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D-Index & Metrics

Biology and Biochemistry

D-Index
92
Citations
35396
World Ranking
2195
National Ranking
1185

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John M. Denu is affiliated with the University of Wisconsin-Madison in the United States. Their research primarily spans the disciplines of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine.

Their work focuses on several specialized subfields, including Molecular Biology, Physiology, Geriatrics and Gerontology, Aging, and Cell Biology. The scientist explores diverse topics such as Sirtuins and Resveratrol in Medicine, Epigenetics and DNA Methylation, Gut microbiota and health, RNA modifications and cancer, Genetics, Aging, and Longevity in Model Organisms, Adipose Tissue and Metabolism, and Calcium signaling and nucleotide metabolism.

John M. Denu has published extensively in notable venues. The most frequent publication outlets include the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Molecular Cell, and Communications Biology.

Recent significant papers include:

  • Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice, 2021, Nature Metabolism
  • Gut microbiome variation modulates the effects of dietary fiber on host metabolism, 2021, Microbiome
  • Metabolism and the Epigenome: A Dynamic Relationship, 2020, Trends in Biochemical Sciences
  • Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence, 2020, Molecular Cell
  • Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators, 2020, Journal of Biological Chemistry

The scientist has collaborated frequently with several coauthors, including:

  • Mark T. Bedford
  • Lila M. Gierasch
  • F. Peter Guengerich
  • Ruma Banerjee
  • Roger Colbran

John M. Denu received the distinction of Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

    Brian J North;Brett L Marshall;Margie T Borra;John M Denu

  • Mechanism of Human SIRT1 Activation by Resveratrol

    Margie T. Borra;Brian C. Smith;John M. Denu

  • Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

    Shinichi Someya;Shinichi Someya;Wei Yu;William C. Hallows;Jinze Xu

  • Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation.

    John M. Denu;Kirk G. Tanner

  • Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation.

    Peter Cheung;Kirk G Tanner;Wang L Cheung;Paolo Sassone-Corsi

  • Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.

    William C. Hallows;Susan Lee;John M. Denu

  • Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

    Kirk G. Tanner;Joseph Landry;Rolf Sternglanz;John M. Denu

  • Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

    Clara Bien Peek;Alison H. Affinati;Kathryn Moynihan Ramsey;Hsin-Yu Kuo;Hsin-Yu Kuo

  • Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

    Alexander S. Hebert;Kristin E. Dittenhafer-Reed;Wei Yu;Derek J. Bailey

  • Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

    Jessica L. Feldman;Josue Baeza;John M. Denu

  • Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

    Kimberly A. Krautkramer;Julia H. Kreznar;Kymberleigh A. Romano;Eugenio I. Vivas

  • Protein tyrosine phosphatases: mechanisms of catalysis and regulation.

    John M Denu;Jack E Dixon

  • SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

    Tadahiro Shimazu;Matthew D. Hirschey;Lan Hua;Kristin E. Dittenhafer-Reed

  • Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model

    Kazuyuki Kasahara;Kimberly A. Krautkramer;Elin Org;Kymberleigh A. Romano

  • Form and Function in Protein Dephosphorylation

    John M Denu;Jeanne A Stuckey;Mark A Saper;Jack E Dixon

  • Crystal Structure of the Dual Specificity Protein Phosphatase VHR

    Jirundon Yuvaniyama;John M. Denu;Jack E. Dixon;Mark A. Saper

  • SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

    Wei Yu;Kristin E. Dittenhafer-Reed;John M. Denu

  • A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase.

    Matthew J. Wishart;John M. Denu;John A. Williams;Jack E. Dixon

  • Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

    William C. Hallows;Wei Yu;Brian C. Smith;Mark K. Devries

  • Chemical mechanisms of histone lysine and arginine modifications.

    Brian C. Smith;John M. Denu

Frequent Co-Authors

Jack E. Dixon
Jack E. Dixon University of California, San Diego
Joshua J. Coon
Joshua J. Coon University of Wisconsin–Madison
Tatiana G. Kutateladze
Tatiana G. Kutateladze University of Colorado Denver
Paul F. Fitzpatrick
Paul F. Fitzpatrick The University of Texas Health Science Center at San Antonio
Tomas A. Prolla
Tomas A. Prolla University of Wisconsin–Madison
Dudley W. Lamming
Dudley W. Lamming University of Wisconsin–Madison
Joel P. Mackay
Joel P. Mackay University of Sydney
Raul Mostoslavsky
Raul Mostoslavsky Harvard University
Federico E. Rey
Federico E. Rey University of Wisconsin–Madison
Benjamin A. Garcia
Benjamin A. Garcia Washington University in St. Louis

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