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Molecular Biology

D-Index
52
Citations
27916
World Ranking
2404
National Ranking
42

Overview

Tewis Bouwmeester is affiliated with Novartis in Switzerland. Their research activity spans several key areas within the broader fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Bouwmeester's work includes a significant focus on Molecular Biology, along with contributions to Cognitive Neuroscience, Genetics, Cell Biology, and Hepatology.

The scientist's research topics cover:

  • Epigenetics and DNA Methylation
  • Wnt/β-catenin signaling in development and cancer
  • Neural dynamics and brain function
  • Memory and Neural Mechanisms
  • Liver physiology and pathology
  • Hemoglobinopathies and Related Disorders
  • Liver Disease Diagnosis and Treatment

Bouwmeester has published articles in journals such as Cell Stem Cell, Nature Methods, Nature, Science, and Neuron. Among their recent papers are:

  • "A virtual reality system to analyze neural activity and behavior in adult zebrafish" (2020) published in Nature Methods
  • "ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation" (2021) published in Cell Stem Cell
  • "State-dependent encoding of exploratory behaviour in the amygdala" (2021) published in Nature
  • "A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction" (2024) published in Science
  • "Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling" (2022) published in Neuron

Frequent collaborators in Bouwmeester's research include Heinz Ruffner, Guglielmo Roma, Alexandra Aebi, Stefano Annunziato, and Vanessa Orsini. These coauthors contribute to a range of publications highlighting multidisciplinary efforts.

The scientist's frequent publication venues reflect an engagement with high-impact journals across both molecular biology and neuroscience disciplines, including:

  • Cell Stem Cell
  • Nature Methods
  • Nature
  • Science
  • Neuron

Throughout their career, Bouwmeester has contributed primarily to the understanding of molecular mechanisms underlying liver physiology and pathology, neural functions related to memory and behavior, as well as genetic regulation related to epigenetics and hematology.

Best Publications

  • Functional organization of the yeast proteome by systematic analysis of protein complexes

    Anne-Claude Gavin;Markus Bösche;Roland Krause;Paola Grandi

  • Proteome survey reveals modularity of the yeast cell machinery

    Anne-Claude Gavin;Patrick Aloy;Paola Grandi;Roland Krause

  • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

    Shih Min A Huang;Yuji M. Mishina;Shanming Liu;Atwood Cheung

  • A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

    Tewis Bouwmeester;Angela Bauch;Heinz Ruffner;Pierre-Olivier Angrand

  • The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.

    Stefano Piccolo;Stefano Piccolo;Eric Agius;Luc Leyns;Luc Leyns;Subha Bhattacharyya

  • Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

    Marcus Bantscheff;Dirk Eberhard;Yann Abraham;Sonja Bastuck

  • ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

    Huai-Xiang Hao;Yang Xie;Yue Zhang;Yue Zhang;Olga Charlat

  • Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann Organizer.

    Luc Leyns;Tewis Bouwmeester;Sung-Hyun Kim;Stefano Piccolo

  • Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

    Tewis Bouwmeester;Sung-Hyun Kim;Yoshiki Sasai;Bin Lu

  • Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

    Frank W. Schmitges;Archana B. Prusty;Mahamadou Faty;Alexandra Stützer

  • Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

    José António Belo;Tewis Bouwmeester;Luc Leyns;Nathalie Kertesz

  • YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

    Claudia Stein;Anaïs Flore Bardet;Guglielmo Roma;Sebastian Bergling

  • The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation.

    S.H. Kim;A. Yamamoto;T. Bouwmeester;E. Agius

  • Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function

    Olivier Leupin;Elke Piters;Christine Halleux;Shouih Hu

  • The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

    Lara Planas-Paz;Vanessa Orsini;Luke Boulter;Diego Calabrese

  • Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

    Zainab Jagani;E. Lorena Mora-Blanco;Courtney G. Sansam;Elizabeth S. McKenna

  • Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo.

    Alexander Dick;Marc Hild;Hermann Bauer;Yoshiyuki Imai

  • Comprehensive Proteomic Analysis of Human Par Protein Complexes Reveals an Interconnected Protein Network

    Miro Brajenovic;Gerard Joberty;Bernhard Küster;Tewis Bouwmeester

  • The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo.

    Marc Hild;Alexander Dick;Gerd-Jörg Rauch;Andrea Meier

  • Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

    Jason Borawski;Philip Troke;Xiaoling Puyang;Veronica Gibaja

Frequent Co-Authors

Guglielmo Roma
Guglielmo Roma Novartis (Switzerland)
Gerard Drewes
Gerard Drewes GlaxoSmithKline (United Kingdom)
Bernhard Kuster
Bernhard Kuster Technical University of Munich
Markus Schirle
Markus Schirle Novartis (Switzerland)
Giulio Superti-Furga
Giulio Superti-Furga Medical University of Vienna
Tomas Pieler
Tomas Pieler University of Göttingen
Corinne Antignac
Corinne Antignac Institut Imagine
Markus H. Heim
Markus H. Heim University Hospital of Basel
Andreas Lüthi
Andreas Lüthi Friedrich Miescher Institute
Luigi Terracciano
Luigi Terracciano University Hospital of Basel

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