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Matthew D. Hirschey

Matthew D. Hirschey

Duke University
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
19161
World Ranking
15906
National Ranking
6608

Matthew D. Hirschey publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Matthew D. Hirschey sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 107 publications — 7th percentile

7% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Matthew D. Hirschey D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Matthew D. Hirschey sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 53 D-Index — 19th percentile

19% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Matthew D. Hirschey is affiliated with Duke University in the United States and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their research spans several subfields, including Molecular Biology, Cancer Research, Organic Chemistry, Geriatrics and Gerontology, and Physiology.

Their recent published papers include:

  • NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism, 2020, Nature Metabolism
  • Discovering the landscape of protein modifications, 2021, Molecular Cell
  • NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease, 2023, Journal of Biological Chemistry
  • Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans, 2021, Redox Biology
  • Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone, 2020, Toxicology

Frequent co-authors collaborating with Matthew D. Hirschey include:

  • Olga Ilkayeva, with 11 joint publications
  • Paul A. Grimsrud, with 9 joint publications
  • Pol Castellano-Escuder, with 8 joint publications
  • Dhaval P. Bhatt, with 7 joint publications
  • Kristin A. Anderson, with 6 joint publications

The scientist has published pieces primarily in the following venues:

  • Zenodo (CERN European Organization for Nuclear Research), 13 publications
  • bioRxiv (Cold Spring Harbor Laboratory), 11 publications
  • Journal of Biological Chemistry, 3 publications
  • Nature Metabolism, 2 publications
  • Nature Communications, 2 publications

The main topics of Matthew D. Hirschey's research include:

  • Sirtuins and Resveratrol in Medicine
  • Cancer, Lipids, and Metabolism
  • Chemistry and Stereochemistry Studies
  • Genetics, Aging, and Longevity in Model Organisms
  • Peroxisome Proliferator-Activated Receptors
  • Lipoproteins and Cardiovascular Health
  • Cancer, Hypoxia, and Metabolism

Best Publications

  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

    Matthew D. Hirschey;Tadahiro Shimazu;Tadahiro Shimazu;Eric Goetzman;Enxuan Jing

  • Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

    Tadahiro Shimazu;Matthew D. Hirschey;John Newman;Wenjuan He

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

    Xiaolei Qiu;Katharine Brown;Matthew D. Hirschey;Eric Verdin

  • SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

    Matthew D. Hirschey;Tadahiro Shimazu;Enxuan Jing;Carrie A. Grueter

  • Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

    Minjia Tan;Chao Peng;Kristin A. Anderson;Peter Chhoy

  • Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.

    Eric Verdin;Matthew D. Hirschey;Lydia W.S. Finley;Marcia C. Haigis

  • Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

    Enxuan Jing;Brice Emanuelli;Matthew D. Hirschey;Jeremie Boucher

  • SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

    Tadahiro Shimazu;Matthew D. Hirschey;Lan Hua;Kristin E. Dittenhafer-Reed

  • Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

    Matthew D. Hirschey;Yingming Zhao

  • Designing a broad-spectrum integrative approach for cancer prevention and treatment

    Keith I. Block;Charlotte Gyllenhaal;Leroy Lowe;Amedeo Amedei

  • Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.

    Heather J. Weir;Pallas Yao;Frank K. Huynh;Caroline C. Escoubas

  • Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.

    Gregory R. Wagner;Matthew D. Hirschey

  • Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

    Eoin McDonnell;Eoin McDonnell;Scott B. Crown;Douglas B. Fox;Betül Kitir

  • The sirtuins, oxidative stress and aging: an emerging link.

    Philip I. Merksamer;Yufei Liu;Wenjuan He;Matthew D. Hirschey

  • SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

    Kristin A. Anderson;Frank K. Huynh;Kelsey Fisher-Wellman;J. Darren Stuart

  • Mitochondria, energetics, epigenetics, and cellular responses to stress.

    Daniel T. Shaughnessy;Kimberly McAllister;Leroy Worth;Astrid C. Haugen

  • Mitochondrial protein acetylation regulates metabolism

    Kristin A. Anderson;Matthew D. Hirschey

  • A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation

    Gregory R. Wagner;Dhaval P. Bhatt;Thomas M. O’Connell;J. Will Thompson

  • SIRT3 regulates progression and development of diseases of aging.

    Eoin McDonnell;Brett S. Peterson;Howard M. Bomze;Matthew D. Hirschey;Matthew D. Hirschey

Frequent Co-Authors

Olga Ilkayeva
Olga Ilkayeva Duke University
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Jason W. Locasale
Jason W. Locasale Duke University
Joel N. Meyer
Joel N. Meyer Duke University
Christopher B. Newgard
Christopher B. Newgard Duke University
Robert V. Farese
Robert V. Farese Harvard University
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
David B. Lombard
David B. Lombard University of Michigan–Ann Arbor
Yingming Zhao
Yingming Zhao University of Chicago
Dennis R. Petersen
Dennis R. Petersen University of Colorado Anschutz Medical Campus

External Links

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Best Scientists Citing Matthew D. Hirschey

Eric Verdin

Eric Verdin

Buck Institute for Research on Aging

Publications: 57

John M. Denu

John M. Denu

University of Wisconsin–Madison

Publications: 41

David Gius

David Gius

Northwestern University

Publications: 36

Johan Auwerx

Johan Auwerx

École Polytechnique Fédérale de Lausanne

Publications: 34

David A. Sinclair

David A. Sinclair

Harvard University

Publications: 34

Yingming Zhao

Yingming Zhao

University of Chicago

Publications: 33

Jason W. Locasale

Jason W. Locasale

Duke University

Publications: 33

Michael N. Sack

Michael N. Sack

National Institutes of Health

Publications: 31

David B. Lombard

David B. Lombard

University of Michigan–Ann Arbor

Publications: 31

Marcia C. Haigis

Marcia C. Haigis

Harvard University

Publications: 30

Leonard Guarente

Leonard Guarente

MIT

Publications: 28

Kun-Liang Guan

Kun-Liang Guan

Westlake University

Publications: 25

Hening Lin

Hening Lin

Howard Hughes Medical Institute

Publications: 24

Clemens Steegborn

Clemens Steegborn

University of Bayreuth

Publications: 24

Yue Xiong

Yue Xiong

University of North Carolina at Chapel Hill

Publications: 22

Raul Mostoslavsky

Raul Mostoslavsky

Harvard University

Publications: 20

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