World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
84
Citations
38853
World Ranking
862
National Ranking
454

Overview

Igor B. Roninson is affiliated with the University of South Carolina in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable focus on several subfields including Molecular Biology, Pulmonary and Respiratory Medicine, Oncology, Genetics, and Immunology.

Their work covers a range of main topics, notably in:

  • Advanced Breast Cancer Therapies
  • Ubiquitin and proteasome pathways
  • Epigenetics and DNA Methylation
  • Prostate Cancer Treatment and Research
  • CRISPR and Genetic Engineering
  • Protein Degradation and Inhibitors
  • Chronic Lymphocytic Leukemia Research

Igor B. Roninson has contributed extensively to the scientific literature, with frequent publications in venues such as Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, eLife, and Atherosclerosis.

Frequent co-authors collaborating with Roninson include:

  • Mengqian Chen
  • Eugenia V. Broude
  • Jing Li
  • Victor V. Tatarskiy
  • Xiaokai Ding

Notable recent publications authored or co-authored by Igor B. Roninson include:

  • CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins, 2023, Nucleic Acids Research
  • Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo, 2022, Proceedings of the National Academy of Sciences
  • The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs, 2021, Cells
  • A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics, 2022, Journal of Medicinal Chemistry
  • Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types, 2021, Cancers

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

    Chang jie Chen;Janice E. Chin;Kazumitsu Ueda;Douglas P. Clark

  • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

    Preet M. Chaudhary;Igor B. Roninson

  • Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

    William S. Chen;Pei Zhang Xu;Kathrin Gottlob;Mei Ling Chen

  • Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

    K. E. Noonan;C. Beck;T. A. Holzmayer;J. E. Chin

  • If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.

    Igor B. Roninson;Eugenia V. Broude;Bey-Dih Chang

  • Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

    Igor B. Roninson;Janice E. Chin;Kyunghee Choi;Philippe Gros

  • Tumor Cell Senescence in Cancer Treatment

    Igor B Roninson

  • Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

    D.-W. Shen;A. Fojo;J. E. Chin;I. B. Roninson

  • A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

    Bey-Dih Chang;Eugenia V. Broude;Milos Dokmanovic;Hongming Zhu

  • Hallmarks of senescence in carcinogenesis and cancer therapy.

    Jerry W Shay;Igor B Roninson

  • Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases.

    Bey Dih Chang;Keiko Watanabe;Eugenia V. Broude;Jing Fang

  • The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

    Kazumitsu Ueda;Marilyn M. Cornwell;Michael M. Gottesman;Ira Pastan

  • Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts

    Igor B Roninson

  • An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.

    Kyunghee Choi;Chang jie Chen;Michael Kriegler;Igor B. Roninson

  • The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

    K. Ueda;D. P. Clark;Chang-Jie Chen;I. B. Roninson

  • Methods to Detect P-Glycoprotein-associated Multidrug Resistance in Patients' Tumors: Consensus Recommendations

    William T. Beck;Thomas M. Grogan;Cheryl L. Willman;Carlos Cordon-Cardo

  • Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

    PM Chaudhary;EB Mechetner;IB Roninson

  • Induction of Multidrug Resistance in Human Cells by Transient Exposure to Different Chemotherapeutic Drugs

    Preet M. Chaudhary;Igor B. Roninson

  • Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody

    Eugene B. Mechetner;Igor B. Roninson

Frequent Co-Authors

Andrei V. Gudkov
Andrei V. Gudkov Roswell Park Cancer Institute
Ira Pastan
Ira Pastan Center for Cancer Research
Michael M. Gottesman
Michael M. Gottesman National Institutes of Health
Wilfred D. Stein
Wilfred D. Stein Hebrew University of Jerusalem
Dale E. Bredesen
Dale E. Bredesen University of California, Los Angeles
Kazumitsu Ueda
Kazumitsu Ueda Kyoto University
Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Stefano Salvioli
Stefano Salvioli University of Bologna
Konstantin Chumakov
Konstantin Chumakov US Food and Drug Administration

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Molecular Biology in the USA opens the door to several flexible online degree options and diverse career paths, especially in nursing and health sciences. Many students with a background in biology seek accelerated nursing credentials, such as the fastest rn to bsn program online. These programs allow students to earn qualifications quickly and begin a rewarding healthcare career.

For those aiming to build advanced expertise or transition into nursing from another field, direct entry msn programs offer pathways to a Master of Science in Nursing, even for non-nurses. Ambitious professionals may also consider rn to np programs online as a way to become nurse practitioners through efficient bridge curricula.

When researching program options, accreditation is crucial for future licensure and employment. Compare the standards at various institutions, such as Capella University, by reviewing issues like capella university nursing accreditation.

Whether you’re advancing a biology career or transitioning into healthcare, understanding these pathways will help you make informed educational choices.

Best Scientists Citing Igor B. Roninson

Trending Scientists