World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
52
Citations
20917
World Ranking
3757
National Ranking
1621

Research.com Recognitions

  • 2011 - Member of the National Academy of Sciences
  • 2010 - Fellow of the American Academy of Arts and Sciences

Overview

Daniel E. Gottschling is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a notable emphasis on Molecular Biology, Aging, and Cell Biology. The scientist's work spans several interconnected subfields including Biochemistry and Physiology.

Their recent publications cover a range of topics within cellular and molecular biology, aging, and metabolic regulation. Some key papers include:

  • rDNA array length is a major determinant of replicative lifespan in budding yeast, 2022, Proceedings of the National Academy of Sciences
  • Independent regulation of age associated fat accumulation and longevity, 2020, Nature Communications
  • Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth, 2023, Nature Metabolism
  • Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • The Yeast Lifespan Machine: a microfluidic platform for automated replicative lifespan measurements, 2022, bioRxiv (Cold Spring Harbor Laboratory)

Gottschling's research topics broadly encompass:

  • Genetics, Aging, and Longevity in Model Organisms
  • Mitochondrial Function and Pathology
  • Microbial Metabolic Engineering and Bioproduction
  • Cellular transport and secretion
  • Endoplasmic Reticulum Stress and Disease
  • DNA Repair Mechanisms
  • Fungal and yeast genetics research

The scientist frequently collaborates with others in their field. Notable frequent coauthors include:

  • Nathaniel H. Thayer
  • Voytek Okreglak
  • Alfred Millett-Sikking
  • Manuel Hotz
  • Elizabeth L. Schinski

Gottschling's work has been published in venues like bioRxiv (Cold Spring Harbor Laboratory), Nature Metabolism, Proceedings of the National Academy of Sciences, Nature Communications, and the Annual Review of Cell and Developmental Biology.

The scientist has been recognized by election to prestigious academies, including becoming a Fellow of the American Academy of Arts and Sciences in 2010 and a Member of the National Academy of Sciences in 2011.

Best Publications

  • Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

    Kelly Kruger;Paula J. Grabowski;Arthur J. Zaug;Julie Sands

  • Position Effect at S. cerevisiae Telomeres: Reversible Repression of Pol II Transcription

    Daniel E. Gottschling;Oscar M. Aparicio;Barbara L. Billington;Virginia A. Zakian

  • Dot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core

    Fred van Leeuwen;Philip R. Gafken;Daniel E. Gottschling

  • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase

    Miriam S. Singer;Daniel E. Gottschling

  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

    Dirk Schübeler;David M. MacAlpine;David Scalzo;Christiane Wirbelauer

  • Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

    Oscar M. Aparicio;Barbara L. Billington;Daniel E. Gottschling

  • An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

    Adam L. Hughes;Daniel E. Gottschling

  • Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.

    Hubert Renauld;Oscar M. Aparicio;Paul D. Zierath;Barbara L. Billington

  • Identification of High-Copy Disruptors of Telomeric Silencing in Saccharomyces cerevisiae

    Miriam S. Singer;Alon Kahana;Alon Kahana;Alexander J. Wolf;Lia L. Meisinger

  • The Major Cytoplasmic Histone Acetyltransferase in Yeast: Links to Chromatin Replication and Histone Metabolism

    Mark R Parthun;Jonathan Widom;Daniel E Gottschling

  • Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

    Jessica S. Dymond;Sarah M. Richardson;Candice E. Coombes;Timothy Babatz

  • Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ

    Scott J Diede;Scott J Diede;Daniel E Gottschling

  • Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

    Joshua R. Veatch;Michael A. McMurray;Michael A. McMurray;Michael A. McMurray;Zara W. Nelson;Daniel E. Gottschling

  • Identification of a small molecule inhibitor of Sir2p

    Antonio Bedalov;Tonibelle Gatbonton;William P. Irvine;Daniel E. Gottschling

  • Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA.

    Daniel E. Gottschling;Virginia Araxie Zakian

  • Saccharomyces telomeres assume a non-nucleosomal chromatin structure.

    Jocelyn H. Wright;Daniel E. Gottschling;Virginia A. Zakian

  • Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

    Anne E. Stellwagen;Zara W. Haimberger;Joshua R. Veatch;Daniel E. Gottschling

  • Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.

    Oscar M. Aparicio;Daniel E. Gottschling

  • Degradation-mediated protein quality control in the nucleus.

    Richard G. Gardner;Zara W. Nelson;Daniel E. Gottschling

  • Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.

    Daniel E. Gottschling

Frequent Co-Authors

Virginia A. Zakian
Virginia A. Zakian Princeton University
Thomas R. Cech
Thomas R. Cech University of Colorado Boulder
Thomas Nyström
Thomas Nyström University of Gothenburg
Mark Groudine
Mark Groudine Fred Hutchinson Cancer Research Center
James R. Broach
James R. Broach Pennsylvania State University
Dirk Schübeler
Dirk Schübeler Friedrich Miescher Institute
Jef D. Boeke
Jef D. Boeke New York University
Jeffrey J. Delrow
Jeffrey J. Delrow Fred Hutchinson Cancer Research Center
Susan W. Liebman
Susan W. Liebman University of Nevada Reno
Charles Kooperberg
Charles Kooperberg Fred Hutchinson Cancer Research Center

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