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Biology and Biochemistry

D-Index
87
Citations
25585
World Ranking
2851
National Ranking
1464

Overview

Andrei V. Gudkov is affiliated with the Roswell Park Cancer Institute in the United States. Their primary fields of study encompass Biochemistry, Genetics and Molecular Biology, with 54 publications, and Medicine, represented by 41 publications. The subfields most frequently addressed in their work include Molecular Biology, Immunology, Oncology, Plant Science, and Genetics.

The main topics covered in their research feature Histone Deacetylase Inhibitors Research, Immunotherapy and Immune Responses, Immune Response and Inflammation, Chromosomal and Genetic Variations, Genetics, Aging, and Longevity in Model Organisms, Epigenetics and DNA Methylation, and Cancer, Hypoxia, and Metabolism.

Research outputs by Gudkov include several notable papers:

  • Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit (2021), published in Nature Communications
  • OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis (2020), published in Leukemia
  • Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG (2021), published in Cell Reports
  • Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue (2020), published in Aging Cell
  • A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications (2021), published in Communications Biology

Gudkov frequently publishes in several scientific venues, including Proceedings of the National Academy of Sciences, bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Doklady Earth Sciences, and Nature Communications.

The scientist has collaborated extensively with other researchers. Their frequent co-authors include Katerina V. Gurova, Anatoli S. Gleiberman, Murray D. Norris, Michelle Haber, and Ekaterina L. Andrianova.

Best Publications

  • A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.

    Pavel G. Komarov;Elena A. Komarova;Roman V. Kondratov;Konstantin Christov-Tselkov

  • An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.

    Lyudmila G. Burdelya;Vadim I. Krivokrysenko;Thomas C. Tallant;Evguenia Strom

  • The role of p53 in determining sensitivity to radiotherapy

    Andrei V. Gudkov;Elena A. Komarova

  • Structural Basis of TLR5-Flagellin Recognition and Signaling

    Sung-il Yoon;Oleg Kurnasov;Venkatesh Natarajan;Minsun Hong

  • Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation

    Igor Garkavtsev;Alexander Kazarov;Andrei Gudkov;Karl Riabowol

  • The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control

    Igor Garkavtsev;Irina A. Grigorian;Valeria S. Ossovskaya;Valeria S. Ossovskaya;Mikhail V. Chernov

  • Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

    Sarah S. Bacus;Andrei V. Gudkov;Michael Lowe;Ljuba Lyass

  • Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

    Andrei V Budanov;Tzipora Shoshani;Alexander Faerman;Elena Zelin

  • Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

    Evguenia Strom;Swati Sathe;Pavel G Komarov;Olga B Chernova

  • LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

    Matthew Simon;Michael Van Meter;Julia Ablaeva;Zhonghe Ke

  • Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

    Elena A. Komarova;Mikhail V. Chernov;Roberta Franks;Kaihua Wang

  • Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

    Brandon M. Hall;Vitaly Balan;Anatoli S. Gleiberman;Evguenia Strom

  • Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65

    Tao Lu;Mark W Jackson;Benlian Wang;Maojing Yang

  • Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription

    Mary L. Spengler;Karen K. Kuropatwinski;Maria Comas;Alexander V. Gasparian

  • p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

    Brandon M Hall;Vitaly Balan;Anatoli S Gleiberman;Evguenia Strom

  • The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

    Lioubov G. Korotchkina;Olga V. Leontieva;Elena I. Bukreeva;Zoya N. Demidenko

  • Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

    Victoria Y. Gorbacheva;Roman V. Kondratov;Renliang Zhang;Srujana Cherukuri

  • Paradoxical suppression of cellular senescence by p53

    Zoya N. Demidenko;Lioubov G. Korotchkina;Andrei V. Gudkov;Mikhail V. Blagosklonny

  • Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors

    Katerina V. Gurova;Jason E. Hill;Canhui Guo;Anatoly Prokvolit

  • Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

    Xiaodong Fang;Eviatar Nevo;Lijuan Han;Erez Y. Levanon

Frequent Co-Authors

Igor B. Roninson
Igor B. Roninson University of South Carolina
Mikhail V. Blagosklonny
Mikhail V. Blagosklonny Roswell Park Cancer Institute
Robert L. Fairchild
Robert L. Fairchild Cleveland Clinic Lerner College of Medicine
George R. Stark
George R. Stark Cleveland Clinic
Andrei L. Osterman
Andrei L. Osterman Discovery Institute
Andrei Seluanov
Andrei Seluanov University of Rochester
Vera Gorbunova
Vera Gorbunova University of Rochester
Amiya K. Banerjee
Amiya K. Banerjee Cleveland Clinic Foundation
Vadim N. Gladyshev
Vadim N. Gladyshev Brigham and Women's Hospital
Vijay K. Singh
Vijay K. Singh Uniformed Services University of the Health Sciences

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