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Overview

Thomas Efferth is affiliated with Johannes Gutenberg University of Mainz in Germany. Their research spans across several main fields including Medicine and Biochemistry, Genetics and Molecular Biology, with extensive contributions to subfields such as Molecular Biology, Pharmacology, Oncology, Complementary and Alternative Medicine, and Plant Science.

The scientist's work covers a variety of topics, notably:

  • Natural product bioactivities and synthesis
  • Drug transport and resistance mechanisms
  • Computational drug discovery methods
  • Pharmacological effects of natural compounds
  • Cancer therapeutics and mechanisms
  • Medicinal plants and bioactive compounds
  • Histone deacetylase inhibitors research

Thomas Efferth has published in multiple venues, with frequent publications in:

  • Phytomedicine
  • Molecules
  • The Cambridge Structural Database
  • Pharmaceuticals
  • Journal of Ethnopharmacology

Recent notable papers include:

  • "Natural products in drug discovery: advances and opportunities" (2021, Nature Reviews Drug Discovery)
  • "Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance" (2020, Drug Resistance Updates)
  • "Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases" (2020, Medicinal Research Reviews)
  • "Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis" (2020, Phytomedicine)
  • "The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases" (2021, Medicinal Research Reviews)

The scientist frequently collaborates with coauthors including Mona Dawood, Mohamed-Elamir F. Hegazy, Mohamed E.M. Saeed, Sara Abdelfatah, and Sabine M. Klauck.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Natural products in drug discovery: advances and opportunities.

    Atanas G Atanasov;Sergey B Zotchev;Verena M Dirsch

  • The anti-malarial artesunate is also active against cancer

    Thomas Efferth;Heather Dunstan;Axel Sauerbrey;Hayato Miyachi

  • From traditional Chinese medicine to rational cancer therapy

    Thomas Efferth;Paul C.H. Li;Venkata S. Badireenath Konkimalla;Bernd Kaina

  • Antimicrobial activity of clove and rosemary essential oils alone and in combination

    YuJie Fu;YuanGang Zu;LiYan Chen;XiaoGuang Shi

  • Molecular Modes of Action of Artesunate in Tumor Cell Lines

    Thomas Efferth;Axel Sauerbrey;Armin Olbrich;Erich Gebhart

  • The Antiviral Activities of Artemisinin and Artesunate

    Thomas Efferth;Marta R. Romero;Marta R. Romero;Dana G. Wolf;Thomas Stamminger

  • Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy.

    Thomas Efferth;Egon Koch

  • From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.

    Thomas Efferth

  • The role of p53 in cancer drug resistance and targeted chemotherapy

    Karin Hientz;André Mohr;Dipita Bhakta-Guha;Thomas Efferth

  • Best practice in research - Overcoming common challenges in phytopharmacological research

    Michael Heinrich;Giovanni Appendino;Thomas Efferth;Robert Fürst

  • Chemotherapy-induced resistance by ATP-binding cassette transporter genes.

    Jean-Pierre Gillet;Thomas Efferth;José Remacle

  • Activities of Ten Essential Oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 Cancer Cells

    Yuangang Zu;Huimin Yu;Lu Liang;Yujie Fu

  • Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron.

    Thomas Efferth;Achille Benakis;Marta R. Romero;Maja Tomicic

  • Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells.

    Thomas Efferth

  • Molecular principles of cancer invasion and metastasis (review).

    Mathias Felix Leber;Thomas Efferth

  • Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance

    Nuray Erin;Jelena Grahovac;Anamaria Brozovic;Thomas Efferth

  • Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells.

    Edna Ooko;Mohamed E.M. Saeed;Onat Kadioglu;Shabnam Sarvi

  • Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system.

    Marta R. Romero;Thomas Efferth;Maria A. Serrano;Beatriz Castaño

  • Willmar Schwabe Award 2006: Antiplasmodial and Antitumor Activity of Artemisinin - From Bench to Bedside

    Thomas Efferth

Frequent Co-Authors

Yu-Jie Fu
Yu-Jie Fu Northeast Forestry University
Yuangang Zu
Yuangang Zu Northeast Forestry University
Yoshikazu Sugimoto
Yoshikazu Sugimoto Keio University
Jose J.G. Marin
Jose J.G. Marin University of Salamanca
Michael Wink
Michael Wink Heidelberg University
Bernd Kaina
Bernd Kaina Johannes Gutenberg University of Mainz
Chunjian Zhao
Chunjian Zhao Northeast Forestry University
Marcel Kaiser
Marcel Kaiser Swiss Tropical and Public Health Institute
José Remacle
José Remacle University of Namur
Jörg D. Hoheisel
Jörg D. Hoheisel German Cancer Research Center

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