masahide Kikkawa
  • Chikashi Toyoshima

Common publication venues for their research outputs include:

  • Proceedings of the National Academy of Sciences
  • Nature Structural & Molecular Biology
  • Journal of Biological Chemistry
  • Nature Reviews Molecular Cell Biology
  • Cell Reports

The scientist has received several awards, including membership in the National Academy of Sciences in 2015, the Keio Medical Science Prize from Keio University in Tokyo in 2013, and the Robert Koch Prize in 1995.

Best Publications

  • Apoptosis by death factor.

    Shigekazu Nagata

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • The Fas Death Factor

    Shigekazu Nagata;Pierre Golstein

  • A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

    Masato Enari;Hideki Sakahira;Hideki Yokoyama;Katsuya Okawa

  • The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.

    Naoto Itoh;Shin Yonehara;Ai Ishii;Minako Yonehara

  • Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

    Takashi Suda;Tomohiro Takahashi;Pierre Golstein;Pierre Golstein;Shigekazu Nagata

  • Lethal effect of the anti-Fas antibody in mice

    Jun Ogasawara;Rie Watanabe-Fukunaga;Masashi Adachi;Akio Matsuzawa

  • Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

    Hideki Sakahira;Masato Enari;Shigekazu Nagata;Shigekazu Nagata

  • Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

    David Kägi;Françoise Vignaux;Birgit Ledermann;Kurt Bürki

  • pEF-BOS, a powerful mammalian expression vector.

    Seiichi Mizushima;Shigekazu Nagata

  • Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

    Tomohiro Takahashi;Masato Tanaka;Camllynn I. Brannan;Nancy A. Jenkins

  • Identification of a factor that links apoptotic cells to phagocytes

    Rikinari Hanayama;Masato Tanaka;Keiko Miwa;Azusa Shinohara

  • Identification of Tim4 as a phosphatidylserine receptor.

    Masanori Miyanishi;Masanori Miyanishi;Kazutoshi Tada;Masato Koike;Yasuo Uchiyama

  • APOPTOTIC DNA FRAGMENTATION

    Shigekazu Nagata

  • Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

    Masato Enari;Robert V. Talanian;Winnie W. Wong;Shigekazu Nagata

  • A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen.

    Naoto Itoh;Shigekazu Nagata

  • Fas and Fas ligand: lpr and gld mutations

    Shigekazu Nagata;Takashi Suda

  • Fas ligand-induced apoptosis.

    Shigekazu Nagata

  • Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor.

    Shigekazu Nagata;Masayuki Tsuchiya;Shigetaka Asano;Yoshito Kaziro

  • Involvement of an ICE-like protease in Fas-mediated apoptosis

    Masato Enari;Hubert Hug;Shigekazu Nagata

Frequent Co-Authors

Masato Tanaka
Masato Tanaka Tokyo University of Pharmacy and Life Sciences
Takashi Suda
Takashi Suda Kanazawa University
Yoshito Kaziro
Yoshito Kaziro Kyoto University
Yasuo Uchiyama
Yasuo Uchiyama Juntendo University
Pierre Golstein
Pierre Golstein Aix-Marseille University
Charles Weissmann
Charles Weissmann University of Florida
Hitoshi Hashimoto
Hitoshi Hashimoto Osaka University
Shin Yonehara
Shin Yonehara Kyoto University
Kensaku Mori
Kensaku Mori University of Tokyo
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

If you are considering a future in Molecular Biology, there are many online educational routes and related career pathways to explore in the USA. Flexibility and accessibility are key benefits of online degrees, especially for working professionals or students transitioning between fields.

For those interested in laboratory or data management, pursuing the cheapest library science degree online can open doors to roles in scientific libraries and research organizations. If healthcare appeals to you, the expanding field of speech-language pathology offers options such as asha accredited online slp master's programs, as well as speech pathology bridge programs online for students transitioning from unrelated majors.

Healthcare careers outside of molecular specialties are also an option. If you have a non-nursing bachelor’s degree, you can fast-track into nursing with non nursing degree to bsn online programs. Exploring these affordable and accelerated online programs can help you match your interests with emerging workforce needs across science, healthcare, and research sectors.

Best Scientists Citing Shigekazu Nagata

Trending Scientists

Recently Published Articles