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D-Index & Metrics

Molecular Biology

D-Index
49
Citations
22291
World Ranking
2590
National Ranking
47

Overview

Markus Schirle is a researcher affiliated with Novartis in Switzerland. Their work spans significant areas within biochemistry, genetics, and molecular biology, with particular focus on molecular biology, organic chemistry, oncology, hematology, and computational theory and mathematics.

Their research principally addresses topics such as protein degradation and inhibitors, ubiquitin and proteasome pathways, peptidase inhibition and analysis, click chemistry and applications, multiple myeloma research and treatments, chemical synthesis and analysis, and RNA and protein synthesis mechanisms.

Markus Schirle has contributed extensively to the body of scientific literature. Notable recent papers include:

  • Deubiquitinase-targeting chimeras for targeted protein stabilization (2022), published in Nature Chemical Biology
  • Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications (2022), published in Journal of the American Chemical Society
  • Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function (2021), published in Cell chemical biology
  • Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC (2020), published in Cell chemical biology
  • Rational Chemical Design of Molecular Glue Degraders (2023), published in ACS Central Science

They frequently collaborate with other researchers including Daniel K. Nomura, Jeffrey M. McKenna, John A. Tallarico, Scott M. Brittain, and Dustin Dovala.

Their work is often published in prominent venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Chemical Biology, ACS Chemical Biology, Journal of the American Chemical Society, and Cell chemical biology.

Best Publications

  • Proteome survey reveals modularity of the yeast cell machinery

    Anne-Claude Gavin;Patrick Aloy;Paola Grandi;Roland Krause

  • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

    Shih Min A Huang;Yuji M. Mishina;Shanming Liu;Atwood Cheung

  • Quantitative mass spectrometry in proteomics: a critical review

    Marcus Bantscheff;Markus Schirle;Gavain Sweetman;Jens Rick

  • A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

    Tewis Bouwmeester;Angela Bauch;Heinz Ruffner;Pierre-Olivier Angrand

  • Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

    Eric S. Fischer;Kerstin Böhm;John R. Lydeard;Haidi Yang

  • Dermcidin: a novel human antibiotic peptide secreted by sweat glands.

    Birgit Schittek;Rainer Hipfel;Birgit Sauer;Jürgen Bauer

  • Computational prediction of proteotypic peptides for quantitative proteomics

    Parag Mallick;Markus Schirle;Sharon S Chen;Mark R Flory

  • Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

    William E. Dowdle;Beat Nyfeler;Jane Nagel;Robert A. Elling

  • Discrete Cleavage Motifs of Constitutive and Immunoproteasomes Revealed by Quantitative Analysis of Cleavage Products

    R. E.M. Toes;A. K. Nussbaum;S. Degermann;M. Schirle

  • The HLA-A*6601 peptide motif: prediction by pocket structure and verification by peptide analysis

    Florian H. Seeger;Markus Schirle;John Gatfield;Danièle Arnold

  • Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

    Alexander K. Nussbaum;Tobias P. Dick;Wieland Keilholz;Markus Schirle

  • RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

    Yue Zhang;Shanming Liu;Craig Mickanin;Yan Feng

  • Scoring proteomes with proteotypic peptide probes

    Bernhard Kuster;Markus Schirle;Parag Mallick;Ruedi Aebersold

  • Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

    Tobias P. Dick;Alexander K. Nussbaum;Martin Deeg;Wolfgang Heinemeyer

  • Two new proteases in the MHC class I processing pathway

    Lars Stoltze;Markus Schirle;Gerold Schwarz;Christian Schröter

  • Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

    Jessica N. Spradlin;Jessica N. Spradlin;Xirui Hu;Xirui Hu;Carl C. Ward;Carl C. Ward;Scott M. Brittain

  • Integrated functional genomics approach for the design of patient-individual antitumor vaccines.

    Toni Weinschenk;Cécile Gouttefangeas;Markus Schirle;Florian Obermayr

  • Bartonella Adhesin A Mediates a Proangiogenic Host Cell Response

    Tanja Riess;Siv G.E. Andersson;Andrei Lupas;Martin Schaller

  • Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function

    Olivier Leupin;Elke Piters;Christine Halleux;Shouih Hu

  • Profiling Core Proteomes of Human Cell Lines by One-dimensional PAGE and Liquid Chromatography-Tandem Mass Spectrometry

    Markus Schirle;Marie-Anne Heurtier;Bernhard Kuster

Frequent Co-Authors

Stefan Stevanovic
Stefan Stevanovic University of Tübingen
Daniel K. Nomura
Daniel K. Nomura University of California, Berkeley
Bernhard Kuster
Bernhard Kuster Technical University of Munich
Tewis Bouwmeester
Tewis Bouwmeester Novartis (Switzerland)
Hansjörg Schild
Hansjörg Schild Johannes Gutenberg University of Mainz
Hans-Georg Rammensee
Hans-Georg Rammensee University of Tübingen
Guglielmo Roma
Guglielmo Roma Novartis (Switzerland)
Marcus Bantscheff
Marcus Bantscheff GlaxoSmithKline (United Kingdom)
Christine D. Wilson
Christine D. Wilson McMaster University
Wolfgang Wohlleben
Wolfgang Wohlleben University of Tübingen

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