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Chemistry

D-Index
57
Citations
11220
World Ranking
11115
National Ranking
3034

Overview

C. Fred Brewer is affiliated with the Albert Einstein College of Medicine in the United States. Their research spans several interconnected fields, primarily within biochemistry, genetics, molecular biology, immunology, microbiology, and medicine. Their work dives deeply into molecular biology and immunology, with significant contributions also linked to organic chemistry, public health, environmental and occupational health, and radiology, nuclear medicine, and imaging.

The scientist's recent scholarly output includes a number of publications focused on carbohydrate chemistry and biochemistry as well as reproductive health. Notably, these publications include:

  • Multivalent lectin-carbohydrate interactions: Energetics and mechanisms of binding (2023) published in Advances in carbohydrate chemistry and biochemistry
  • Mechanism of Mucin Recognition by Lectins: A Thermodynamic Study (2022) published in Methods in molecular biology
  • Mechanism of multivalent glycoconjugate-lectin interaction: An update (2023) published in Advances in carbohydrate chemistry and biochemistry
  • Understanding sexual and reproductive healthcare-seeking behaviors of college students at University of California's on-campus health clinic (2025) published in Journal of American College Health

Frequent publication venues for Brewer include:

  • Advances in carbohydrate chemistry and biochemistry
  • Methods in molecular biology
  • Journal of American College Health

Their research concentrates on topics such as glycosylation and glycoproteins, galectins and cancer biology, carbohydrate chemistry and synthesis, as well as monoclonal and polyclonal antibodies. Brewer has also contributed to adolescent sexual and reproductive health, reproductive health and contraception, and issues regarding female genital mutilation/cutting.

Notable coauthors in Brewer's research include Tarun K. Dam, who has collaborated on multiple recent papers, Jared L. Edwards, Priyanka D. Kadav, Purnima Bandyopadhyay, and Olivia Hohman. These collaborations suggest a strong interdisciplinary approach, particularly in the biochemical and molecular aspects of lectin and carbohydrate research, alongside public health matters.

Best Publications

  • Galectin-3 Precipitates as a Pentamer with Synthetic Multivalent Carbohydrates and Forms Heterogeneous Cross-linked Complexes

    Nisar Ahmad;Hans J. Gabius;Sabine André;Herbert Kaltner

  • Thermodynamic studies of lectin-carbohydrate interactions by isothermal titration calorimetry.

    Tarun K. Dam;C. Fred Brewer

  • Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death.

    Brianna N. Stillman;Daniel K. Hsu;Mabel Pang;C. Fred Brewer

  • Clusters, bundles, arrays and lattices: novel mechanisms for lectin–saccharide-mediated cellular interactions

    C.Fred Brewer;M.Carrie Miceli;Linda G Baum

  • Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction.

    J C Sacchettini;L G Baum;C F Brewer

  • Lectins as Pattern Recognition Molecules: The Effects of Epitope Density in Innate Immunity#

    Tarun K. Dam;C. Fred Brewer

  • Galectins bind to the multivalent glycoprotein asialofetuin with enhanced affinities and a gradient of decreasing binding constants.

    Tarun K. Dam;Hans J. Gabius;Sabine André;Herbert Kaltner

  • Binding of multivalent carbohydrates to concanavalin A and Dioclea grandiflora lectin. Thermodynamic analysis of the "multivalency effect".

    Tarun K. Dam;René Roy;Sanjoy K. Das;Stefan Oscarson

  • Thermodynamics of lectin-carbohydrate interactions. Titration microcalorimetry measurements of the binding of N-linked carbohydrates and ovalbumin to concanavalin A.

    Unknown

  • Effects of Clustered Epitopes in Multivalent Ligand−Receptor Interactions†

    Tarun K. Dam;C. Fred Brewer

  • Conformation states of concanavalin A: Kinetics of transitions induced by interaction with Mn2+ and Ca2+

    Rodney D. Brown;C. Fred Brewer;Seymour H. Koenig

  • Evidence for possible nonspecific reactions between N-ethylmaleimide and proteins☆

    Unknown

  • Binding and cross-linking properties of galectins.

    C Fred Brewer

  • X-ray crystal structure of the soybean agglutinin cross-linked with a biantennary analog of the blood group I carbohydrate antigen

    A Dessen;D Gupta;S Sabesan;C F Brewer

  • Thermodynamic binding studies of bivalent oligosaccharides to galectin-1, galectin-3, and the carbohydrate recognition domain of galectin-3.

    Nisar Ahmad;Hans J. Gabius;Subramanian Sabesan;Stefan Oscarson

  • Thermodynamic binding studies of cell surface carbohydrate epitopes to galectins-1, -3, and -7: Evidence for differential binding specificities

    Nisar Ahmad;Hans J. Gabius;Herbert Kaltner;Sabine André

  • Magnetic field dependence of solvent proton relaxation induced by Gd3+ and Mn2+ complexes

    Seymour H. Koenig;Coral Baglin;Rodney D. Brown;C. Fred Brewer

  • X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.

    L.R. Olsen;A. Dessen;A. Dessen;D. Gupta;D. Gupta;S. Sabesan

  • Multivalent lectin-carbohydrate interactions energetics and mechanisms of binding.

    Tarun K. Dam;C. Fred Brewer

  • Thermodynamics of multivalent carbohydrate-lectin cross-linking interactions: importance of entropy in the bind and jump mechanism

    Tarun K. Dam;Thomas A. Gerken;C. Fred Brewer

  • Negative cooperativity associated with binding of multivalent carbohydrates to lectins. Thermodynamic analysis of the "multivalency effect".

    Tarun K. Dam;René Roy;Daniel Pagé;C. Fred Brewer

  • Interactions of saccharides with concanavalin A. Mechanism of binding of alpha- and beta-methyl D-glucopyranoside to concanavalin A as determined by 13C nuclear magnetic resonance.

    C. F. Brewer;H. Sternlicht;D. M. Marcus;A. P. Grollman

Frequent Co-Authors

Stefan Oscarson
Stefan Oscarson University College Dublin
Seymour H. Koenig
Seymour H. Koenig IBM (United States)
René Roy
René Roy University of Quebec at Montreal
Bjørn T. Stokke
Bjørn T. Stokke Norwegian University of Science and Technology
Benildo Sousa Cavada
Benildo Sousa Cavada Universidade Federal do Ceará
Herbert Kaltner
Herbert Kaltner Ludwig-Maximilians-Universität München
Hans-Joachim Gabius
Hans-Joachim Gabius Ludwig-Maximilians-Universität München
James C. Sacchettini
James C. Sacchettini Texas A&M University
Joy M. Burchell
Joy M. Burchell King's College London
Fu-Tong Liu
Fu-Tong Liu Academia Sinica

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