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Matthew D. Hirschey

Matthew D. Hirschey

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
19161
World Ranking
15906
National Ranking
6608

Overview

Matthew D. Hirschey is affiliated with Duke University in the United States and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their research spans several subfields, including Molecular Biology, Cancer Research, Organic Chemistry, Geriatrics and Gerontology, and Physiology.

Their recent published papers include:

  • NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism, 2020, Nature Metabolism
  • Discovering the landscape of protein modifications, 2021, Molecular Cell
  • NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease, 2023, Journal of Biological Chemistry
  • Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans, 2021, Redox Biology
  • Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone, 2020, Toxicology

Frequent co-authors collaborating with Matthew D. Hirschey include:

  • Olga Ilkayeva, with 11 joint publications
  • Paul A. Grimsrud, with 9 joint publications
  • Pol Castellano-Escuder, with 8 joint publications
  • Dhaval P. Bhatt, with 7 joint publications
  • Kristin A. Anderson, with 6 joint publications

The scientist has published pieces primarily in the following venues:

  • Zenodo (CERN European Organization for Nuclear Research), 13 publications
  • bioRxiv (Cold Spring Harbor Laboratory), 11 publications
  • Journal of Biological Chemistry, 3 publications
  • Nature Metabolism, 2 publications
  • Nature Communications, 2 publications

The main topics of Matthew D. Hirschey's research include:

  • Sirtuins and Resveratrol in Medicine
  • Cancer, Lipids, and Metabolism
  • Chemistry and Stereochemistry Studies
  • Genetics, Aging, and Longevity in Model Organisms
  • Peroxisome Proliferator-Activated Receptors
  • Lipoproteins and Cardiovascular Health
  • Cancer, Hypoxia, and Metabolism

Best Publications

  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

    Matthew D. Hirschey;Tadahiro Shimazu;Tadahiro Shimazu;Eric Goetzman;Enxuan Jing

  • Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

    Tadahiro Shimazu;Matthew D. Hirschey;John Newman;Wenjuan He

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

    Xiaolei Qiu;Katharine Brown;Matthew D. Hirschey;Eric Verdin

  • SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

    Matthew D. Hirschey;Tadahiro Shimazu;Enxuan Jing;Carrie A. Grueter

  • Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

    Minjia Tan;Chao Peng;Kristin A. Anderson;Peter Chhoy

  • Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.

    Eric Verdin;Matthew D. Hirschey;Lydia W.S. Finley;Marcia C. Haigis

  • Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

    Enxuan Jing;Brice Emanuelli;Matthew D. Hirschey;Jeremie Boucher

  • SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

    Tadahiro Shimazu;Matthew D. Hirschey;Lan Hua;Kristin E. Dittenhafer-Reed

  • Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

    Matthew D. Hirschey;Yingming Zhao

  • Designing a broad-spectrum integrative approach for cancer prevention and treatment

    Keith I. Block;Charlotte Gyllenhaal;Leroy Lowe;Amedeo Amedei

  • Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.

    Heather J. Weir;Pallas Yao;Frank K. Huynh;Caroline C. Escoubas

  • Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.

    Gregory R. Wagner;Matthew D. Hirschey

  • Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

    Eoin McDonnell;Eoin McDonnell;Scott B. Crown;Douglas B. Fox;Betül Kitir

  • The sirtuins, oxidative stress and aging: an emerging link.

    Philip I. Merksamer;Yufei Liu;Wenjuan He;Matthew D. Hirschey

  • SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

    Kristin A. Anderson;Frank K. Huynh;Kelsey Fisher-Wellman;J. Darren Stuart

  • Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Daniel T. Shaughnessy;Kimberly McAllister;Leroy Worth;Astrid C. Haugen

  • Mitochondrial protein acetylation regulates metabolism

    Kristin A. Anderson;Matthew D. Hirschey

  • A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation

    Gregory R. Wagner;Dhaval P. Bhatt;Thomas M. O’Connell;J. Will Thompson

  • SIRT3 regulates progression and development of diseases of aging.

    Eoin McDonnell;Brett S. Peterson;Howard M. Bomze;Matthew D. Hirschey;Matthew D. Hirschey

Frequent Co-Authors

Olga Ilkayeva
Olga Ilkayeva Duke University
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Jason W. Locasale
Jason W. Locasale Duke University
Joel N. Meyer
Joel N. Meyer Duke University
Christopher B. Newgard
Christopher B. Newgard Duke University
Robert V. Farese
Robert V. Farese Harvard University
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
David B. Lombard
David B. Lombard University of Michigan–Ann Arbor
Yingming Zhao
Yingming Zhao University of Chicago
Dennis R. Petersen
Dennis R. Petersen University of Colorado Anschutz Medical Campus

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