World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
87
Citations
33670
World Ranking
1199
National Ranking
18

Research.com Recognitions

  • 2012 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Dirk Schübeler is affiliated with the Friedrich Miescher Institute in Switzerland and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, genetics, and cell biology, with additional work related to plant science and oncology.

The scientist has published 74 papers in these main fields, with notable subfields including molecular biology (64 publications), genetics (6 publications), cell biology (4 publications), plant science (2 publications), and oncology (1 publication).

Key research topics addressed in their work include:

  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • CRISPR and Genetic Engineering
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Cancer-related gene regulation
  • Genetics and Neurodevelopmental Disorders

Among their recent papers are the following:

  • Mechanisms of OCT4-SOX2 motif readout on nucleosomes, 2020, Science
  • A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity, 2020, Nature Communications
  • Mammalian SWI/SNF continuously restores local accessibility to chromatin, 2021, Nature Genetics
  • Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation, 2022, Nature Genetics
  • Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo, 2020, Molecular Cell

Dirk Schübeler has frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory) with 9 publications, followed by Nature Genetics with 6 papers, Molecular Cell with 4, Nature Communications with 3, and Nature with 2.

The scientist has collaborated extensively with several researchers, including Lukas Burger (15 co-authored works), Luke Isbel (11 co-authored works), Ralph S. Grand (8 co-authored works), Sevi Durdu (8 co-authored works), and Murat Iskar (8 co-authored works).

Dirk Schübeler has been recognized by membership in scientific organizations, including being a Member of Academia Europaea since 2012 and a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome.

    Michael Weber;Ines Hellmann;Michael B Stadler;Liliana Ramos

  • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells.

    Michael Weber;Jonathan J Davies;David Wittig;Edward J Oakeley

  • Function and information content of DNA methylation

    Dirk Schübeler

  • DNA-binding factors shape the mouse methylome at distal regulatory regions

    Michael B. Stadler;Rabih Murr;Lukas Burger;Lukas Burger;Robert Ivanek

  • Impact of cytosine methylation on DNA binding specificities of human transcription factors.

    Yimeng Yin;Ekaterina Morgunova;Arttu Jolma;Eevi Kaasinen

  • Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors

    Fabio Mohn;Michael Weber;Michael Rebhan;Tim C. Roloff

  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

    Dirk Schübeler;David M. MacAlpine;David Scalzo;Christiane Wirbelauer

  • Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

    Urszula Brykczynska;Mizue Hisano;Serap Erkek;Liliana Ramos

  • Targets and dynamics of promoter DNA methylation during early mouse development

    Julie Borgel;Sylvain Guibert;Yufeng Li;Yufeng Li;Hatsune Chiba

  • Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

    Tuncay Baubec;Daniele F. Colombo;Christiane Wirbelauer;Juliane Schmidt

  • Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

    Ichiro Hiratani;Tyrone Ryba;Mari Itoh;Tomoki Yokochi

  • Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs

    Jacek Krol;Volker Busskamp;Ilona Markiewicz;Michael B. Stadler

  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Hendrik G. Stunnenberg;Martin Hirst

  • Determinants and dynamics of genome accessibility

    Oliver Bell;Vijay K. Tiwari;Nicolas H. Thomä;Dirk Schübeler;Dirk Schübeler

  • Sox4 is a master regulator of epithelial-mesenchymal transition by controlling ezh2 expression and epigenetic reprogramming

    Neha Tiwari;Vijay K. Tiwari;Lorenz Waldmeier;Piotr J. Balwierz

  • Competition between DNA methylation and transcription factors determines binding of NRF1

    Silvia Domcke;Silvia Domcke;Anaïs Flore Bardet;Paul Adrian Ginno;Dominik Hartl;Dominik Hartl

  • Genomic patterns of DNA methylation: targets and function of an epigenetic mark.

    Michael Weber;Dirk Schübeler

  • Identification of genetic elements that autonomously determine DNA methylation states

    Florian Lienert;Christiane Wirbelauer;Indrani Som;Ann Dean

  • Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing.

    Dirk Schübeler;David Scalzo;Charles Kooperberg;Bas van Steensel

  • Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus

    Dirk Schübeler;Claire Francastel;Daniel M. Cimbora;Andreas Reik

Frequent Co-Authors

Mark Groudine
Mark Groudine Fred Hutchinson Cancer Research Center
Michael B. Stadler
Michael B. Stadler Friedrich Miescher Institute
Antoine H.F.M. Peters
Antoine H.F.M. Peters Friedrich Miescher Institute
Botond Roska
Botond Roska University of Basel
Erik van Nimwegen
Erik van Nimwegen University of Basel
Hitoshi Kurumizaka
Hitoshi Kurumizaka University of Tokyo
David I. K. Martin
David I. K. Martin UCSF Benioff Children's Hospital
Charles Kooperberg
Charles Kooperberg Fred Hutchinson Cancer Research Center
Tewis Bouwmeester
Tewis Bouwmeester Novartis (Switzerland)

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