World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
42
Citations
11977
World Ranking
2999
National Ranking
1424

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Lorraine Pillus is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a total of 20 publications in these areas. Within these domains, the scientist has contributed extensively to Molecular Biology, Aging, and Materials Chemistry, with Molecular Biology comprising the majority of their work.

Their scholarly output includes studies covering key topics such as Genomics and Chromatin Dynamics, Fungal and Yeast Genetics Research, Genetics, Aging, and Longevity in Model Organisms, DNA Repair Mechanisms, RNA Research and Splicing, RNA Modifications and Cancer, and Ubiquitin and Proteasome Pathways.

Recent papers authored or co-authored by Lorraine Pillus include the following:

  • A programmable fate decision landscape underlies single-cell aging in yeast (2020, Science)
  • Engineering longevity-design of a synthetic gene oscillator to slow cellular aging (2023, Science)
  • Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis (2022, eLife)
  • Cell cycle roles for GCN5 revealed through genetic suppression (2020, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms)
  • Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with loss of proteostasis (2021, bioRxiv (Cold Spring Harbor Laboratory))

Lorraine Pillus frequently collaborates with several researchers, including:

  • Lev S. Tsimring
  • Jeff Hasty
  • Nan Hao
  • Yang Li
  • Yanfei Jiang

The scientist's work has been published in reputable venues, including:

  • Science
  • eLife
  • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  • bioRxiv (Cold Spring Harbor Laboratory)
  • G3 Genes Genomes Genetics

Lorraine Pillus was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2017, an award listed twice in the available data.

Best Publications

  • The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.

    Joseph Landry;Ann Sutton;Stefan T. Tafrov;Ryan C. Heller

  • New nomenclature for chromatin-modifying enzymes.

    C. David Allis;Shelley L. Berger;Jacques Cote;Sharon R Dent

  • Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8

    Karl W. Henry;Anastasia Wyce;Wan Sheng Lo;Laura J. Duggan

  • The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

    Carrie Baker Brachmann;Joyce M. Sherman;Scott E. Devine;Elizabeth E. Cameron

  • NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p.

    Stéphane Allard;Rhea T. Utley;Julie Savard;Astrid Clarke

  • SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

    F. Palladino;T. Laroche;E. Gilson;A. Axelrod

  • Epigenetic inheritance of transcriptional states in S. cerevisiae

    Lorraine Pillus;Jasper Rine

  • Yeast SAS silencing genes and human genes associated with AML and HIV–1 Tat interactions are homologous with acetyltransferases

    Cheryl Reifsnyder;Joanna Lowell;Astrid Clarke;Lorraine Pillus

  • Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres

    Götz Laible;Andrea Wolf;Rainer Dorn;Gunter Reuter

  • SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.

    Corey Nislow;Evan Ray;Lorraine Pillus

  • Histone H3 specific acetyltransferases are essential for cell cycle progression

    LeAnn Howe;Darryl Auston;Patrick Grant;Sam John

  • Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins.

    P J Schatz;L Pillus;P Grisafi;F Solomon

  • Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.

    Jeffrey S. Smith;Carrie Baker Brachmann;Lorraine Pillus;Jef D. Boeke

  • Structural Basis for Histone and Phosphohistone Binding by the GCN5 Histone Acetyltransferase

    Adrienne Clements;Arienne N Poux;Arienne N Poux;Wan-Sheng Lo;Lorraine Pillus

  • Modifying chromatin and concepts of cancer.

    Sandra Jacobson;Lorraine Pillus

  • Genome wide analysis of nucleosome density histone acetylation and HDAC function in fission yeast

    Marianna Wirén;Rebecca A Silverstein;Indranil Sinha;Julian Walfridsson

  • The Conserved Core of a Human SIR2 Homologue Functions in Yeast Silencing

    Joyce M. Sherman;Elisa M. Stone;Lisa L. Freeman-Cook;Carrie B. Brachmann

  • Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms

    Wan-Sheng Lo;Eric R Gamache;Karl W Henry;David Yang

  • Balancing chromatin remodeling and histone modifications in transcription.

    Emily Petty;Lorraine Pillus

  • Activation of an MAP kinase cascade leads to Sir3p hyperphosphorylation and strengthens transcriptional silencing.

    E M Stone;L Pillus

Frequent Co-Authors

Lev S. Tsimring
Lev S. Tsimring University of California, San Diego
Jeff Hasty
Jeff Hasty University of California, San Diego
Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Jerry L. Workman
Jerry L. Workman Stowers Institute for Medical Research
Jef D. Boeke
Jef D. Boeke New York University
Brian K. Kennedy
Brian K. Kennedy National University of Singapore
Ronen Marmorstein
Ronen Marmorstein University of Pennsylvania
Susan M. Gasser
Susan M. Gasser Friedrich Miescher Institute
Jacques Côté
Jacques Côté Université Laval
Patrick A. Grant
Patrick A. Grant University of Virginia

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