World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
92
Citations
35396
World Ranking
2195
National Ranking
1185

John M. Denu publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where John M. Denu sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 281 publications — 75th percentile

75% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

John M. Denu D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where John M. Denu sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 92 D-Index — 89th percentile

89% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John M. Denu is affiliated with the University of Wisconsin-Madison in the United States. Their research primarily spans the disciplines of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine.

Their work focuses on several specialized subfields, including Molecular Biology, Physiology, Geriatrics and Gerontology, Aging, and Cell Biology. The scientist explores diverse topics such as Sirtuins and Resveratrol in Medicine, Epigenetics and DNA Methylation, Gut microbiota and health, RNA modifications and cancer, Genetics, Aging, and Longevity in Model Organisms, Adipose Tissue and Metabolism, and Calcium signaling and nucleotide metabolism.

John M. Denu has published extensively in notable venues. The most frequent publication outlets include the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Molecular Cell, and Communications Biology.

Recent significant papers include:

  • Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice, 2021, Nature Metabolism
  • Gut microbiome variation modulates the effects of dietary fiber on host metabolism, 2021, Microbiome
  • Metabolism and the Epigenome: A Dynamic Relationship, 2020, Trends in Biochemical Sciences
  • Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence, 2020, Molecular Cell
  • Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators, 2020, Journal of Biological Chemistry

The scientist has collaborated frequently with several coauthors, including:

  • Mark T. Bedford
  • Lila M. Gierasch
  • F. Peter Guengerich
  • Ruma Banerjee
  • Roger Colbran

John M. Denu received the distinction of Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

    Brian J North;Brett L Marshall;Margie T Borra;John M Denu

  • Mechanism of Human SIRT1 Activation by Resveratrol

    Margie T. Borra;Brian C. Smith;John M. Denu

  • Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

    Shinichi Someya;Shinichi Someya;Wei Yu;William C. Hallows;Jinze Xu

  • Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation.

    John M. Denu;Kirk G. Tanner

  • Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation.

    Peter Cheung;Kirk G Tanner;Wang L Cheung;Paolo Sassone-Corsi

  • Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.

    William C. Hallows;Susan Lee;John M. Denu

  • Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

    Kirk G. Tanner;Joseph Landry;Rolf Sternglanz;John M. Denu

  • Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

    Clara Bien Peek;Alison H. Affinati;Kathryn Moynihan Ramsey;Hsin-Yu Kuo;Hsin-Yu Kuo

  • Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

    Alexander S. Hebert;Kristin E. Dittenhafer-Reed;Wei Yu;Derek J. Bailey

  • Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

    Jessica L. Feldman;Josue Baeza;John M. Denu

  • Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

    Kimberly A. Krautkramer;Julia H. Kreznar;Kymberleigh A. Romano;Eugenio I. Vivas

  • Protein tyrosine phosphatases: mechanisms of catalysis and regulation.

    John M Denu;Jack E Dixon

  • SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

    Tadahiro Shimazu;Matthew D. Hirschey;Lan Hua;Kristin E. Dittenhafer-Reed

  • Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model

    Kazuyuki Kasahara;Kimberly A. Krautkramer;Elin Org;Kymberleigh A. Romano

  • Form and Function in Protein Dephosphorylation

    John M Denu;Jeanne A Stuckey;Mark A Saper;Jack E Dixon

  • Crystal Structure of the Dual Specificity Protein Phosphatase VHR

    Jirundon Yuvaniyama;John M. Denu;Jack E. Dixon;Mark A. Saper

  • SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

    Wei Yu;Kristin E. Dittenhafer-Reed;John M. Denu

  • A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase.

    Matthew J. Wishart;John M. Denu;John A. Williams;Jack E. Dixon

  • Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

    William C. Hallows;Wei Yu;Brian C. Smith;Mark K. Devries

  • Chemical mechanisms of histone lysine and arginine modifications.

    Brian C. Smith;John M. Denu

Frequent Co-Authors

Jack E. Dixon
Jack E. Dixon University of California, San Diego
Joshua J. Coon
Joshua J. Coon University of Wisconsin–Madison
Tatiana G. Kutateladze
Tatiana G. Kutateladze University of Colorado Denver
Paul F. Fitzpatrick
Paul F. Fitzpatrick The University of Texas Health Science Center at San Antonio
Tomas A. Prolla
Tomas A. Prolla University of Wisconsin–Madison
Dudley W. Lamming
Dudley W. Lamming University of Wisconsin–Madison
Joel P. Mackay
Joel P. Mackay University of Sydney
Raul Mostoslavsky
Raul Mostoslavsky Harvard University
Federico E. Rey
Federico E. Rey University of Wisconsin–Madison
Benjamin A. Garcia
Benjamin A. Garcia Washington University in St. Louis

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