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Genetics

D-Index
61
Citations
19318
World Ranking
3034
National Ranking
50

Overview

Patrick Aloy is affiliated with the Institució Catalana de Recerca i Estudis Avançats in Spain. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, with a strong focus also on Computer Science. The primary subfields of their work include Molecular Biology, Computational Theory and Mathematics, Pharmacology, Biophysics, and Infectious Diseases.

Their scientific contributions cover a range of topics such as Computational Drug Discovery Methods, Bioinformatics and Genomic Networks, Microbial Natural Products and Biosynthesis, Microbial Metabolic Engineering and Bioproduction, Fungal and Yeast Genetics Research, Cell Image Analysis Techniques, and Machine Learning in Materials Science.

Patrick Aloy has frequently published in several notable venues, with a significant number of articles appearing in bioRxiv (Cold Spring Harbor Laboratory). Other frequent publication venues include Nature Biotechnology, Nature Communications, Molecular Systems Biology, and Genome Medicine.

Among recent publications, the following papers highlight key areas of Aloy's research activity:

  • Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker, 2020, Nature Biotechnology
  • Bioactivity descriptors for uncharacterized chemical compounds, 2021, Nature Communications
  • Environmental robustness of the global yeast genetic interaction network, 2021, Science
  • Systematic analysis of bypass suppression of essential genes, 2020, Molecular Systems Biology
  • Connecting chemistry and biology through molecular descriptors, 2021, Current Opinion in Chemical Biology

Collaboration is an important aspect of Aloy's research. Frequent co-authors include Miquel Duran-Frigola, Carles Pons, Martino Bertoni, Adrià Fernández-Torras, and Oriol Guitart-Pla.

Best Publications

  • Proteome survey reveals modularity of the yeast cell machinery

    Anne-Claude Gavin;Patrick Aloy;Paola Grandi;Roland Krause

  • A proteome-scale map of the human interactome network

    Thomas Rolland;Murat Taşan;Benoit Charloteaux;Samuel J. Pevzner

  • A reference map of the human binary protein interactome

    Katja Luck;Dae Kyum Kim;Luke Lambourne;Kerstin Spirohn

  • Systems analysis of intracellular pH vulnerabilities for cancer therapy.

    Erez Persi;Erez Persi;Miquel Duran-Frigola;Mehdi Damaghi;William R. Roush

  • Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

    Xinping Yang;Xinping Yang;Jasmin Coulombe-Huntington;Shuli Kang;Gloria M. Sheynkman

  • Relation between amino acid composition and cellular location of proteins.

    Juan Cedano;Patrick Aloy;Josep A. Pérez-Pons;Enrique Querol

  • Interactome3D: adding structural details to protein networks

    Roberto Mosca;Arnaud Céol;Patrick Aloy

  • Structure-Based Assembly of Protein Complexes in Yeast

    Patrick Aloy;Bettina Böttcher;Hugo Ceulemans;Christina Leutwein

  • Interrogating protein interaction networks through structural biology

    Patrick Aloy;Robert B. Russell

  • Structural systems biology: modelling protein interactions

    Patrick Aloy;Patrick Aloy;Robert B. Russell

  • The relationship between sequence and interaction divergence in proteins.

    Patrick Aloy;Hugo Ceulemans;Alexander Stark;Robert B. Russell

  • Unveiling the role of network and systems biology in drug discovery.

    Albert Pujol;Roberto Mosca;Judith Farrés;Patrick Aloy;Patrick Aloy

  • Automated structure-based prediction of functional sites in proteins: applications to assessing the validity of inheriting protein function from homology in genome annotation and to protein docking.

    Patrick Aloy;Enrique Querol;Francesc X. Aviles;Michael J.E. Sternberg

  • A structural perspective on protein-protein interactions.

    Robert B Russell;Robert B Russell;Frank Alber;Patrick Aloy;Fred P Davis

  • InterPreTS: protein interaction prediction through tertiary structure.

    Patrick Aloy;Robert B. Russell

  • 3did: a catalog of domain-based interactions of known three-dimensional structure

    Roberto Mosca;Arnaud Céol;Amelie Stein;Roger Olivella

  • The binary protein-protein interaction landscape of Escherichia coli

    Seesandra V Rajagopala;Patricia Sikorski;Ashwani Kumar;Roberto Mosca

  • 3did: interacting protein domains of known three-dimensional structure

    Amelie Stein;Robert B. Russell;Patrick Aloy

  • Ten thousand interactions for the molecular biologist

    Patrick Aloy;Robert B Russell

  • Exploring genetic suppression interactions on a global scale

    Jolanda van Leeuwen;Carles Pons;Joseph C. Mellor;Joseph C. Mellor;Takafumi N. Yamaguchi;Takafumi N. Yamaguchi

Frequent Co-Authors

Robert B. Russell
Robert B. Russell Heidelberg University
Frederick P. Roth
Frederick P. Roth Lunenfeld-Tanenbaum Research Institute
Marc Vidal
Marc Vidal Harvard University
David E. Hill
David E. Hill Harvard University
Yves Jacob
Yves Jacob Institut Pasteur
Francesc X. Avilés
Francesc X. Avilés Autonomous University of Barcelona
Peer Bork
Peer Bork European Molecular Biology Laboratory
Jan Tavernier
Jan Tavernier Ghent University
Albert-László Barabási
Albert-László Barabási Northeastern University
Anne-Claude Gavin
Anne-Claude Gavin University of Geneva

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